Assessment of the effects of the nitroimidazo-oxazine PA-824 on renal function in healthy subjects

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 9, 2009, Pages 3726-3733

  Ginsberg, Ann M ^a   Laurenzi, Martino W ^a   Rouse, Doris J ^b   Whitney, Karl D ^b   Spigelman, Mel K ^a  

^a GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT   (United States)

^b RTI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; 6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; CREATININE; DIPHENHYDRAMINE; HYDROXYZINE; IOHEXOL; PLACEBO; PREDNISONE; URIC ACID;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CREATININE URINE LEVEL; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG ERUPTION; DRUG MECHANISM; DRUG WITHDRAWAL; FEMALE; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; HEADACHE; HUMAN; HUMAN EXPERIMENT; HYPOALBUMINEMIA; IRON DEFICIENCY; KIDNEY FUNCTION; KIDNEY PLASMA FLOW; MALE; MAXIMUM PLASMA CONCENTRATION; NEPHROSIS; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEINURIA; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION; UREA BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ADULT; ANTITUBERCULAR AGENTS; BLOOD UREA NITROGEN; CREATININE; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; NITROIMIDAZOLES; RENAL PLASMA FLOW, EFFECTIVE; YOUNG ADULT;

EID: 70349136685     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00112-09     Document Type: Article

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