Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 19, 2007, Pages 5316-5320

  Cheng, Pi ^a,c   Ma, Yun bao ^a,b   Yao, Shu ying ^a,c   Zhang, Quan ^a,c   Wang, En jun ^a,c   Yan, Meng hong ^a,c   Zhang, Xue mei ^a,b   Zhang, Feng xue ^d   Chen, Ji jun ^a,b  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Anti HBV activity; Hypserpa nitida; Hypserpanine A; Hypserpanine B; Menispermaceae; Structure elucidation

Indexed keywords

ACUTUMIDINE; ACUTUMINE; ALKALOID; DAURICUMIDINE; DECHLOROACUTUMINE; GLAZIOVINE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS E ANTIGEN; HYPSERPANINE; LAURIFOLINE; MAGNOFLORINE; PHENOLBETAIN; PRONUCIFERIN; S RETICULINE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; HEPATITIS B; HYPSERPA NITIDA; IC 50; IN VITRO STUDY; MEDICINAL PLANT; MENISPERMACEAE; NONHUMAN; SPECTROSCOPY; VIRUS STRAIN;

ALKALOIDS; ANTIVIRAL AGENTS; CELL LINE; CHROMATOGRAPHY, ION EXCHANGE; DIETHYLAMINES; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MENISPERMACEAE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPIRO COMPOUNDS;

HEPATITIS B VIRUS; HYPSERPA NITIDA; MENISPERMACEAE;

EID: 34548568874     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.027     Document Type: Article

References (23)

1. Kane M. Vaccine 13 (1995) S47
2. Shin M.S., Kang E.H., and Lee Y.I. Antiviral Res. 67 (2005) 163
3. Zhou Z., Zhang Y., Ding X., Chen S., Yang J., Wang X., Jia G., Chen H., Bo X., and Wang S. Antiviral Res. 74 (2007) 59
4. Ding P., Liao Z., Huang H., Zhou P., and Chen D. Bioorg. Med. Chem. Lett. 16 (2006) 1231
5. Wu Z., Zhou T., and Xiao P. XinhuaBencaoGangyao Vol. 1 (1988), Shanghai Scientific and Technical Publisher, Shanghai 172
6. Jiang Z., Zhang X., Zhang F., Liu N., Zhao F., Zhou J., and Chen J. Planta Med. 72 (2006) 951
7. 2O, 50:50) and Toyopearl HW-40 C column (MeOH) repeatedly to yield compounds 11 (14 mg), 12 (385 mg) and 13 (48 mg).
8. Göber B., Pfeifer S., Pankow K., and Kraft R. Pharmazie 34 (1979) 830
9. Sugimoto Y., Babiker H.A.A., Saisho T., Furumoto T., Inanaga S., and Kato M. J. Org. Chem. 66 (2001) 3299
10. Tomita M., Okamoto Y., Kikuchi T., Osaki K., Nishikawa M., Kamiya K., Sasaki Y., Matoba K., and Goto K. Chem. Pharm. Bull. 19 (1971) 770
11. Sugimoto Y., Inanaga S., Kato M., Shimizu T., Hakoshima T., and Isogai A. Phytochemistry 49 (1998) 1293
12. Honda T., and Shigehisa H. Org. Lett. 8 (2006) 657
13. Stuart K.L., and Cava M.P. Chem. Rev. 68 (1968) 321
14. Chen J., Chang Y., Teng C., and Chen I. Planta Med. 66 (2000) 251
15. Brochmann-Hanssen E., and Nielsen B. Tetrahedron Lett. 18 (1965) 1271
16. Barbosa-Filho J.M., Da-Cunha E.V.L., Cornélio M.L., Dias C.D.S., and Gray A.I. Phytochemistry 44 (1997) 959
17. Stermitz F.R., Castedo L., and Dominguez D. J. Nat. Prod. 43 (1980) 140
18. Domi{dotless}́nguez X.A., Benavides L., and Butruille D. Phtochemistry 13 (1974) 680
19. Marsaioli A.J., Reis F.D.A.M., Magalhães A.F., Rúveda E.A., and Kuck A.M. Phytochemistry 18 (1979) 165
20. 13C NMR data, see Table 1.
21. Okamoto Y., Yuge E., Nagai Y., Katsuta R., Kishimoto A., Kobayashi Y., Kikuchi T., and Tomita M. Tetrahedron Lett. 24 (1969) 1933
22. 13C NMR data, see Table 2.
23. Ringdahl B., Chan R.P.K., Craig C., Cava M.P., and Shamma M. J. Nat. Prod. 44 (1981) 80