The influence of cytosine methylation on the chemoselectivity of benzo[a]pyrene diol epoxide-oligonucleotide adducts determined using nanoLC/MS/MS

Journal of Mass Spectrometry

Volumn 44, Issue 8, 2009, Pages 1241-1248

  Glick, James ^a   Xiong, Wennan ^a   Lin, Yiqing ^a   Noronha, Anne M ^b   Wilds, Christopher J ^b   Vouros, Paul ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b Civil and Environmental Engineering   (Canada)

Author keywords

BPDE; DNA adducts; LC MS; Methylation; Monolithic column; Oligonucleotides

Indexed keywords

ADDUCT FORMATION; BENZO [A] PYRENE; BPDE; CHEMO-SELECTIVITY; CHEMOSELECTIVE; CHROMATOGRAPHIC RESOLUTIONS; COMPLEMENTARY STRAND; DINUCLEOTIDES; DNA ADDUCTS; HOT SPOT; HUMAN LUNG; IN-VITRO; LC-MS; MINIMAL SAMPLE; MONOLITHIC COLUMN; MUTATION SITES; NANOCOLUMN; NUCLEOBASES; P53 GENE; PERMETHYLATION; POSITIONAL ISOMERS; RELATIVE RATIOS; TUMOR SUPPRESSOR GENES;

ALKYLATION; BINDING ENERGY; BIOLOGICAL ORGANS; DNA; GENES; ISOMERS; METHYLATION; NUCLEIC ACIDS; OLIGONUCLEOTIDES; SYNTHESIS (CHEMICAL);

BINDING SITES;

BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; CPG DINUCLEOTIDE; CPG OLIGODEOXYNUCLEOTIDE; CYTOSINE; DIHYDROXYBENZO[A]PYRENE OXIDE; DINUCLEOTIDE; DNA; NUCLEIC ACID BASE; NUCLEOBASE G5; OLIGOMER; OLIGONUCLEOTIDE; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARCINOGENESIS; CHEMOSELECTIVITY; CHEMOSENSITIVITY; CODON; CONTROLLED STUDY; CYCLOADDITION; GENE MUTATION; GENE SEQUENCE; HUMAN; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; OLIGOMERIZATION; ONLINE ANALYSIS; PRIORITY JOURNAL; PROTEIN METHYLATION; SYNTHESIS;

5-METHYLCYTOSINE; 7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANALYTIC SAMPLE PREPARATION METHODS; BENZO(A)PYRENE; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CODON; CYTOSINE; DNA; DNA ADDUCTS; DNA METHYLATION; GENES, P53; GUANINE; HUMANS; MICROCHEMISTRY; MUTAGENS; OLIGONUCLEOTIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 70349128590     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1605     Document Type: Article

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