Diagnostic importance of overexpression of Bmi-1 mRNA in early breast cancers

International Journal of Oncology

Volumn 35, Issue 3, 2009, Pages 511-515

  Saeki, Masachika ^a   Kobayashi, Daisuke ^a   Tsuji, Naoki ^a   Kuribayashi, Kageaki ^a   Watanabe, Naoki ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bmi 1; Breast cancers; Diagnosis; mRNA expression; TaqMan RT PCR

Indexed keywords

BMI1 PROTEIN;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; DIAGNOSTIC VALUE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; NORMAL VALUE; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; SENSITIVITY AND SPECIFICITY;

BREAST NEOPLASMS; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ROC CURVE; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 70349126346     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000362     Document Type: Article

References (13)

1. Alkema MJ, Wiegant J, Raap AK, Berns A and van Lohuizen M: Characterization and chromosomal localization of the human proto-oncogene BMI-1. Hum Mol Genet 2: 1597-1603, 1993.
2. Van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H and Berns A: Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65: 737-752, 1991.
3. Haupt Y, Alexander WS, Barri G, Klinken SP and Adams JM: Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 65: 753-763, 1991.
4. Datta S, Hoenerhoff MJ, Bommi P, et al: Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways. Cancer Res 67: 10286-10295, 2007.
5. Dimri GP, Martinez JL, Jacobs JJ, et al: The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 62: 4736-4745, 2002.
6. Liu L, Andrews LG and Tollefsbol TO: Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death. Oncogene 25: 4370-4375, 2006.
7. Silva J, Garcia JM, Peña C, et al: Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas. Clin Cancer Res 12: 6929-6936, 2006.
8. Choi YJ, Choi YL, Cho EY, et al: Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients. Breast Cancer Res Treat 113: 83-93, 2009.
9. Koshida S, Kobayashi D, Moriai R, Tsuji N and Watanabe N: Specific overexpression of OLFM4(GW112/HGC-1) mRNA in colon, breast and lung cancer tissues detected using quantitative analysis. Cancer Sci 98: 315-320, 2007.
10. Yajima T, Yagihashi A, Kameshima H, et al: Quantitative reverse transcription-PCR assay of the RNA component of human telomerase using the TaqMan fluorogenic detection system. Clin Chem 44: 2441-2445, 1998.
11. Amachika T, Kobayashi D, Moriai R, Tsuji N and Watanabe N: Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. Lung Cancer 56: 337-340, 2007.
12. Liu W, Liu Y, Zhu J, Wright E, Ding I and Rodgers GP: Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma. Clin Cancer Res 14: 1041-1049, 2008.
13. Silva J, García V, García JM, et al: Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients. Breast Cancer Res 9: R55, 2007.