Role of cyclic AMP-dependent kinase response element-binding protein in recombinant adeno-associated virus-mediated transduction of heart muscle cells

Human Gene Therapy

Volumn 20, Issue 9, 2009, Pages 1005-1012

  Dean, Jarrod ^a   Plante, Jeremy ^a   Huggins, Gordon S ^a   Snyder, Richard O ^b   Aikawa, Ryuichi ^a,c  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; ISOPRENALINE; PARVOVIRUS VECTOR; SERINE; SMALL INTERFERING RNA;

ADENOVIRUS; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; GENE SILENCING; GENE TARGETING; GENE TRANSFER; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HEART MUSCLE CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMID; PROTEIN PHOSPHORYLATION; VIRUS GENOME;

ANIMALS; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPENDOVIRUS; GENETIC VECTORS; HUMANS; IMMUNOBLOTTING; ISOPROTERENOL; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PHOSPHORYLATION; RATS; RECOMBINATION, GENETIC; RNA, SMALL INTERFERING; TRANSDUCTION, GENETIC;

ADENO-ASSOCIATED VIRUS; MUS; PRIMATES;

EID: 70349125494     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2009.054     Document Type: Article

References (43)

1. Aikawa, R., Huggins, G.S., and Snyder, R.O. (2002). Cardiomyocyte- specific gene expression following recombinant adeno-associated viral vector transduction. J. Biol. Chem. 277, 18979-18985.
2. Asfour, B., Baba, H.A., Scheld, H.H., Hruban, R.H., Hammel, D., and Byrne, B.J. (2002). Uniform long-term gene expression using adenoassociated virus (AAV) by ex vivo recirculation in rat-cardiac isografts. Thorac. Cardiovasc. Surg. 50, 347-350.
3. Braunstein, M., Rose, A.B., Holmes, S.G., Allis, C.D., and Broach, J.R. (1993). Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7, 592-604.
4. Chen, H., Lin, R.J., Xie, W., Wilpitz, D., and Evans, R.M. (1999). Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98, 675-686.
5. Chen, W.Y., and Townes, T.M. (2000). Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. Proc. Natl. Acad. Sci. U.S.A. 97, 377-382.
6. Chen, W.Y., Bailey, E.C., McCune, S.L., Dong, J.Y., and Townes, T.M. (1997). Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc. Natl. Acad. Sci. U.S.A. 94, 5798-5803.
7. Cole, S.W., Jamieson, B.D., and Zack, J.A. (1999). cAMP upregulates cell surface expression of lymphocyte CXCR4: implications for chemotaxis and HIV-1 infection. J. Immunol. 162, 1392-1400.
8. DiNardo, D.N., Butcher, D.T., Robinson, D.P., Archer, T.K., and Rodenhiser, D.I. (2001). Functional analysis of CpG methylation in the BRCA1 promoter region. Oncogene 20, 5331-5340.
9. Di Pasquale, G., and Chiorini, J.A. (2003). PKA=PrKX activity is a modulator of AAV=adenovirus interaction. EMBO J. 22, 1716-1724.
10. Duan, D., Yan, Z., Yue, Y., and Engelhardt, J.F. (1999). Structural analysis of adeno-associated virus transduction circular intermediates. Virology 261, 8-14.
11. Fentzke, R.C., Korcarz, C.E., Lang, R.M., Lin, H., and Leiden, J.M. (1998). Dilated cardiomyopathy in transgenic mice expressing a dominant negative CREB transcription factor in the heart. J. Clin. Invest. 101, 2415-2426.
12. Fisher, K.J., Jooss, K., Alston, J., Yang, Y., Haecker, S.E., High, K., Pathak, R., Raper, S.E., and Wilson, J.M. (1997). Recombinant adenoassociated virus for muscle directed gene therapy. Nat. Med. 3, 306-312.
13. Flotte, T.R., Brantly, M.L., Spencer, L.T., Byrne, B.J., Spencer, C.T., Baker, D.J., and Humphries, M. (2004). Phase I trial of intramuscular injection of a recombinant adeno-associated virus a1-antitrypsin (rAAV2-CB-hAAT) gene vector to AATdeficient adults. Hum. Gene Ther. 15, 93-128.
14. Gilchrist, C.A., Orten, D.J., and Hinrichs, S.H. (1996). Evidence for the role of cyclic AMP-responsive elements in human virus replication and disease. J. Biomed. Sci. 3, 293-306.
15. Gonzalez, G.A., and Montminy, M.R. (1989). Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59, 675-680.
16. Goodman, R.H., and Smolik, S. (2000). CBP=p300 in cell growth, transformation, and development. Genes Dev. 14, 1553-1577.
17. Goyenvalle, A., Vulin, A., Fougerousse, F., Leturcq, F., Kaplan, J.C., Garcia, L., and Danos, O. (2004). Rescue of dystrophic muscle through U7 snRNA-mediated exon skipping. Science 306, 1796-1799.
18. Gupta, M., Zak, R., Libermann, T.A., and Gupta, M.P. (1998) Tissue restricted expression of the cardiac a-myosin heavy chain gene is controlled by a downstream repressor element containing a palindrome of two ETS-binding sites. Mol. Cell. Biol. 18, 7243-7258.
19. Gusterson, R.J., Jazrawi, E., Adcock, I.M., and Latchman, D.S. (2002). The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. J. Biol.Chem. 278, 6838-6847.
20. Hai, T., and Curran, T. (1991). Cross-family dimerization of transcription factors Fos=Jun and ATF=CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. U.S.A. 88, 3720-3724.
21. Hoeffler, J.P.,Meyer, T.E., Yun, Y., Jameson, J.L., and Habener, J.F. (1988). Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242, 1430-1433.
22. Iwakura, A., Dean, J., Hamada, H., Eaton, E., Qin, G., Losordo, D.W., and Aikawa, R. (2005). Use of recombinant adeno-associated viral vectors as a tool for labeling bone marrow cells. . Mol. Cell. Cardiol. 38, 799-802.
23. Kamiya, K., Sakakibara, K., Ryer, E.J., Hom, R.P., Leof, E.B., Kent, K.C., and Liu, B. (2007). Phosphorylation of the cyclic AMP response element binding protein mediates transforming growth factor b-induced downregulation of cyclin A in vascular smooth muscle cells. Mol.Cell. Biol. 27, 3489-3498.
24. Lee, K.A., Hai, T.Y., Sivaraman, L., Thimmappaya, B., Hurst, H.C., Jones, N.C., and Green, M.R. (1987). A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters. Proc. Natl. Acad. Sci. U.S.A. 84, 8355-8359.
25. Li, Q., Xiao, H., and Isobe, K. (2002). Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice. J. Gerontol. A Biol. Sci. Med. Sci. 57, B93-B98.
26. Lundblad, J.R., Kwok, R.P., Laurance, M.E., Harter, M.L., and Goodman, R.H. (1995). Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374, 85-88.
27. Manno, C.S., Pierce, G.F., Arruda, V.R., Glader, B., Ragni, M., Rasko, J.E., Ozelo, M.C., Hoots, K., Blatt, P., Konkle, B., Dake, M., Kaye, R., Razavi, M., Zajko, A., Zehnder, J., Rustagi, P.K., Nakai, H., Chew, A., Leonard, D., Wright, J.F., Lessard, R.R., Sommer, J.M., Tigges, M., Sabatino, D., Luk, A., Jiang, H., Mingozzi, F., Couto, L., Ertl, H.C., High, K.A., and Kay, M.A. (2006). Successful transduction of liver in hemophilia by AAVFactor IX and limitations imposed by the host immune response. Nat. Med. 12, 342-347.
28. Mayr, B., and Montminy, M. (2001). Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell. Biol. 2, 599-609.
29. Molkentin, J.D., Jobe, S.M., and Markham, B.E. (1996). a-Myosin heavy chain gene regulation: Delineation and characterization of the cardiac muscle-specific enhancer and muscle-specific promoter. J. Mol. Cell. Cardiol. 28, 1211-1225.
30. Okada, T., Uchibori, R., Iwata-Okada, M., Takahashi, M., Nomoto, T., Nonaka-Sarukawa, M., Ito, T., Liu, Y., Mizukami, H., Kume, A., Kobayashi, E., and Ozawa, K. (2006). A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells. Mol. Ther. 13, 738-746.
31. Palomeque, J., Chemaly, E.R., Colosi, P., Wellman, J.A., Zhou, S., Del Monte, F., and Hajjar, R.J. (2007). Efficiency of eight different AAV serotypes in transducing rat myocardium in vivo. Gene Ther. 14, 989-997.
32. Penaud-Budloo, M., Le Guiner, C., Nowrouzi, A., Toromanoff, A., Chérel, Y., Chenuaud, P., Schmidt, M., Von Kalle, C., Rolling, F., Moullier, P., and Snyder, R.O. (2008). Adenoassociated viral vector genomes persist as episomal chromatin in primate muscle. J. Virol. 82, 7875-7885.
33. Roth, S.Y., Denu, J.M., and Allis, C.D. (2001). Histone acetyltransferases. Annu. Rev. Biochem. 70, 81-120.
34. Sands, W.A., and Palmer, T.M. (2008). Regulating gene transcription in response to cyclicAMP elevation.Cell. Signal. 20, 460-466.
35. Schnepp, B.C., Jensen, R.L., Chen, C.L., Johnson, P.R., and Clark, K.R. (2005). Characterization of adeno-associated virus genomes isolated from human tissues. J. Virol. 79, 14793-14803.
36. Seisenberger, G., Ried, M.U., Endress, T., Büning, H., Hallek, M., and Bräuchle, C. (2001). Real-time single-molecule imaging of the infection pathway of an adeno-associated virus. Science 294, 1929-1932. (Pubitemid 33101590)
37. Snyder, R.O., Spratt, S.K., Lagarde, C., Bohl, D., Kaspar, B., Sloan, B., Cohen, L.K., and Danos, O. (1997). Efficient and stable adenoassociated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice. Hum. Gene Ther. 8, 1891-1900.
38. Somers, J.P., Deloia, J.A., and Zeleznik, A.J. (1999). Adenovirusdirected expression of a nonphosphorylatable mutant of CREB (cAMP response element-binding protein) adversely affects the survival, but not the differentiation, of rat granulosa cells. Mol. Endocrinol. 13, 1364-1372.
39. Wang, L., Dobrzynski, E., Schlachterman, A., Cao, O., and Herzog, R.W. (2005). Systemic protein delivery by musclegene transfer is limited by a local immune response. Blood 105, 4226-4234.
40. Wheeler, D.G., and Cooper, E. (2001). Depolarization strongly induces human cytomegalovirus major immediate-early promoter=enhancer activity in neurons. J. Biol. Chem. 276, 31978-31985.
41. Xiao, X., Li, J., and Samulski, R.J. (1996). Efficient long-term gene ransfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J. Virol. 70, 8098-8108.
42. Xiao, X., Li, J., Tsao, Y.P., Dressman, D., Hoffman, E.P., and Watchko, J.F. (2000). Full functional rescue of a complete muscle (TA) in dystrophic hamsters by adeno-associated virus vector-directed gene therapy. J. Virol. 74, 1436-1442.
43. Yamamoto, K.K., Gonzalez, G.A., Biggs, W.H., III, and Montminy, M.R. (1988). Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature 334, 494-498.