Open-label pilot trial of levetiracetam for cramps and spasticity in patients with motor neuron disease

Amyotrophic Lateral Sclerosis

Volumn 10, Issue 4, 2009, Pages 210-215

  Bedlack, Richard S ^a   Pastula, Daniel M ^a   Hawes, Jodi ^a   Heydt, Debra ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cramps; Levetiracetam; Motor neuron disease; Spasticity

Indexed keywords

ALPHA TOCOPHEROL; BACLOFEN; CLONAZEPAM; ETIRACETAM; GABAPENTIN; QUININE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; MALE; MOTOR NEURON DISEASE; MUSCLE CRAMP; PILOT STUDY; PRIORITY JOURNAL; QUALITY OF LIFE; SPASTICITY; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADULT; AGED; ANTICONVULSANTS; DISEASE PROGRESSION; HUMANS; MIDDLE AGED; MOTOR NEURON DISEASE; MUSCLE CRAMP; MUSCLE SPASTICITY; PILOT PROJECTS; PIRACETAM; PLACEBOS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 70249150025     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.1080/17482960802430773     Document Type: Article

References (24)

1. McGee S. Muscle cramps. Arch Intern Med. 1990;150: 511-8.
2. Norris FH, Gasteiger EL, Chatfielf PD. An electromyographic study of induced and spontaneous cramps. Electroencephalogr Clin Neurophysiol. 1957;9:139-47.
3. Riley J, Antony S. Leg cramps: Differential diagnosis and management. American Family Physician. 1995;52:1794-8.
4. Miller R, Moore D, Young L, Armon C, Barohn RJ, Bromberg MB, et al. Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology. 1996;47:1383-8.
5. Hawker K, Frohman E, Racke M. Levetiracetam for phasic spasticity in multiple sclerosis. Archives of Neurology. 2003;60:1772-4.
6. Ivanhoe C, Reistetter T. Spasticity: The misunderstood part of the upper motor neuron syndrome. Am J Phys Med Rhabil. 2004;83(Suppl):S3-9.
7. Raynor E, Shefner J. Recurrent inhibition is decreased in patients with amyotrophic lateral sclerosis. Neurology. 1994;44:2148-53.
8. Forshew D, Bromber M A. survey of clinicians' practice in the symptomatic treatment of ALS. Amyotroph Lateral Scler Other Motor Neuron Disord. 2003;4:258-63.
9. Norris F, Sachais B, Carey M. Trial of baclofen in amyotrophic lateral sclerosis. Archives of Neurology. 1979;36: 715-6.
10. De Carvalho M. Gabapentin for the treatment of spasticity in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis. 2001;2:47-8.
11. Miller R, Moore D, Gelinas D. Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology. 2001;56:843-8.
12. Marquardt G, Lorenz R. Intrathecal baclofen for intractable spasticity in amyotrophic lateral sclerosis. Journal of Neurology. 1999;246:619-20.
13. Lynch B, Lambeng N, Nocka K, Kensel P, Bajjalieh M, Matagne A, et al. The synaptic vesicle protein SV2A is the binding site for the drug levetiracetam. Proc Natl Acad Sci USA. 2004;101:9861-6.
14. 2 + current in pyramidal neurons of rat hippocampal slices. Neurosci Lett. 2001;306:5-8.
15. Lukyanetz EA, Shkryl VM, Kostyuk PG. Selective blockade of N-type calcium channels by levetiracetam. Epilepsia. 2002;43:9-18.
16. Rigo JM, Hans G, Nguyen L, Rocher V, Belachew S, Malgrange B, et al. Levetiracetam: Novel modulation of ionotropic inhibitory receptors (abstract). Epilepsia. 2000;41(Suppl 7):35.
17. Deleu D. Levetiracetam in the treatment of idiopathic hemifacial spasm. Neurology. 2004;62:2134-5.
18. Ruegg S, Stack A, Fuhr P. Levetiracetam improves paroxysmal symptoms in a patient with stiff-person syndrome. Neurology. 2004;62:338.
19. Bedlack RS, Bellanich M, Bromberg M, Cudkowicz M. Levetiracetam treatment for spasticity in motor neuron diseases: A case series. Amyotroph Lateral Scler Other Motor Neuron Disord. 2006;7(Suppl 1):111.
20. World Federation of Neurology Research Group on Neuromuscular Diseases 1994. El Escorial World Federation of Neurology Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis. Journal of Neurological Science. 1994;124(Suppl): 96-107.
21. Lars D, Berg G, Hammar M, Mats H, Lasse L. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gyenecol. 1995;173:175-80.
22. Man-Son-Hing M, Wells G. Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people. Br Med J. 1995;310:13-7.
23. Stambler N, Charatran M, Cedarbaum J. Prognostic indicators of survival in ALS. Neurology. 1998;60:66-72.
24. Karsarkis E. ALSFRS-R Validity on the Phone. Presented at the 15th Annual International Symposium on ALS/MND, Philadelphia 2004.