메뉴 건너뛰기




Volumn 5, Issue 9, 2009, Pages 1135-1140

Epinastine: Topical ophthalmic second generation antihistamine without significant systemic side effects

Author keywords

Allergic conjunctivitis; Epinastine; Ocular allergy

Indexed keywords

AZELASTINE; EPINASTINE; KETOTIFEN; OLOPATADINE;

EID: 70249108858     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425250903117284     Document Type: Review
Times cited : (11)

References (48)
  • 1
    • 0034544915 scopus 로고    scopus 로고
    • Allergic and immunologic disorders of the eye. Part II: Ocular allergy
    • DOI 10.1067/mai.2000.111238
    • Bielory L. Allergic and immunologic disorders of the eye: part II. Ocular allergy. J Allergy Clin Immunol 2000;106(6):1019-1032 (Pubitemid 32006253)
    • (2000) Journal of Allergy and Clinical Immunology , vol.106 , Issue.6 , pp. 1019-1032
    • Bielory, L.1
  • 5
    • 0032410426 scopus 로고    scopus 로고
    • Histamine - A major role in allergy?
    • Bachert C. Histamine - A major role in allergy? Clin Exp Allergy 1998;28(Suppl 6):15-19
    • (1998) Clin Exp Allergy , vol.28 , Issue.SUPPL. 6 , pp. 15-19
    • Bachert, C.1
  • 7
  • 8
    • 0031158329 scopus 로고    scopus 로고
    • The prevalence and medical and economic impact of allergic rhinitis in the United States
    • Meltzer EO. The prevalence and medical and economic impact of allergic rhinitis in the United States. J Allergy Clin Immunol 1997;99:S805-28
    • (1997) J Allergy Clin Immunol , vol.99
    • Meltzer, E.O.1
  • 9
    • 0027236762 scopus 로고
    • Effects of allergy season on mood and cognitive function
    • Marshall PS, Colon EA. Effects of allergy season on mood and cognitive function. Ann Allergy 1993;71:251-258
    • (1993) Ann Allergy , vol.71 , pp. 251-258
    • Marshall, P.S.1    Colon, E.A.2
  • 11
    • 0036016092 scopus 로고    scopus 로고
    • Next generation antihistamines: Therapeutic rationale, accomplishments, and advances
    • Oppenheimer JJ, Casale TB. Next generation antihistamines: therapeutic rationale, accomplishments, and advances. Expert Opin Investig Drugs 2002;11(6):807-817
    • (2002) Expert Opin Investig Drugs , vol.11 , Issue.6 , pp. 807-817
    • Oppenheimer, J.J.1    Casale, T.B.2
  • 12
    • 0034978607 scopus 로고    scopus 로고
    • Olopatadine ophthalmic solution adjunctive to loratadine compared with loratadine alone in patients with active seasonal allergic conjunctivitis symptoms
    • Lanier BQ, Gross RD, Marks BB, et al. Olopatadine ophthalmic solution adjunctive to loratadine compared with loratadine alone in patients with active seasonal allergic conjunctivitis symptoms. Ann Allergy Asthma Immunol 2001;86(6):641-648
    • (2001) Ann Allergy Asthma Immunol , vol.86 , Issue.6 , pp. 641-648
    • Lanier, B.Q.1    Gross, R.D.2    Marks, B.B.3
  • 13
    • 33750326344 scopus 로고    scopus 로고
    • Epinastine in the management of ocular allergic disease
    • DOI 10.1097/01.iio.0000212128.45395.a5, PII 0000439720060464000011
    • Friedlaender MH. Epinastine in the management of ocular allergic disease. Int Ophthalmol Clin 2006;46(4):85-86 (Pubitemid 44632211)
    • (2006) International Ophthalmology Clinics , vol.46 , Issue.4 , pp. 85-86
    • Friedlaender, M.H.1
  • 14
    • 0023760095 scopus 로고
    • In vitro and in vivo studies of the non-sedating antihistamine epinastine
    • Fügner A, Bechtel WD, Kuhn FJ, Mierau J. In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung 1988;38(10):1446-1453
    • (1988) Arzneimittelforschung , vol.38 , Issue.10 , pp. 1446-1453
    • Fügner, A.1    Bechtel, W.D.2    Kuhn, F.J.3    Mierau, J.4
  • 15
    • 0028674662 scopus 로고
    • Accumulation of granulocytes in the lung and skin of guinea pigs. Inhibition by the anti-H1 antiallergic agent epinastine
    • Fügner A, Meissner C. Accumulation of granulocytes in the lung and skin of guinea pigs. Inhibition by the anti-H1 antiallergic agent epinastine. Arzneimittelforschung 1994;44(12):1338-1342
    • (1994) Arzneimittelforschung , vol.44 , Issue.12 , pp. 1338-1342
    • Fügner, A.1    Meissner, C.2
  • 17
    • 0025637670 scopus 로고
    • Antihistaminic activity and side effect profile of epinastine and terfenadine in healthy volunteers
    • Schilling JC, Adamus WS, Kuthan H. Antihistaminic activity and side effect profile of epinastine and terfenadine in healthy volunteers. Int J Clin Pharmacol Ther Toxicol 1990;28(12):493-497
    • (1990) Int J Clin Pharmacol Ther Toxicol , vol.28 , Issue.12 , pp. 493-497
    • Schilling, J.C.1    Adamus, W.S.2    Kuthan, H.3
  • 18
    • 0036776030 scopus 로고    scopus 로고
    • Dermal objective pharmacodynamic profile of cetirizine and epinastine: Two controlled randomised, double-blind, crossover studies
    • Leroy T, van Neste D. Dermal objective pharmacodynamic profile of cetirizine and epinastine: two controlled, randomised, double-blind, crossover studies. Int J Clin Pract 2002;56(8):568-573 (Pubitemid 35256388)
    • (2002) International Journal of Clinical Practice , vol.56 , Issue.8 , pp. 568-573
    • Leroy, T.1    Van Neste, D.2
  • 19
    • 0032837646 scopus 로고    scopus 로고
    • A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: Suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects
    • Grant JA, Danielson L, Rihoux JP, DeVos C. A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects. Allergy 1999;54(7):700-707
    • (1999) Allergy , vol.54 , Issue.7 , pp. 700-707
    • Grant, J.A.1    Danielson, L.2    Rihoux, J.P.3    Devos, C.4
  • 20
    • 0029087164 scopus 로고
    • Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes
    • Mita H, Shida T. Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. Arzneimittelforschung 1995;45(1):36-40
    • (1995) Arzneimittelforschung , vol.45 , Issue.1 , pp. 36-40
    • Mita, H.1    Shida, T.2
  • 21
    • 0034030735 scopus 로고    scopus 로고
    • In vitro investigations with the histamine H1 receptor antagonist, epinastine (WAL 801 CL), on isolated human allergic effector cells
    • Amon U, Gibbs BF, Buss G, Nitschke M. In vitro investigations with the histamine H1 receptor antagonist, epinastine (WAL 801 CL), on isolated human allergic effector cells. Inflamm Res 2000;49(3):112-116
    • (2000) Inflamm Res , vol.49 , Issue.3 , pp. 112-116
    • Amon, U.1    Gibbs, B.F.2    Buss, G.3    Nitschke, M.4
  • 22
    • 33748580279 scopus 로고    scopus 로고
    • Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells
    • DOI 10.1016/j.ejphar.2006.07.012, PII S0014299906007722
    • Hanashiro K, Sunagawa M, Tokeshi Y, et al. Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells. Eur J Pharmacol 2006;547(1-3):174-183 (Pubitemid 44373904)
    • (2006) European Journal of Pharmacology , vol.547 , Issue.1-3 , pp. 174-183
    • Hanashiro, K.1    Sunagawa, M.2    Tokeshi, Y.3    Nakasone, T.4    Ohta, S.5    Nakamura, M.6    Kosugi, T.7
  • 23
    • 0026572263 scopus 로고
    • Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition
    • Kamei C, Akagi M, Mio M, et al. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition. Immunopharmacol Immunotoxicol 1991;14(1-2):191-205
    • (1991) Immunopharmacol Immunotoxicol , vol.14 , Issue.1-2 , pp. 191-205
    • Kamei, C.1    Akagi, M.2    Mio, M.3
  • 24
    • 0025996757 scopus 로고
    • Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs
    • Misawa M, Kanai Y. Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. Arzneimittelforschung 1991;41(11):1145-1149
    • (1991) Arzneimittelforschung , vol.41 , Issue.11 , pp. 1145-1149
    • Misawa, M.1    Kanai, Y.2
  • 25
    • 0026589310 scopus 로고
    • Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects
    • Kamei C, Mio M, Kitazumi K, et al. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (II). Antagonistic effect of epinastine on chemical mediators, mainly antihistaminic and anti-PAF effects. Immunopharmacol Immunotoxicol 1992;14(1-2):207-218
    • (1992) Immunopharmacol Immunotoxicol , vol.14 , Issue.1-2 , pp. 207-218
    • Kamei, C.1    Mio, M.2    Kitazumi, K.3
  • 28
    • 22844433690 scopus 로고    scopus 로고
    • + T cells in-vitro
    • DOI 10.1211/0022357056640
    • Kanai K, Asano K, Hisamitsu T, Suzaki H. Suppressive activity of epinastine hydrochloride on TARC production from human peripheral blood CD4+ T cells in-vitro. J Pharm Pharmacol 2005;57(8):1027-1036 (Pubitemid 41039838)
    • (2005) Journal of Pharmacy and Pharmacology , vol.57 , Issue.8 , pp. 1027-1035
    • Kanai, K.-I.1    Asano, K.2    Hisamitsu, T.3    Suzaki, H.4
  • 29
    • 33645963967 scopus 로고    scopus 로고
    • Epinastine hydrochloride antagonism against interleukin-4-mediated T cell cytokine imbalance in vitro
    • Kanai K, Asano K, Watanabe S, et al. Epinastine hydrochloride antagonism against interleukin-4-mediated T cell cytokine imbalance in vitro. Int Arch Allergy Immunol 2006;140(1):43-52
    • (2006) Int Arch Allergy Immunol , vol.140 , Issue.1 , pp. 43-52
    • Kanai, K.1    Asano, K.2    Watanabe, S.3
  • 30
    • 35349027236 scopus 로고    scopus 로고
    • Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivo
    • DOI 10.1111/j.1365-2222.2007.02782.x
    • Galatowicz G, Ajayi Y, Stern ME, Calder VL. Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivo. Clin Exp Allergy 2007;37(11):1648-1656 (Pubitemid 47609843)
    • (2007) Clinical and Experimental Allergy , vol.37 , Issue.11 , pp. 1648-1656
    • Galatowicz, G.1    Ajayi, Y.2    Stern, M.E.3    Calder, V.L.4
  • 31
    • 0030965303 scopus 로고    scopus 로고
    • A comparative pharmacokinetic-pharmacodynamic study of the electrocardiographic effects of epinastine and terfenadine in rats
    • Ohtani H, Kotaki H, Sawada Y, Iga T. A comparative pharmacokineticpharmacodynamic study of the electrocardiographic effects of epinastine and terfenadine in rats. J Pharm Pharmacol 1997;49(4):458-462 (Pubitemid 27207704)
    • (1997) Journal of Pharmacy and Pharmacology , vol.49 , Issue.4 , pp. 458-462
    • Ohtani, H.1    Kotaki, H.2    Sawada, Y.3    Iga, T.4
  • 35
    • 33847718239 scopus 로고    scopus 로고
    • Distribution to the skin of epinastine hydrochloride in atopic dermatitis patients
    • DOI 10.1684/ejd.2007.0098
    • Toyoda M, Nakamura M, Nakagawa H. Distribution to the skin of epinastine hydrochloride in atopic dermatitis patients. Eur J Dermatol 2007;17(1):33-36 (Pubitemid 46383218)
    • (2007) European Journal of Dermatology , vol.17 , Issue.1 , pp. 33-36
    • Toyoda, M.1    Nakamura, M.2    Nakagawa, H.3
  • 36
    • 0034945745 scopus 로고    scopus 로고
    • Pharmacokinetics of epinastine and a possible mechanism for double peaks in oral plasma concentration profiles
    • DOI 10.1248/bpb.24.790
    • Ogiso T, Kasutani M, Tanaka H, et al. Pharmacokinetics of epinastine and a possible mechanism for double peaks in oral plasma concentration profiles. Biol Pharm Bull 2001;24(7):790-794 (Pubitemid 32633487)
    • (2001) Biological and Pharmaceutical Bulletin , vol.24 , Issue.7 , pp. 790-794
    • Ogiso, T.1    Kasutani, M.2    Tanaka, H.3    Iwaki, M.4    Tanino, T.5
  • 37
    • 1242272163 scopus 로고    scopus 로고
    • Efficacy and Tolerability of Ophthalmic Epinastine: A Randomized, Double-Masked, Parallel-Group, Active-and Vehicle-Controlled Environmental Trial in Patients with Seasonal Allergic Conjunctivitis
    • DOI 10.1016/S0149-2918(04)90003-3
    • Whitcup SM, Bradford R, Lue J, et al. Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active- and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis. Clin Ther 2004;26(1):29-34 (Pubitemid 38241520)
    • (2004) Clinical Therapeutics , vol.26 , Issue.1 , pp. 29-34
    • Whitcup, S.M.1    Bradford, R.2    Lue, J.3    Schiffman, R.M.4    Abelson, M.B.5
  • 38
    • 1242294540 scopus 로고    scopus 로고
    • Efficacy and Tolerability of Ophthalmic Epinastine Assessed Using the Conjunctival Antigen Challenge Model in Patients with a History of Allergic Conjunctivitis
    • DOI 10.1016/S0149-2918(04)90004-5
    • Abelson MB, Gomes P, Crampton HJ, et al. Efficacy and tolerability of ophthalmic epinastine assessed using the conjunctival antigen challenge model in patients with a history of allergic conjunctivitis. Clin Ther 2004;26(1):35-47 (Pubitemid 38241521)
    • (2004) Clinical Therapeutics , vol.26 , Issue.1 , pp. 35-47
    • Abelson, M.B.1    Gomes, P.2    Crampton, H.J.3    Schiffman, R.M.4    Bradford, R.R.5    Whitcup, S.M.6
  • 41
    • 33845203842 scopus 로고    scopus 로고
    • Efficacy and response with olopatadine versus epinastine in ocular allergic symptoms: A post hoc analysis of data from a conjunctival allergen challenge study
    • DOI 10.1016/j.clinthera.2006.10.003, PII S0149291806002438
    • Finegold I, Granet DB, D'Arienzo PA, Epstein AB. Efficacy and response with olopatadine versus epinastine in ocular allergic symptoms: a post hoc analysis of data from a conjunctival allergen challenge study. Clin Ther 2006;28(10):1630-1638 (Pubitemid 44848366)
    • (2006) Clinical Therapeutics , vol.28 , Issue.10 , pp. 1630-1638
    • Finegold, I.1    Granet, D.B.2    D'Arienzo, P.A.3    Epstein, A.B.4
  • 42
    • 34347262074 scopus 로고    scopus 로고
    • Efficacy and comfort of olopatadine 0.2% versus epinastine 0.05% ophthalmic solution for treating itching and redness induced by conjunctival allergen challenge
    • Mah FS, Rosenwasser LJ, Townsend WD, et al. Efficacy and comfort of olopatadine 0.2% versus epinastine 0.05% ophthalmic solution for treating itching and redness induced by conjunctival allergen challenge. Curr Med Res Opin 2007;23(6):1445-1452
    • (2007) Curr Med Res Opin , vol.23 , Issue.6 , pp. 1445-1452
    • Mah, F.S.1    Rosenwasser, L.J.2    Townsend, W.D.3
  • 44
    • 0028206823 scopus 로고
    • Inhibitory effect of epinastine on bronchoconstriction induced by histamine, platelet activating factor serotonin in guinea pigs and rats
    • Tasaka K, Kamei C, Nakamura S. Inhibitory effect of epinastine on bronchoconstriction induced by histamine, platelet activating factor and serotonin in guinea pigs and rats. Arzneimittelforschung 1994;44(3):327-329 (Pubitemid 24102558)
    • (1994) Arzneimittel-Forschung/Drug Research , vol.44 , Issue.3 , pp. 327-329
    • Tasaka, K.1    Kamei, C.2    Nakamura, S.3
  • 45
    • 33750369448 scopus 로고    scopus 로고
    • Elestat (epinastine HCl ophthalmic solution 0.05%) as a therapeutic for allergic conjunctivitis
    • DOI 10.1097/01.iio.0000212136.77675.b1, PII 0000439720060464000012
    • Trattler WB, Luchs J, Majmudar P. Elestat (epinastine HCl ophthalmic solution 0.05%) as a therapeutic for allergic conjunctivitis. Int Ophthalmol Clin 2006;46(4):87-99 (Pubitemid 44632212)
    • (2006) International Ophthalmology Clinics , vol.46 , Issue.4 , pp. 87-99
    • Trattler, W.B.1    Luchs, J.2    Majmudar, P.3
  • 46
    • 34347330146 scopus 로고    scopus 로고
    • An open-label, investigator-masked, crossover study of the ocular drying effects of two antihistamines, topical epinastine and systemic loratadine, in adult volunteers with seasonal allergic conjunctivitis
    • Ousler GW 3rd, Workman DA, Torkildsen GL. An open-label, investigator-masked, crossover study of the ocular drying effects of two antihistamines, topical epinastine and systemic loratadine, in adult volunteers with seasonal allergic conjunctivitis. Clin Ther 2007;29(4):611-616
    • (2007) Clin Ther , vol.29 , Issue.4 , pp. 611-616
    • Ousler III, G.W.1    Workman, D.A.2    Torkildsen, G.L.3
  • 47
    • 48549104822 scopus 로고    scopus 로고
    • Ocular comfort and drying effects of three topical antihistamine/mast cell stabilizers in adults with allergic conjunctivitis: A randomized, double-masked crossover study
    • Torkildsen GL, Ousler GW, Gomes P. Ocular comfort and drying effects of three topical antihistamine/mast cell stabilizers in adults with allergic conjunctivitis: a randomized, double-masked crossover study. Clin Ther 2008;30(7):1264-1271
    • (2008) Clin Ther , vol.30 , Issue.7 , pp. 1264-1271
    • Torkildsen, G.L.1    Ousler, G.W.2    Gomes, P.3
  • 48
    • 33751018555 scopus 로고    scopus 로고
    • Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice
    • DOI 10.1097/01.icl.0000224360.10319.b1, PII 0014006820061200000005
    • Villareal AL, Farley W, Pflugfelder SC. Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice. Eye & Contact Lens. Sci Clin Pract 2006;32(6):272-276 (Pubitemid 44747200)
    • (2006) Eye and Contact Lens , vol.32 , Issue.6 , pp. 272-276
    • Villareal, A.L.1    Farley, W.2    Pflugfelder, S.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.