Adult; Child; Epinastine; Paediatric dosage; Population pharmacokinetics
Indexed keywords
EPINASTINE;
HISTAMINE H1 RECEPTOR ANTAGONIST;
ADOLESCENT;
ADULT;
AREA UNDER THE CURVE;
ARTICLE;
ATOPIC DERMATITIS;
BODY WEIGHT;
CHILD;
CLINICAL TRIAL;
COMPARTMENT MODEL;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
COVARIANCE;
CROSSOVER PROCEDURE;
DATA ANALYSIS;
DRUG ABSORPTION;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
DRUG CLEARANCE;
DRUG DISTRIBUTION;
DRUG DOSE REGIMEN;
DRUG EXPOSURE;
DRUG FORMULATION;
DRUG SAFETY;
FEMALE;
FIRST PASS EFFECT;
FOOD DRUG INTERACTION;
HUMAN;
MAJOR CLINICAL STUDY;
MALE;
MATHEMATICAL MODEL;
OPEN STUDY;
PHASE 3 CLINICAL TRIAL;
POPULATION PHARMACOKINETIC MODEL;
POPULATION RESEARCH;
PRIORITY JOURNAL;
STATISTICAL MODEL;
STATISTICAL SIGNIFICANCE;
VOLUNTEER;
ADULT;
AREA UNDER CURVE;
CHILD;
CHILD, PRESCHOOL;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CROSS-OVER STUDIES;
DERMATITIS, ATOPIC;
DIBENZAZEPINES;
DOSE-RESPONSE RELATIONSHIP, DRUG;
FEMALE;
HISTAMINE H1 ANTAGONISTS;
HUMANS;
IMIDAZOLES;
INFANT;
MALE;
TIME FACTORS;
In vitro and in vivo studies of the non-sedating antihistamine epinastine
Fugner A, Bechtel WD, Kuhn FJ, Mierau J. In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung 1988; 38: 1446-53.
Double-blind comparative study of epinastine dry syrup with ketotifen dry syrup in children with perennial allergic rhinitis
Okuda M, Okubo K. Double-blind comparative study of epinastine dry syrup with ketotifen dry syrup in children with perennial allergic rhinitis [written in Japanese, abstract in English]. Zibi Rinsyo Supplement 2003; 114: 1-21.
Positron emission tomographic study of central histamine H1-receptor occupancy in human subjects treated with epinastine, a second-generation antihistamine
Yanai K, Ryu JH, Watanabe T, et al. Positron emission tomographic study of central histamine H1-receptor occupancy in human subjects treated with epinastine, a second-generation antihistamine. Meth Find Exp Clin Pharmacol 1995; 17(Suppl C): 64-9.
Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography
Yanai K, Ryu JH, Watanabe T, et al. Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography. Br J Pharmacol 1995; 116: 1649-55.
Epinastine: An update of its pharmacology, metabolism, clinical efficacy and tolerability in the treatment of allergic diseases
Tasaka K. Epinastine: An update of its pharmacology, metabolism, clinical efficacy and tolerability in the treatment of allergic diseases. Drugs Today (Barc) 2000; 36: 735-57.
Note for Guidance on Clinical Investigation of Medicinal Products in Children. CPMP/EWP/462/95 1997. Available at: http://www.emea.eu.int/pdfs/human/ ich/271199EN.pdf. Last accessed 14 October 2004.
Clinical investigation of medicinal products in the pediatric population. ICH harmonised tripartite guideline 2000. Available at: http://www.fda.gov/ cder/guidance/4099FNL.PDF. Last accessed 14 October 2004.
Phase III Open-labeled study of epinastine hydrochloride dry syrup in pediatric patients with atopic dermatitis - Evaluation of safety for 3 months administration
Harada S, Nakagawa H, Onoda S, et al. Phase III Open-labeled study of epinastine hydrochloride dry syrup in pediatric patients with atopic dermatitis -evaluation of safety for 3 months administration- [written in Japanese, abstract in English]. Rinsyoiyaku 2003; 19: 1307-25.
