Mechanism for myocardial localization and rapid liver clearance of Tc-99m-N-MPO: A new perfusion radiotracer for heart imaging

Journal of Nuclear Cardiology

Volumn 16, Issue 4, 2009, Pages 571-579

  Kim, Young Seung ^a   Shi, Jiyun ^a   Zhai, Shizhen ^a   Hou, Guihua ^a   Liu, Shuang ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Cationic Tc 99m radiotracers; Myocardial perfusion imaging; Tc 99m N MPO

Indexed keywords

2 MERCAPTOPYRIDINE N OXIDE N ETHOXYETHYL N,N BIS [2 [BIS (3 METHOXYPROPYL)PHOSPHINO]ETHYL]AMINE TC 99M; CYCLOSPORIN A; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG STRUCTURE; FEMALE; HEART MUSCLE PERFUSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGING SYSTEM; ISOLATED HEART; KIDNEY; LIVER; LIVER CELL; MALE; MITOCHONDRION; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT;

ANIMALS; CYCLOSPORINE; FEMALE; HEART; HEPATOCYTES; KIDNEY; KINETICS; LIVER; MALE; MODELS, CHEMICAL; MYOCARDIUM; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 70249098476     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12350-009-9068-y     Document Type: Article

References (44)

1. Jain D. Technetium-99m labeled myocardial perfusion imaging agents. Semin Nucl Med 1999;29:221-36.
2. Acampa W, Di Benedetto C, Cuocolo A. An overview of radiotracers in nuclear cardiology. J Nucl Cardiol 2000;7:701-7.
3. Dilsizian V. The role of myocardial perfusion imaging in vascular endothelial dysfunction. J Nucl Cardiol 2000;7:180-4.
4. Beller GA, Zaret BL. Contributions of nuclear cardiology to diagnosis and prognosis of patients with coronary artery disease. Circulation 2000;101:1465-78.
5. Russell RR, Zaret BL. Nuclear cardiology: Present and future. Curr Probl Cardiol 2006;31:557-629.
6. Banerjee S, Pillai MRA, Ramamoorthy N. Evolution of Tc-99m in diagnostic radiopharmaceuticals. Semin Nucl Med 2001;31:260-77.
7. Parker JA. Cardiac nuclear medicine in monitoring patients with coronary heart disease. Semin Nucl Med 2001;31:223-37.
8. Kapur A, Latus KA, Davies G, Dhawan RT, Eastick S, Jarritt PH, et al. A comparison of three radionuclide myocardial perfusion tracers in clinical practice: The ROBUST study. Eur J Nucl Med 2002;29:1608-16.
9. Kailasnath P, Sinusas AJ. Comparison of Tl-201 with Tc-99m-labeled myocardial perfusion agents: Technical, physiological, and clinical issues. J Nucl Cardiol 2001;8:482-98.
10. Llaurado JG. The quest for the perfect myocardial perfusion indicator...still a long way to go. J Nucl Med 2001;42:282-4.
11. Ward RP, Al-Mallah MH, Grossman GB, Hansen CL, Hendel RC, Kerwin TC, et al. American Society of Nuclear Cardiology review of the ACCF/ASNC appropriateness criteria for single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI). J Nucl Cardiol 2007;14:e26-38.
12. Cerqueira MD, Garcia EV, Gropler RJ, Udelson JE. Eighth nuclear cardiology invitational conference, Park City, Utah, 2006. J Nucl Cardiol 2007;14:e15-25.
13. Garcia EV, Gropler RJ. Ninth nuclear cardiology invitational conference, Annapolis, Maryland, 2008. J Nucl Cardiol 2008;15:e37-50.
14. Jones AG, Abrams MJ, Davison A, Brodack JW, Toothaker AK, Adelstein SJ, et al. Biological studies of a new class of technetium complexes: The hexakis(alkylisonitrile)technetium(I) cations. Int J Nucl Biol 1984;11:225-34.
15. Marmion ME, Woulfe SR, Neumann WL, Nosco DL, Deutsch E. Preparation and characterization of technetium complexes with Schiff-base and phosphine coordination. 1. Complexes of technetium-99g and -99m with substituted acac2en and trialkyl phosphines (where acac2en = N, N'-ethylenebis[acetylacetone iminato]). Nucl Med Biol 1999;26:755-70.
16. 99mTc-nitride heterocomplexes showing high heart uptake and improved imaging properties. J Nucl Med 2003;44:806-14.
17. 99mTc-Tetrofosmin in rats. J Nucl Med 2004;45:2095-101.
18. Hatada K, Ruiz M, Riou LM, Lima RL, Goode AR, Watson DD, et al. Organ distribution and myocardial uptake, washout, and redistribution kinetics of Tc-99mN-DBODC5 when injected during vasodilator stress in canine models of coronary stenoses. J Nucl Cardiol 2006;13:779-90.
19. 99mTc-N-DBODC. J Nucl Med 2008;49:1299-304.
20. 99mTc-nitrido complexes. Bioconj Chem 2007;18:929-36.
21. 99mTc-nitrido complex useful for myocardial perfusion imaging. J Nucl Cardiol 2008;15:535-46.
22. 99mTc complexes useful as radiopharmaceuticals for heart imaging. Dalton Trans 2007;1183-93
23. 99mTc-nitrido complexes radiopharmaceuticals for heart imaging: Improving liver clearance with crown ether groups. Nucl Med Biol 2006;33:419-32.
24. 99mTc radiotracers. Inorg Chim Acta 2006;359:2479-88.
25. 99mTc(I)-tricarbonyl complexes as potential radiotracers for myocardial perfusion imaging. Nucl Med Biol 2006;33:1045-53.
26. 99mTc-labeling of small biomolecules. Bioconj Chem 2006;17:473-84.
27. 99m TcN-15C5 as a new myocardial perfusion imaging agent in normal dogs and canines with coronary stenoses. Nucl Med Commun 2008;29:775-81.
28. Qadir M, O'Loughlin KL, Fricke SM, Williamson NA, Greco WR, Minderman H, et al. Cyclosporin A is a broad-spectrum multidrug resistance modulator. Clin Cancer Res 2005;11:2320-6.
29. Carvalho PA, Chiu ML, Kronauge JF, Kawamura M, Jones AG, Holman BL, et al. Subcellular distribution and analysis of technetium-99m-MIBI in isolated perfused rat hearts. J Nucl Med 1992;33:1516-21.
30. +. J Nucl Med 2008;49:1336-44.
31. Ochoa S. Malic dehydrogenase from pig heart. Methods Enzymol 1955;1:735-9.
32. Younes A, Songadele JA, Maublant J, Platts E, Pickett R, Veyre A. Mechanism of uptake of technetium-tetrofosmin II: Uptake into isolated adult rat heart mitochondria. J Nucl Cardiol 1995;2:327-33.
33. Piwnica-Worms D, Kronauge JF, Chiu ML. Uptake and retention of hexakis(2-methoxyisobutylisonitrile) technetium(I) in cultured chick myocardial cells: Mitochondrial and plasma membrane potential dependence. Circulation 1990;82:1826-38.
34. Duchen MR. Mitochondria in health and disease: Perspectives on a new mitochondrial biology. Mol Aspects Med 2004;25:365-451.
35. 99mTc-MIBI in the evaluation of breast cancer biology. Eur J Nucl Med Mol Imaging 2004;31:S88-96.
36. 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system. Nucl Med Biol 2004;31:53-65.
37. 99mTc-labeled sestamibi and tetrofosmin. Nucl Med Biol 2005;32:573-83.
38. Sharma V. Radiopharmaceuticals for assessment of multidrug resistance P-glycoprotein-mediated drug transport activity. Bioconj Chem 2004;15:1464-74.
39. Vaidyanathan G, Zalutsky MR. Imaging drug resistance with radiolabeled molecules. Current Pharm Design 2004;10:2965-79.
40. Sharma V, Piwnica-Worms D. Monitoring multidrug resistance P-glycoprotein drug transport activity with singlephoton emission computed tomography and positron emission tomography radiopharmaceuticals. Top Curr Chem 2005;252:155-78.
41. Gatmaitan ZC, Arias IM. Structure and function of P-glycoprotein in normal liver and small intestine. Adv Pharmacol 1993;24:77-97.
42. Lee CH, Bradley G, Zhang JT, Ling V. Differential expression of P-glycoprotein genes in primary rat hepatocytes culture. J Cell Physiol 1993;157:392-402.
43. Mayer R, Kartenbeck J, Buchler M, Jedlitschky G, Leier I, Keppler D. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport deficient mutant hepatocytes. J Cell Biol 1995;131:137-50.
44. 99mTc-Sestamibi accumulation in normal liver and drug resistant-tumors after the administration of the glycoprotein inhibitor, XR9576. Clin Cancer Res 2003;9:650-6.