Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenoses

Journal of Nuclear Cardiology

Volumn 13, Issue 6, 2006, Pages 779-790

  Hatada, Kengo ^a   Ruiz, Mirta ^b   Riou, Laurent M ^c   Lima, Ronaldo L ^d   Goode, Allen R ^b   Watson, Denny D ^b   Beller, George A ^b   Glover, David K ^b  

^a KANSAI MEDICAL UNIVERSITY MEDICAL CENTER   (Japan)

^b UNIVERSITY OF VIRGINIA   (United States)

^c INSERM   (France)

^d FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

biodistribution; extraction; liver clearance; Radioisotopes; redistribution; technetium

Indexed keywords

[BIS(DIMETHOXYPROPYLPHOSPHINOETHYL)ETHOXYETHYLAMINE][BIS(N ETHOXYETHYL)DITHIOCARBAMATO]NITRIDE TC 99M; ADENOSINE; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; MICROSPHERE; RADIOPHARMACEUTICAL AGENT; TETROFOSMIN TC 99M; THALLIUM 201;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DISEASE SEVERITY; DOG; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG UPTAKE; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE PERFUSION; HEART SCINTISCANNING; HEMODYNAMICS; HYPEREMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIVER CLEARANCE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; VASODILATATION;

ADENOSINE; ANIMALS; CORONARY STENOSIS; DISEASE MODELS, ANIMAL; DOGS; INJECTIONS; INJECTIONS, INTRA-ARTERIAL; METABOLIC CLEARANCE RATE; MYOCARDIUM; ORGAN SPECIFICITY; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; VASODILATOR AGENTS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 33845505731     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nuclcard.2006.08.016     Document Type: Article

References (28)

1. Boschi A., Bolzati C., Uccelli L., et al. A class of asymmetrical nitrido 99mTc heterocomplexes as heart imaging agents with improved biological properties. Nucl Med Commun 23 (2002) 689-693
2. Boschi A., Uccelli L., Bolzati C., et al. Synthesis and biologic evaluation of monocationic asymmetric 99mTc-nitride heterocomplexes showing high heart uptake and improved imaging properties. J Nucl Med 44 (2003) 806-814
3. 99mTc-tetrofosmin in rats. J Nucl Med 45 (2004) 2095-2101
4. Wackers F.J., Berman D.S., Maddahi J., et al. Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 30 (1989) 301-311
5. Higley B., Smith F.W., Smith T., et al. Technetium-99m-1,2-bis[bis(2-ethoxyethyl) phosphino]ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent. J Nucl Med 34 (1993) 30-38
6. Jain D., Wackers F.J., Mattera J., McMahon M., Sinusas A.J., and Zaret B.L. Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one-day imaging protocol. J Nucl Med 34 (1993) 1254-1259
7. O'Connor M.K., and Kelly B.J. Evaluation of techniques for the elimination of "hot" bladder artifacts in SPECT of the pelvis. J Nucl Med 31 (1990) 1872-1875
8. Chua T., Kiat H., Germano G., et al. Rapid back to back adenosine stress/rest technetium-99m teboroxime myocardial perfusion SPECT using a triple-detector camera. J Nucl Med 34 (1993) 1485-1493
9. Germano G., Chua T., Kiat H., Areeda J.S., and Berman D.S. A quantitative phantom analysis of artifacts due to hepatic activity in technetium-99m myocardial perfusion SPECT studies. J Nucl Med 35 (1994) 356-359
10. Nuyts J., Dupont P., Van den Maegdenbergh V., Vleugels S., Suetens P., and Mortelmans L. A study of the liver-heart artifact in emission tomography. J Nucl Med 36 (1995) 133-139
11. Matsunari I., Tanishima Y., Taki J., et al. Early and delayed technetium-99m-tetrofosmin myocardial SPECT compared in normal volunteers. J Nucl Med 37 (1996) 1622-1626
12. Kailasnath P., and Sinusas A.J. Comparison of Tl-201 with Tc-99m-labeled myocardial perfusion agents: technical, physiologic, and clinical issues. J Nucl Cardiol 8 (2001) 482-498
13. Moore C.A., Cannon J., Watson D.D., Kaul S., and Beller G.A. Thallium 201 kinetics in stunned myocardium characterized by severe postischemic systolic dysfunction. Circulation 81 (1990) 1622-1632
14. Glover D.K., Ruiz M., Yang J.Y., Smith W.H., Watson D.D., and Beller G.A. Myocardial 99mTc-tetrofosmin uptake during adenosine-induced vasodilatation with either a critical or mild coronary stenosis: comparison with 201Tl and regional myocardial blood flow. Circulation 96 (1997) 2332-2338
15. Glover D.K., Ruiz M., Takehana K., et al. Pharmacological stress myocardial perfusion imaging with the potent and selective A(2A) adenosine receptor agonists ATL193 and ATL146e administered by either intravenous infusion or bolus injection. Circulation 104 (2001) 1181-1187
16. Glover D.K., Ruiz M., Edwards N.C., et al. Comparison between 201Tl and 99mTc sestamibi uptake during adenosine-induced vasodilation as a function of coronary stenosis severity. Circulation 91 (1995) 813-820
17. Smith W.H., and Watson D.D. Technical aspects of myocardial planar imaging with technetium-99m sestamibi. Am J Cardiol 66 (1990) 16E-22E
18. Sinusas A.J., Beller G.A., Smith W.H., Vinson E.L., Brookeman V., and Watson D.D. Quantitative planar imaging with technetium-99m methoxyisobutyl isonitrile: comparison of uptake patterns with thallium-201. J Nucl Med 30 (1989) 1456-1463
19. Heymann M.A., Payne B.D., Hoffman J.I., and Rudolph A.M. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 20 (1977) 55-79
20. Jain D. Technetium-99m labeled myocardial perfusion imaging agents. Semin Nucl Med 29 (1999) 221-236
21. Okada R.D., Glover D., Gaffney T., and Williams S. Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile. Circulation 77 (1988) 491-498
22. Kelly J.D., Forster A.M., Higley B., et al. Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging. J Nucl Med 34 (1993) 222-227
23. Nakajima K., Taki J., Shuke N., Bunko H., Takata S., and Hisada K. Myocardial perfusion imaging and dynamic analysis with technetium-99m tetrofosmin. J Nucl Med 34 (1993) 1478-1484
24. Schwaiger M., and Melin J. Cardiological applications of nuclear medicine. Lancet 354 (1999) 661-666
25. Sansoy V., Glover D.K., Watson D.D., et al. Comparison of thallium-201 resting redistribution with technetium-99m-sestamibi uptake and functional response to dobutamine for assessment of myocardial viability. Circulation 92 (1995) 994-1004
26. Glover D.K., and Okada R.D. Myocardial technetium 99m sestamibi kinetics after reperfusion in a canine model. Am Heart J 125 (1993) 657-666
27. Mousa S.A., Cooney J.M., and Williams S.J. Relationship between regional myocardial blood flow and the distribution of 99mTc-sestamibi in the presence of total coronary artery occlusion. Am Heart J 119 (1990) 842-847
28. Gosselin R.E., and Stibitz G.R. Rates of solute absorption from tissue depots: theoretical considerations. Pflugers Arch 318 (1970) 85-98