Immune responses in autoimmune hepatitis: Effect of prednisone and azathioprine treatment: Case report

International Journal of Medical Sciences

Volumn 6, Issue 4, 2009, Pages 177-183

  Bluth, Martin H ^a   Kohlhoff, Stephan ^b,c   Norowitz, Kevin B ^b   Silverberg, Jonathan I ^c   Chice, Seto ^c   Nowakowski, M ^c   Durkin, Helen G ^c   Smith Norowitz, Tamar A ^b,c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SUNY Downstate Medical Center   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Autoimmune hepatitis; Azathioprine treatment; Immunoglobulin E (IgE)

Indexed keywords

AZATHIOPRINE; CD16 ANTIGEN; CD19 ANTIGEN; CD23 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; FAMOTIDINE; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 12; INTERLEUKIN 4; PREDNISONE; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; GLUCOCORTICOID; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ARTICLE; AUTOIMMUNE HEPATITIS; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DRUG DOSE REDUCTION; DRUG EFFECT; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; LIVER BIOPSY; LIVER FUNCTION TEST; NEPHELOMETRY; BLOOD; CD4 LYMPHOCYTE COUNT;

ADOLESCENT; AZATHIOPRINE; CD4 LYMPHOCYTE COUNT; CYTOKINES; FEMALE; GLUCOCORTICOIDS; HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNOGLOBULINS; IMMUNOSUPPRESSIVE AGENTS; LIVER FUNCTION TESTS; PREDNISONE;

EID: 70249096322     PISSN: None     EISSN: 14491907     Source Type: Journal    
DOI: 10.7150/ijms.6.177     Document Type: Article

References (29)

1. Maggiore G, Riva S, Sciveres M. Autoimmune diseases of the liver and biliary tract and overlap syndromes in childhood. Minerva Gastroenterol Dietol. 2009; 55: 53-70.
2. Buxbaum J, Qian P, Allen PM, Peters MG. Hepatitis resulting from liver-specific expression and recognition of self-antigen. J Autoimmun. 2008; 31: 208-215.
3. Maggs J, Cullen S. Management of autoimmune liver disease. Minerva Gaastroenterol Dietol. 2009; 55: 173-206.
4. Derkow K, Loddenkemper C, Mintern J, Kruse N, Klugewitz K, Berg T, Wiedenmann B, et al. Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis. Hepatology. 2007; 46: 1155-1165. (Pubitemid 350144780)
5. Vergani D, Mieli-Vergani G. Aetiopathogenesis of autoimmune hepatitis. World J Gastroenterol. 2008; 14: 3306-3312.
6. Gonzalez-Quintela A, Alende MR, Lojo S, Perez LF, Padin E, Tome S, Vidal C. Total serum IgE levels in chronic hepatitis C: influence of interferon alpha therapy. Int Arch Allergy Immunol. 2001; 125: 176-181. (Pubitemid 32642056)
7. Minuk GY, Boyd ND, matheson DS, Fritzler MJ, Green BJ. Serum immunoglobulin E levels in patients with primary biliary cirrhosis. J Allergy Clin Immunol. 1989; 83: 462-463.
8. Krawitt EL. Autoimmune hepatitis. N Engl J Med. 2006; 351: 54-66.
9. Teufel A, Galle PR, Kanzler S. Update on autoimmune hepatitis. World J Gastroenterol. 2009; 15(9): 1035-1041.
10. Johnson PJ, McFarlane IG, Williams R. Azathioprine for long-term maintenance of remission in autoimmune hepatitis. N Engl J Med 1995; 333: 958-963.
11. Fernandes NF, Redeker AG, Vierling JM, Villamil FG, Fong TL. Cyclosporine therapy in patients with stero autoimmune hepatitis. Am J Gastroenterol. 1999; 94: 241-248. (Pubitemid 29063476)
12. Alvarez F, Ciocca-Velasco C, Ramonet M, de Davila MT, Cuarterolo M, Gonzalez T, Jara-Vega C, Brochu P, Drut R, Alvarez E. Short term cyclosporine induces a remission of autoimmune hepatitis in children. J Hepatology. 1999; 30: 222-227. (Pubitemid 29071183)
13. Manns MP, Bahr MJ, Woynarowski M, Kreisel W, Oren R, Gunther R, Hultcrantz R, Proels M, Rust C, et al. Budenoside 3mg tid is superior to prednisone in combination with azathioprine in the treatment of autoimmune hepatitis. J Hepatol 2008; 2: S369.
14. Czaja AJ. Autoimmune hepatitis. Part A: Pathogenesis. Expert Rev Gastroenterol Hepatol 2007; 1(1): 113-128.
15. Mieli-Vergani G, Vergani D. Autoimmune paediatric liver disease. World J Gastroenterol. 2008; 14(21): 3360-3367.
16. Bravo Soto JA, Esteban de la Rosa RJ, Luna del Castillo JD, Cerezo Morales S, García Olivares E, Osuna Ortega A, Asensio Peinado C. Effect of mycophenolate mofetil regimen on peripheral blood lymphocyte subsets in kidney transplant recipients. Transplant Proc. 2003;35:1355-1359 (Pubitemid 36765530)
17. Arnold B, Schonrich G, Hammerling GJ. Multiple levels of peripheral tolerance. Immunol Today 1993; 14: 12-14.
18. von Boehmer H, Kisielow P. Lymphocyte lineage commitment: instruction versus selection. Cell 1993; 73: 207-208. (Pubitemid 23123298)
19. Lider O, Reshef T, Beraud E, Ben-Nun A, Cohen IR. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 1989; 239: 181-183.
20. Sun D, Quin Y, Chluba J, Eppen JT, Wekerle H. Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T-T cell interactions. Nature 1988; 332: 842-844. (Pubitemid 18136875)
21. Lohse AW, Mor F, Karin N, Cohen IR. Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells. Science 1989; 244: 82-822. (Pubitemid 19163870)
22. Lohr HF, Schlaak JF, Lohse AW, Bocher WO, Arenz M, Gerken G, Meyer Zum Buschenfelde KH. Autoreactive CD4+ LKH-specific and anticlonotypic T-cell responses in LKM-1 antibody- positive autoimmune hepatitis. Hepatology. 1996; 24(6): 1416-1421.
23. Lohr HF, Schlaak J, Fleischer B, Dienes HP, Meyer zum Buschenfelde K-H, Gerken G. Phenotypical characterisatoin and cytokine release of analysis of peripheral blood and liver infiltrating T cells from patients with chronic hepatitis. Liver 1994; 14: 161-166.
24. Schlaak JF, Lohr HF, Gallati H, Meyer zum Buschenfelde K-H, Fleischer B. Analysis of the in vitro cytokine production by liver-infiltrating T cells of patients with autoimmune hepatitis. Clin Exp Immunol 1993; 94: 168-173.
25. Mix H, Weiler-Normann C, Thimme R, Ahlenstiel G, Shin EC, Herkel J, David CS, Lohse AW, Rehermann B. Identification of CD4+ T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis. Gastroenterology 2008; 135 (6): 2107-2118.
26. Eggink HF, Houthoff HJ, Huhema S, Gips CH, Poppema S. Cellular and humoral immune reactions in chronic active liver disease. Lymphocyte subsets in liver biopsies of patinets with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis. Clin Exp Immunol 1982; 50: 17-24.
27. Lobo-Yeo A, Senaldi G, Portman B, Mowat AP, Mieli-Vergani G, Vergani D. Class I and class I major histocimpatibility complex antigen expression on hepatocytes: a study in children with liver disease. Hepatology 1990; 12: 224-232. (Pubitemid 20285784)
28. Bansal AS, Bruce J, Hogan PG, Prichard P, Powell EE. Serum soluble CD23 but not IL- 8, IL-10, GM-CSF, or IFN-gamma is elevated in patients with hepatitis C infection. Clin Immunol Immunopathol. 1997; 84(2): 139-144. (Pubitemid 27353464)
29. Hassan AA, Zaki M, Shoukeir M, Khalil R. T-helper subsets cytokine production in kidney transplant recipients: diverting influences and impact on graft outcome. Saudi J Kidney Dis Transpl. 2000; 11:161-166