Predicting hepatic disposition properties of cationic drugs using a physiologically based, agent-oriented In Silico Liver

Proceedings of the 2008 Spring Simulation Multiconference, SpringSim'08

Volumn , Issue , 2008, Pages 162-169

  Yan, Li ^a   Park, Sunwoo ^b   Sheikh Bahaei, Shahab ^a   Ropella, Glen E P ^b,c   Hunt, C Anthony ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b San Francisco   (United States)

^c TEMPUS DICTUM INC   (United States)

Author keywords

Agent oriented; Drug disposition; Hepatic; Mechanistic; Physiologically based; Prediction; Systems biology

Indexed keywords

AGENT ORIENTED; DRUG DISPOSITION; HEPATIC; MECHANISTIC; PHYSIOLOGICALLY-BASED; PREDICTION; SYSTEMS BIOLOGY;

BACKPROPAGATION; BIOLOGY; NEURAL NETWORKS; SUGAR (SUCROSE);

LIVER;

EID: 70249091805     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1145/1400549.1400569     Document Type: Conference Paper

References (7)

1. Hunt CA, Ropella GE, Yan L, Hung DY and Roberts MS (2006) Physiologically based synthetic models of hepatic disposition. J Pharmacokinet Pharmacodyn 33: 737-72.
2. Yan L, Ropella GEP, Park S, Roberts MS and Hunt CA (2007) Modeling and Simulation of Hepatic Drug Disposition Using a Physiologically Based, Multi-Agent In Silico Liver. Pharm Res Published online: 28 November 2007 (DOI: 10.1007/sll095-007-9494-y).
3. Fagerholm U. (2007) Prediction of human pharmacoki-netics - evaluation of methods for prediction of hepatic metabolic clearance. J Pharm Pharmacol 59: 803-28.
4. Hudson DL and Cohen ME (1999) Neural Networks and Artificial Intelligence for Biomedical Engineering (IEEE Press Series on Biomed Engineering). Wiley-IEEE Press.
5. Theil FP, Guentert TW, Haddad S, Poulin P (2003) Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxicol Lett 138: 29-49.
6. Hung DY, Chang P, Weiss M and Roberts MS (2001) Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process. J Pharmacol Exp Ther 297:780-789.
7. Yan L, Sheihk-Bahaei S, Park S, Ropella GEP and Hunt CA (2008) Predictions of Hepatic Disposition Properties Using a Mechanistically Realistic, Physiologically Based Model. Drug Metab Dispos doi:10.1124/dmd. 107.019067.