Activation of FcγRI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses

Journal of Immunology

Volumn 183, Issue 4, 2009, Pages 2349-2355

  Tanaka, Motoyuki ^a   Krutzik, Stephan R ^a   Sieling, Peter A ^a   Lee, Delphine J ^a   Rea, Thomas H ^b   Modlin, Robert L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD14 ANTIGEN; CD1B ANTIGEN; CD32 ANTIGEN; CD64 ANTIGEN; CD86 ANTIGEN; FC GAMMA RECEPTOR I; FC RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG; AUTACOID; CD1 ANTIGEN; CD209 ANTIGEN; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; DC-SPECIFIC ICAM-3 GRABBING NONINTEGRIN; FCGR1A PROTEIN, HUMAN; LECTIN;

ANTIGEN PRESENTING CELL; ARTICLE; AUTOLOGOUS MIXED LYMPHOCYTE REACTION; CELL DIFFERENTIATION; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE COMPLEX DISEASE; IMMUNE RESPONSE; MIXED LYMPHOCYTE REACTION; MONOCYTE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION; AUTOIMMUNE DISEASE; BIOSYNTHESIS; BLOOD; CELL CULTURE; COMPARATIVE STUDY; CYTOLOGY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD1; AUTOIMMUNE DISEASES; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNE COMPLEX DISEASES; INFLAMMATION MEDIATORS; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MONOCYTES; RECEPTORS, CELL SURFACE; RECEPTORS, IGG; T-LYMPHOCYTE SUBSETS;

EID: 70149113045     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0801683     Document Type: Article

References (28)

1. Lorenz, H. M., M. Herrmann, and J. R. Kalden. 2001. The pathogenesis of autoimmune diseases. Scand. J. Clin. Lab Invest. Suppl. 235: 16-26.
2. Schifferli, J. A., and R. P. Taylor. 1989. Physiological and pathological aspects of circulating immune complexes. Kidney Int. 35: 993-1003. (Pubitemid 19099713)
3. Schmidt, R. E., and J. E. Gessner. 2005. Fc receptors and their interaction with complement in autoimmunity. Immunol. Lett. 100: 56-67.
4. Ravetch, J. V., and S. Bolland. 2001. IgG Fc receptors. Annu. Rev. Immunol. 19: 275-290.
5. Berger, S., H. Ballo, and H. J. Stutte. 1996. Immune complex-induced interleukin-6, interleukin-10 and prostaglandin secretion by human monocytes: a network of pro- and anti-inflammatory cytokines dependent on the antigen:antibody ratio. Eur. J. Immunol. 26: 1297-1301.
6. Marsh, C. B., J. E. Gadek, G. C. Kindt, S. A. Moore, and M. D. Wewers. 1995. Monocyte Fcγ receptor cross-linking induces IL-8 production. J. Immunol. 155: 3161-3167.
7. Debets, J. M., J. G. Van de Winkel, J. L. Ceuppens, I. E. Dieteren, and W. A. Buurman. 1990. Cross-linking of both FcγRI and FcγRII induces secretion of tumor necrosis factor by human monocytes, requiring high-affinity Fc-FcγR interactions: functional activation of FcγRII by treatment with proteases or neuraminidase. J. Immunol. 144: 1304-1310.
8. Krutmann, J., R. Kirnbauer, A. Kock, T. Schwarz, E. Schopf, L. T. May, P. B. Sehgal, and T. A. Luger. 1990. Cross-linking Fc receptors on monocytes triggers IL-6 production: role in anti-CD3-induced T cell activation. J. Immunol. 145: 1337-1342.
9. Herrmann, F., S. De Vos, M. Brach, D. Riedel, A. Lindemann, and R. Mertelsmann. 1992. Secretion of granulocyte-macrophage colony-stimulating factor by human blood monocytes is stimulated by engagement of Fcγ receptors type I by solid-phase immunoglobulins requiring high-affinity Fc-Fcγ receptor type I interactions. Eur. J. Immunol. 22: 1681-1685.
10. Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. J. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18: 767-811.
11. Lanzavecchia, A., and F. Sallusto. 2001. Regulation of T cell immunity by dendritic cells. Cell 106: 263-266.
12. Krutzik, S. R., B. Tan, H. Li, M. T. Ochoa, P. T. Liu, S. E. Sharfstein, T. G. Graeber, P. A. Sieling, Y. J. Liu, T. H. Rea, et al. 2005. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat. Med. 11: 653-660.
13. Sieling, P. A., D. Jullien, M. Dahlem, T. F. Tedder, T. H. Rea, R. L. Modlin, and S. A. Porcelli. 1999. CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. J. Immunol. 162: 1851-1858.
14. Laborde, E. A., S. Vanzulli, M. Beigier-Bompadre, M. A. Isturiz, R. A. Ruggiero, M. G. Fourcade, A. C. Catalan Pellet, S. Sozzani, and M. Vulcano. 2007. Immune complexes inhibit differentiation, maturation, and function of human monocyte-derived dendritic cells. J. Immunol. 179: 673-681.
15. Lee, D. J., P. A. Sieling, M. T. Ochoa, S. R. Krutzik, B. Guo, M. Hernandez, T. H. Rea, G. Cheng, M. Colonna, and R. L. Modlin. 2007. LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J. Immunol. 179: 8128-8136.
16. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
17. Wenink, M. H., W. B. van den Berg, P. L. van Riel, and T. R. Radstake. 2006. Fcγ receptor mediated modulation of dendritic cells as a potential strategy in the battle against rheumatoid arthritis. Neth. J. Med. 64:103-108.
18. Nimmerjahn, F., and J. V. Ravetch. 2008. Fcgamma receptors as regulators of immune responses. Nat. Rev. Immunol. 8: 34-47.
19. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α. J. Exp. Med. 179: 1109-1118. (Pubitemid 24091769)
20. Bell, A. L., M. K. Magill, W. R. McKane, F. Kirk, and A. E. Irvine. 1995. Measurement of colony-stimulating factors in synovial fluid: potential clinical value. Rheumatol. Int. 14: 177-182.
21. Abdelaal, M. A., I. A. Hashim, T. H. Zawawi, S. K. Felimban, E. M. Sobhi, O. Jeje, and G. A. Oni. 2000. Circadian rhythm of granulocyte-macrophage colony-stimulating factor in normal subjects and neutropenic hospitalised patients. Ir. J. Med. Sci. 169: 55-57.
22. Banki, Z., L. Kacani, B. Mullauer, D. Wilflingseder, G. Obermoser, H. Niederegger, H. Schennach, G. M. Sprinzl, N. Sepp, A. Erdei, et al. 2003. Cross-linking of CD32 induces maturation of human monocyte-derived dendritic cells via NF-κB signaling pathway. J. Immunol. 170: 3963-3970.
23. Su, K., H. Yang, X. Li, X. Li, A. W. Gibson, J. M. Cafardi, T. Zhou, J. C. Edberg, and R. P. Kimberly. 2007. Expression profile of FcγRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. J. Immunol. 178: 3272-3280.
24. Beckman, E. M., A. Melian, S. M. Behar, P. A. Sieling, D. Chatterjee, S. T. Furlong, R. Matsumoto, J. P. Rosat, R. L. Modlin, and S. A. Porcelli. 1996. CD1c restricts responses of mycobacteria-specific T cells: evidence for antigen presentation by a second member of the human CD1 family. J. Immunol. 157: 2795-2803.
25. Kim, J., A. Sette, S. Rodda, S. Southwood, P. A. Sieling, V. Mehra, J. D. Ohmen, J. L. Oliveros, E. Appella, Y. Higashimoto, et al. 1997. Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue. J. Immunol. 159: 335-343.
26. Hertz, C. J., S. M. Kiertscher, P. J. Godowski, D. A. Bouis, M. V. Norgard, M. D. Roth, and R. L. Modlin. 2000. Microbial lipopeptides stimulate dendritic cell maturation via TLR2. J. Immunol. 166: 2444-2450.
27. + T cells: B7-independent costimulation of CD1-restricted T cells. J. Exp. Med. 182: 2007-2018.
28. Sieling, P. A., D. Chatterjee, S. A. Porcelli, T. I. Prigozy, T. Soriano, M. B. Brenner, M. Kronenberg, P. J. Brennan, and R. L. Modlin. 1995. CD1-restricted T cell recognition of microbial lipoglycans. Science 269: 227-230.