메뉴 건너뛰기




Volumn 10, Issue 1-2, 2009, Pages 16-32

Chronic lymphocytic leukemia: New concepts and emerging therapies

Author keywords

[No Author keywords available]

Indexed keywords

ABT 263; ALEMTUZUMAB; ALKYLATING AGENT; ALLOPURINOL; ANTINEOPLASTIC AGENT; BENDAMUSTINE; BETA 2 MICROGLOBULIN; CD23 ANTIGEN; CD38 ANTIGEN; CHLORAMBUCIL; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLAVOPIRIDOL; FLUDARABINE; LENALIDOMIDE; LUMILIXIMAB; MITOXANTRONE; OBLIMERSEN; OFATUMUMAB; PENTOSTATIN; PREDNISOLONE; PROTEIN KINASE ZAP 70; RITUXIMAB; THYMIDINE KINASE; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 70149110428     PISSN: 15272729     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11864-008-0079-8     Document Type: Review
Times cited : (6)

References (99)
  • 1
    • 33645526144 scopus 로고    scopus 로고
    • Cancer statistics, 2006
    • Jemal, A., et al., 2006. Cancer statistics, 2006. CA Cancer J Clin, 56(2):106-130.
    • (2006) CA Cancer J Clin , vol.56 , Issue.2 , pp. 106-130
    • Jemal, A.1
  • 2
    • 0014071839 scopus 로고
    • Chronic lymphocytic leukemia-an accumulative disease of immunolgically incompetent lymphocytes
    • Dameshek, W., 1967. Chronic lymphocytic leukemia-an accumulative disease of immunolgically incompetent lymphocytes. Blood, 29(Suppl 4):566-584.
    • (1967) Blood , vol.29 , Issue.SUPPL. 4 , pp. 566-584
    • Dameshek, W.1
  • 3
    • 20044372326 scopus 로고    scopus 로고
    • In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
    • Messmer, B.T., et al. 2005 In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 115(3):755-764.
    • (2005) J Clin Invest , vol.115 , Issue.3 , pp. 755-764
    • Messmer, B.T.1
  • 4
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • doi: 10.1172/JCI3009
    • Fais, F., et al. 1998 Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 102(8):1515-25. doi: 10.1172/JCI3009
    • (1998) J Clin Invest , vol.102 , Issue.8 , pp. 1515-1525
    • Fais, F.1
  • 5
    • 0036624881 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
    • doi: 10.1182/blood.V99.11.4087
    • Damle, R.N., et al. 2002 B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood. 99(11):4087-93. doi: 10.1182/blood.V99.11.4087
    • (2002) Blood , vol.99 , Issue.11 , pp. 4087-4093
    • Damle, R.N.1
  • 6
    • 2942584865 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Revelations from the B-cell receptor
    • doi: 10.1182/blood-2003-12-4312
    • Stevenson, F.K. and F. Caligaris-Cappio (2004) Chronic lymphocytic leukemia: Revelations from the B-cell receptor. Blood 103(12):4389-95. doi: 10.1182/blood-2003-12-4312
    • (2004) Blood , vol.103 , Issue.12 , pp. 4389-4395
    • Stevenson, F.K.1    Caligaris-Cappio, F.2
  • 7
    • 0000634555 scopus 로고
    • Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia
    • doi: 10.1073/pnas.86.15.5913
    • Kipps, T.J., et al. 1989 Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 86(15):5913-7. doi: 10.1073/pnas.86.15.5913
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.15 , pp. 5913-5917
    • Kipps, T.J.1
  • 8
    • 33846108722 scopus 로고    scopus 로고
    • 2007 Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations
    • doi: 10.1182/blood-2006-03-012948
    • Stamatopoulos, K., et al. 2007 Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations. Blood 109(1):259-70. doi: 10.1182/blood-2006-03-012948
    • (2007) Blood , vol.109 , Issue.1 , pp. 259-270
    • Stamatopoulos, K.1
  • 9
    • 38949203770 scopus 로고    scopus 로고
    • Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: Implications for the role of antigen selection in leukemogenesis
    • doi: 10.1182/blood-2007-07-099564
    • Murray, F., et al. 2008 Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: Implications for the role of antigen selection in leukemogenesis. Blood 111(3):1524-33. doi: 10.1182/blood-2007-07-099564
    • (2008) Blood , vol.111 , Issue.3 , pp. 1524-1533
    • Murray, F.1
  • 10
    • 0021991920 scopus 로고
    • Human B cell development II Subpopulations in the human fetus
    • Bofill, M., et al. 1985 Human B cell development II Subpopulations in the human fetus. J Immunol 134(3):1531-8.
    • (1985) J Immunol , vol.134 , Issue.3 , pp. 1531-1538
    • Bofill, M.1
  • 11
    • 0022931319 scopus 로고
    • Phenotypic and functional characterization of human Leu1 (CD5) B cells
    • doi: 10.1111/j.1600-065X.1986.tb01500.x
    • Gadol, N. and K.A. Ault 1986 Phenotypic and functional characterization of human Leu1 (CD5) B cells. Immunol Rev 93:23-34. doi: 10.1111/ j.1600-065X.1986.tb01500.x
    • (1986) Immunol Rev , vol.93 , pp. 23-34
    • Gadol, N.1    Ault, K.A.2
  • 12
    • 0035353212 scopus 로고    scopus 로고
    • Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
    • doi: 10.1182/blood.V97.9.2777
    • Granziero, L., et al. 2001 Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 97(9):2777-83. doi: 10.1182/blood.V97.9.2777
    • (2001) Blood , vol.97 , Issue.9 , pp. 2777-2783
    • Granziero, L.1
  • 13
    • 30744467923 scopus 로고    scopus 로고
    • The proliferation center microenvironment and prognostic markers in chronic lymphocytic leukemia/small lymphocytic lymphoma
    • doi: 10.1016/j.humpath.2005.09.029
    • Soma, L.A., F.E. Craig, and S.H. Swerdlow 2006 The proliferation center microenvironment and prognostic markers in chronic lymphocytic leukemia/ small lymphocytic lymphoma. Hum Pathol 37(2):152-9. doi: 10.1016/ j.humpath.2005.09.029
    • (2006) Hum Pathol , vol.37 , Issue.2 , pp. 152-159
    • Soma, L.A.1    Craig, F.E.2    Swerdlow, S.H.3
  • 14
    • 0021880765 scopus 로고
    • A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia
    • doi: 10.1002/art.1780280903
    • Plater-Zyberk, C., et al. 1985 A rheumatoid arthritis B cell subset expresses a phenotype similar to that in chronic lymphocytic leukemia. Arthritis Rheum 28(9):971-6.doi: 10.1002/art.1780280903
    • (1985) Arthritis Rheum , vol.28 , Issue.9 , pp. 971-976
    • Plater-Zyberk, C.1
  • 15
    • 0019504619 scopus 로고
    • Abnormal T-cell subpopulation function in CLL: Excessive suppressor (T gamma) and deficient helper (T mu) activity with respect to B-cell proliferation
    • Kay, N.E. 1981 Abnormal T-cell subpopulation function in CLL: Excessive suppressor (T gamma) and deficient helper (T mu) activity with respect to B-cell proliferation. Blood 57(3):418-20.
    • (1981) Blood , vol.57 , Issue.3 , pp. 418-420
    • Kay, N.E.1
  • 16
    • 0019934873 scopus 로고
    • 1982 Abnormal T lymphocyte subpopulations in patients with B cell chronic lymphocytic leukemia: An analysis by monoclonal antibodies
    • Platsoucas, C.D., et al., 1982 Abnormal T lymphocyte subpopulations in patients with B cell chronic lymphocytic leukemia: An analysis by monoclonal antibodies. J Immunol 129(5):2305-12.
    • (1982) J Immunol , vol.129 , Issue.5 , pp. 2305-2312
    • Platsoucas, C.D.1
  • 17
    • 33645991529 scopus 로고    scopus 로고
    • Risk stratification in chronic lymphocytic leukemia
    • doi: 10.1053/j.seminoncol.2006.01.017
    • Seiler, T., H. Dohner, and S. Stilgenbauer 2006 Risk stratification in chronic lymphocytic leukemia. Semin Oncol. 33(2):186-94. doi: 10.1053/ j.seminoncol.2006.01.017
    • (2006) Semin Oncol. , vol.33 , Issue.2 , pp. 186-194
    • Seiler, T.1    Dohner, H.2    Stilgenbauer, S.3
  • 18
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • doi: 10.1056/NEJM200012283432602
    • Dohner, H., et al., 2000 Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343(26):1910-6. doi: 10.1056/ NEJM200012283432602
    • (2000) N Engl J Med , vol.343 , Issue.26 , pp. 1910-1916
    • Dohner, H.1
  • 19
    • 15244342190 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Novel prognostic factors and their relevance for risk-adapted therapeutic strategies
    • Montillo, M., et al., 2005 Chronic lymphocytic leukemia: Novel prognostic factors and their relevance for risk-adapted therapeutic strategies. Haematologica. 90(3):391-9.
    • (2005) Haematologica , vol.90 , Issue.3 , pp. 391-399
    • Montillo, M.1
  • 20
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin, T.J., et al., 1999 Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94(6):1848-54.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1
  • 21
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle, R.N., et al., 1999 Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 94(6):1840-7.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1840-1847
    • Damle, R.N.1
  • 22
    • 23844444499 scopus 로고    scopus 로고
    • Prognostic usage of V(H) gene mutation status and its surrogate markers and the role of antigen selection in chronic lymphocytic leukemia
    • doi: 10.1385/MO:22:3:217
    • Tobin, G. and R. Rosenquist 2005 Prognostic usage of V(H) gene mutation status and its surrogate markers and the role of antigen selection in chronic lymphocytic leukemia. Med Oncol 22(3):217-28. doi: 10.1385/ MO:22:3:217
    • (2005) Med Oncol , vol.22 , Issue.3 , pp. 217-228
    • Tobin, G.1    Rosenquist, R.2
  • 23
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • doi: 10.1056/NEJMoa040857
    • Rassenti, L.Z., et al., 2004 ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 351(9):893-901. doi: 10.1056/NEJMoa040857
    • (2004) N Engl J Med , vol.351 , Issue.9 , pp. 893-901
    • Rassenti, L.Z.1
  • 24
    • 33746589459 scopus 로고    scopus 로고
    • Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia
    • doi: 10.1182/blood-2005-12-4986
    • Del Principe, M.I., et al., 2006 Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia. Blood 108(3):853-61. doi: 10.1182/blood-2005-12-4986
    • (2006) Blood , vol.108 , Issue.3 , pp. 853-861
    • Del Principe, M.I.1
  • 25
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • doi: 10.1084/jem.194.11.1639
    • Rosenwald, A., et al., 2001 Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 194(11):1639-47. doi: 10.1084/jem.194.11.1639
    • (2001) J Exp Med , vol.194 , Issue.11 , pp. 1639-1647
    • Rosenwald, A.1
  • 26
    • 0033106396 scopus 로고    scopus 로고
    • Elevated Serum Thymidine Kinase Levels Identify a Subgroup at High Risk of Disease Progression in Early, Nonsmoldering Chronic Lymphocytic Leukemia
    • Hallek, M., et al., 1999 Elevated Serum Thymidine Kinase Levels Identify a Subgroup at High Risk of Disease Progression in Early, Nonsmoldering Chronic Lymphocytic Leukemia. Blood 93(5):1732-1737.
    • (1999) Blood , vol.93 , Issue.5 , pp. 1732-1737
    • Hallek, M.1
  • 27
    • 0030324331 scopus 로고    scopus 로고
    • Cellular expression and serum circulating levels of CD23 in B-cell chronic lymphocytic leukemia Implications for prognosis
    • Molica, S., et al., 1996 Cellular expression and serum circulating levels of CD23 in B-cell chronic lymphocytic leukemia Implications for prognosis. Haematologica 81(5):428-33.
    • (1996) Haematologica , vol.81 , Issue.5 , pp. 428-433
    • Molica, S.1
  • 28
    • 0029829395 scopus 로고    scopus 로고
    • Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma
    • doi: 10.3109/10428199609054782
    • Hallek, M., et al., 1996 Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma. Leuk Lymphoma 22(5-6):439-47. doi: 10.3109/10428199609054782
    • (1996) Leuk Lymphoma , vol.22 , Issue.5-6 , pp. 439-447
    • Hallek, M.1
  • 29
    • 0032911377 scopus 로고    scopus 로고
    • Clinico-prognostic implications of simultaneous increased serum levels of soluble CD23 and beta2-microglobulin in B-cell chronic lymphocytic leukemia
    • Molica, S., et al., 1999 Clinico-prognostic implications of simultaneous increased serum levels of soluble CD23 and beta2-microglobulin in B-cell chronic lymphocytic leukemia. Eur J Haematol. 62(2):117-22.
    • (1999) Eur J Haematol , vol.62 , Issue.2 , pp. 117-122
    • Molica, S.1
  • 30
    • 51649093353 scopus 로고    scopus 로고
    • Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia
    • doi: 10.1182/blood-2008-02-140582
    • Tam, C.S., et al., 2008 Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia. Blood 112(4):975-80. doi: 10.1182/ blood-2008-02-140582
    • (2008) Blood , vol.112 , Issue.4 , pp. 975-980
    • Tam, C.S.1
  • 31
    • 38549168905 scopus 로고    scopus 로고
    • Comorbid conditions and survival in unselected, newly diagnosed patients with chronic lymphocytic leukemia
    • doi: 10.1080/10428190701724785
    • Thurmes, P., et al., 2008 Comorbid conditions and survival in unselected, newly diagnosed patients with chronic lymphocytic leukemia. Leuk Lymphoma 49(1):49-56. doi: 10.1080/10428190701724785
    • (2008) Leuk Lymphoma , vol.49 , Issue.1 , pp. 49-56
    • Thurmes, P.1
  • 32
    • 0035136382 scopus 로고    scopus 로고
    • What is changing in the natural history of chronic lymphocytic leukemia?
    • Molica, S. and D. Levato 2001 What is changing in the natural history of chronic lymphocytic leukemia? Haematologica 86(1):8-12.
    • (2001) Haematologica , vol.86 , Issue.1 , pp. 8-12
    • Molica, S.1    Levato, D.2
  • 33
    • 0033583824 scopus 로고    scopus 로고
    • Chemotherapeutic options in chronic lymphocytic leukemia: A meta-analysis of the randomized trials 1999 CLL Trialists' Collaborative Group
    • doi: 10.1093/jnci/91.10.861
    • Chemotherapeutic options in chronic lymphocytic leukemia: A meta-analysis of the randomized trials 1999 CLL Trialists' Collaborative Group. J Natl Cancer Inst 91(10):861-8. doi: 10.1093/jnci/91.10.861
    • (1999) J Natl Cancer Inst , vol.91 , Issue.10 , pp. 861-868
  • 34
    • 0023717101 scopus 로고
    • Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the National Cancer Institute-sponsored working group
    • doi: 10.1002/ajh.2830290307
    • Cheson, B.D., et al., 1988 Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the National Cancer Institute-sponsored working group. Am J Hematol 29(3):152-63. doi: 10.1002/ajh.2830290307
    • (1988) Am J Hematol , vol.29 , Issue.3 , pp. 152-163
    • Cheson, B.D.1
  • 35
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson, B.D., et al., 1996 National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment. Blood 87(12):4990-7.
    • (1996) Blood , vol.87 , Issue.12 , pp. 4990-4997
    • Cheson, B.D.1
  • 36
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek, M., et al., 2008 Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111(12):5446-56.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1
  • 37
    • 0842285686 scopus 로고    scopus 로고
    • Prognosis at diagnosis: Integrating molecular biologic insights into clinical practice for patients with CLL
    • doi: 10.1182/blood-2003-07-2281
    • Shanafelt, T.D., S.M. Geyer, and N.E. Kay, 2004 Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL. Blood 103(4):1202-10. doi: 10.1182/blood-2003-07-2281
    • (2004) Blood , vol.103 , Issue.4 , pp. 1202-1210
    • Shanafelt, T.D.1    Geyer, S.M.2    Kay, N.E.3
  • 38
    • 27144470672 scopus 로고    scopus 로고
    • Elevated thymidine kinase and short lymphocyte doubling time in combination with unfavourable cytogenetics or unmutated IgVH status are strong predictors for high individual risk for rapid disease progression in patients with B-CLL in Binet stage A: An interim report from the CLL1 protocol of the German CLL Study Group (GCLLSG)
    • Abstr 2464
    • Bergmann M, Busch R, Hallek M: Elevated thymidine kinase and short lymphocyte doubling time in combination with unfavourable cytogenetics or unmutated IgVH status are strong predictors for high individual risk for rapid disease progression in patients with B-CLL in Binet stage A: an interim report from the CLL1 protocol of the German CLL Study Group (GCLLSG). Blood 102: Abstr 2464
    • Blood , vol.102
    • Bergmann, M.1    Busch, R.2    Hallek, M.3
  • 39
    • 15844368449 scopus 로고    scopus 로고
    • Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia The French Cooperative Group on CLL
    • Johnson, S., et al. 1996 Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia The French Cooperative Group on CLL. Lancet 347(9013):1432-8.
    • (1996) Lancet , vol.347 , Issue.9013 , pp. 1432-1438
    • Johnson, S.1
  • 40
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • doi: 10.1056/NEJM200012143432402
    • Rai, K.R., et al., 2000 Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 343(24):1750-7. doi: 10.1056/NEJM200012143432402
    • (2000) N Engl J Med , vol.343 , Issue.24 , pp. 1750-1757
    • Rai, K.R.1
  • 41
    • 0035889147 scopus 로고    scopus 로고
    • Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
    • doi: 10.1182/blood.V98.8.2319
    • Leporrier, M., et al., 2001 Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients. Blood 98(8):2319-25. doi: 10.1182/blood.V98.8.2319
    • (2001) Blood , vol.98 , Issue.8 , pp. 2319-2325
    • Leporrier, M.1
  • 42
    • 31544434508 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
    • doi: 10.1182/blood-2005-06-2395
    • Eichhorst, B.F., et al., 2006 Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood 107(3):885-91. doi: 10.1182/ blood-2005-06-2395
    • (2006) Blood , vol.107 , Issue.3 , pp. 885-891
    • Eichhorst, B.F.1
  • 43
    • 33947541773 scopus 로고    scopus 로고
    • Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997
    • doi: 10.1200/JCO.2006.08.0762
    • Flinn, I.W., et al., 2007 Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol 25(7):793-8. doi: 10.1200/JCO.2006.08.0762
    • (2007) J Clin Oncol , vol.25 , Issue.7 , pp. 793-798
    • Flinn, I.W.1
  • 44
    • 33947544426 scopus 로고    scopus 로고
    • Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: Results from the US Intergroup Phase III Trial E2997
    • doi: 10.1200/JCO.2006.08.3089
    • Grever, M.R., et al., 2007 Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: Results from the US Intergroup Phase III Trial E2997. J Clin Oncol 25(7):799-804. doi: 10.1200/JCO.2006.08.3089
    • (2007) J Clin Oncol , vol.25 , Issue.7 , pp. 799-804
    • Grever, M.R.1
  • 45
    • 41149097613 scopus 로고    scopus 로고
    • Bendamustine Versus Chlorambucil in Treatment-Naive Patients with B-Cell Chronic Lymphocytic Leukemia (B-CLL): Results of an International Phase III Study
    • Knauf, W.U., et al., 2007 Bendamustine Versus Chlorambucil in Treatment-Naive Patients with B-Cell Chronic Lymphocytic Leukemia (B-CLL): Results of an International Phase III Study. ASH Annual Meeting Abstracts 110(11):2043
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 2043
    • Knauf, W.U.1
  • 46
    • 0025348259 scopus 로고
    • The CAMPATH-1 antigen (CDw52)
    • doi: 10.1111/j.1399-0039.1990.tb01767.x
    • Hale, G., et al. 1990 The CAMPATH-1 antigen (CDw52). Tissue Antigens 35(3):118-27. doi: 10.1111/j.1399-0039.1990.tb01767.x
    • (1990) Tissue Antigens , vol.35 , Issue.3 , pp. 118-127
    • Hale, G.1
  • 47
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • doi: 10.1182/blood.V99.10.3554
    • Keating, M.J., et al. 2002 Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study. Blood 99 (10):3554-61. doi: 10.1182/ blood.V99.10.3554
    • (2002) Blood , vol.99 , Issue.10 , pp. 3554-3561
    • Keating, M.J.1
  • 48
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • doi: 10.1182/blood-2002-01-0159
    • Lundin, J., et al. 2002 Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 100(3):768-73. doi: 10.1182/blood-2002-01-0159
    • (2002) Blood , vol.100 , Issue.3 , pp. 768-773
    • Lundin, J.1
  • 49
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2007.12.9098
    • Hillmen, P., et al. 2007 Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 25(35):5616-23. doi: 10.1200/JCO.2007.12.9098
    • (2007) J Clin Oncol , vol.25 , Issue.35 , pp. 5616-5623
    • Hillmen, P.1
  • 50
    • 37649012732 scopus 로고    scopus 로고
    • Have we forgotten the purpose of phase III studies?
    • doi: 10.1200/JCO.2007.13.7810
    • Flynn, J.M. and J.C. Byrd 2007 Have we forgotten the purpose of phase III studies? J Clin Oncol 25(35):5553-5. doi: 10.1200/JCO.2007.13.7810
    • (2007) J Clin Oncol , vol.25 , Issue.35 , pp. 5553-5555
    • Flynn, J.M.1    Byrd, J.C.2
  • 51
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
    • McLaughlin, P., et al. 1998 Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program. J Clin Oncol 16(8):2825-33.
    • (1998) J Clin Oncol , vol.16 , Issue.8 , pp. 2825-2833
    • McLaughlin, P.1
  • 52
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • doi: 10.1182/blood.V98.5.1326
    • Huhn, D., et al. 2001 Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood 98(5):1326-31. doi: 10.1182/blood.V98.5.1326
    • (2001) Blood , vol.98 , Issue.5 , pp. 1326-1331
    • Huhn, D.1
  • 53
    • 0038446696 scopus 로고    scopus 로고
    • Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance
    • doi: 10.1182/blood-2002-06-1639
    • Manshouri, T., et al. 2003 Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance. Blood 101(7):2507-13. doi: 10.1182/blood-2002-06-1639
    • (2003) Blood , vol.101 , Issue.7 , pp. 2507-2513
    • Manshouri, T.1
  • 54
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd, J.C., et al. 2001 Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 19(8):2153-64.
    • (2001) J Clin Oncol , vol.19 , Issue.8 , pp. 2153-2164
    • Byrd, J.C.1
  • 55
    • 0035871441 scopus 로고    scopus 로고
    • Rituximab dose-escalation trial in chronic lymphocytic leukemia
    • O'Brien, S.M., et al. 2001 Rituximab dose-escalation trial in chronic lymphocytic leukemia. J Clin Oncol 19(8):2165-70.
    • (2001) J Clin Oncol , vol.19 , Issue.8 , pp. 2165-2170
    • O'Brien, S.M.1
  • 56
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • doi: 10.1182/blood-2002-04-1258
    • Byrd, J.C., et al. 2003 Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 101(1):6-14. doi: 10.1182/blood-2002-04-1258
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1
  • 57
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2005.12.051
    • Keating, M.J., et al. 2005 Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol 23(18):4079-88. doi: 10.1200/ JCO.2005.12.051
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4079-4088
    • Keating, M.J.1
  • 58
    • 33846258434 scopus 로고    scopus 로고
    • Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
    • doi: 10.1182/blood-2006-07-033274
    • Kay, N.E., et al. 2007 Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia. Blood 109 (2):405-11. doi: 10.1182/blood-2006-07-033274
    • (2007) Blood , vol.109 , Issue.2 , pp. 405-411
    • Kay, N.E.1
  • 59
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • doi: 10.1182/blood-2004-03-0796
    • Byrd, J.C., et al 2005, Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 105(1):49-53. doi: 10.1182/blood-2004-03-0796
    • (2005) Blood , vol.105 , Issue.1 , pp. 49-53
    • Byrd, J.C.1
  • 60
    • 45149110164 scopus 로고    scopus 로고
    • Combined Cyclophosphamide, Fludarabine, Alemtuzumab, and Rituximab (CFAR), an Active Frontline Regimen for High-Risk Patients with CLL
    • Wierda, W.G., et al. 2007 Combined Cyclophosphamide, Fludarabine, Alemtuzumab, and Rituximab (CFAR), an Active Frontline Regimen for High-Risk Patients with CLL. ASH Annual Meeting Abstracts 110(11):628
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 628
    • Wierda, W.G.1
  • 61
    • 34247594390 scopus 로고    scopus 로고
    • International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia
    • Rawstron, A.C., et al. 2007 International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia 21(5):956-64.
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 956-964
    • Rawstron, A.C.1
  • 62
    • 21144456107 scopus 로고    scopus 로고
    • Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival
    • doi: 10.1200/JCO.2005.04.021
    • Moreton, P., et al. 2005 Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival. J Clin Oncol 23(13):2971-9. doi: 10.1200/JCO.2005.04.021
    • (2005) J Clin Oncol , vol.23 , Issue.13 , pp. 2971-2979
    • Moreton, P.1
  • 63
    • 2942694373 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
    • doi: 10.1038/sj.leu.2403354
    • Wendtner, C.M., et al. 2004 Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG). Leukemia 18 (6):1093-101. doi: 10.1038/sj.leu.2403354
    • (2004) Leukemia , vol.18 , Issue.6 , pp. 1093-1101
    • Wendtner, C.M.1
  • 64
    • 33845980558 scopus 로고    scopus 로고
    • Minimal residual disease in chronic lymphocytic leukaemia: Is it ready for primetime?
    • doi: 10.1111/j.1365-2141.2006.06428.x
    • Nabhan, C., S. Coutre, and P. Hillmen 2007 Minimal residual disease in chronic lymphocytic leukaemia: Is it ready for primetime? Br J Haematol 136(3):379-92. doi: 10.1111/j.1365-2141.2006.06428.x
    • (2007) Br J Haematol , vol.136 , Issue.3 , pp. 379-392
    • Nabhan, C.1    Coutre, S.2    Hillmen, P.3
  • 65
    • 0344236261 scopus 로고    scopus 로고
    • Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia
    • doi: 10.1002/cncr.11871
    • O'Brien, S.M., et al. 2003 Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia. Cancer 98 (12):2657-63. doi: 10.1002/cncr.11871
    • (2003) Cancer , vol.98 , Issue.12 , pp. 2657-2663
    • O'Brien, S.M.1
  • 66
    • 51249108295 scopus 로고    scopus 로고
    • Consolidation therapy with subcutaneous (SC) alemtuzumab results in severe infectious toxicity in previously untreated CLL patients who achieve a complete response (CR) after fludarabine and rituximab (FR) induction therapy: Interim safety analysis of the CALGB study 10101
    • Lin TS, et al.: Consolidation therapy with subcutaneous (SC) alemtuzumab results in severe infectious toxicity in previously untreated CLL patients who achieve a complete response (CR) after fludarabine and rituximab (FR) induction therapy: Interim safety analysis of the CALGB study 10101. ASH Annl Meet Abstr 110(11):755
    • ASH Annl Meet Abstr , vol.110 , Issue.11 , pp. 755
    • Lin, T.S.1
  • 67
    • 0032529509 scopus 로고    scopus 로고
    • Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy
    • Keating, M.J., et al. 1998 Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy. Blood 92(4):1165-71.
    • (1998) Blood , vol.92 , Issue.4 , pp. 1165-1171
    • Keating, M.J.1
  • 68
    • 0036335916 scopus 로고    scopus 로고
    • Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia
    • doi: 10.1080/1042819021000006547
    • Keating, M.J., et al. 2002 Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia. Leuk Lymphoma. 43(9):1755-62. doi: 10.1080/1042819021000006547
    • (2002) Leuk Lymphoma , vol.43 , Issue.9 , pp. 1755-1762
    • Keating, M.J.1
  • 69
    • 0030007085 scopus 로고    scopus 로고
    • Fludarabine in resistant or relapsing B-cell chronic lymphocytic leukemia: The Spanish Group experience
    • doi: 10.3109/10428199609093445
    • Montserrat, E., et al. 1996 Fludarabine in resistant or relapsing B-cell chronic lymphocytic leukemia: The Spanish Group experience. Leuk Lymphoma 21 (5-6):467-72. doi: 10.3109/10428199609093445
    • (1996) Leuk Lymphoma , vol.21 , Issue.5-6
    • Montserrat, E.1
  • 70
    • 0035282055 scopus 로고    scopus 로고
    • Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia
    • O'Brien, S.M., et al. 2001 Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia. J Clin Oncol 19(5):1414-20.
    • (2001) J Clin Oncol , vol.19 , Issue.5 , pp. 14141-14220
    • O'Brien, S.M.1
  • 71
    • 23044501404 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2005.12.516
    • Wierda, W., et al. 2005 Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J Clin Oncol 23(18):4070-8. doi: 10.1200/ JCO.2005.12.516
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4070-4078
    • Wierda, W.1
  • 72
    • 18744409028 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukaemia
    • doi: 10.1046/j.1365-2141.2002.03959.x
    • Bosch, F., et al. 2002 Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukaemia. Br J Haematol 119(4):976-84. doi: 10.1046/j.1365-2141.2002.03959.x
    • (2002) Br J Haematol , vol.119 , Issue.4 , pp. 976-984
    • Bosch, F.1
  • 73
    • 1842450530 scopus 로고    scopus 로고
    • Fludarabine, cyclophosphamide and mitoxantrone in relapsed or refractory chronic lymphocytic leukemia and low grade non-Hodgkin's lymphoma
    • doi: 10.1080/10428190310001639489
    • Hendry, L., et al. 2004 Fludarabine, cyclophosphamide and mitoxantrone in relapsed or refractory chronic lymphocytic leukemia and low grade non-Hodgkin's lymphoma. Leuk Lymphoma 45(5):945-50. doi: 10.1080/ 10428190310001639489
    • (2004) Leuk Lymphoma , vol.45 , Issue.5 , pp. 945-950
    • Hendry, L.1
  • 74
    • 0038514130 scopus 로고    scopus 로고
    • Pentostatin and cyclophosphamide: An effective new regimen in previously treated patients with chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2003.08.100
    • Weiss, M.A., et al. 2003 Pentostatin and cyclophosphamide: An effective new regimen in previously treated patients with chronic lymphocytic leukemia. J Clin Oncol 21(7):1278-84. doi: 10.1200/JCO.2003.08.100
    • (2003) J Clin Oncol , vol.21 , Issue.7 , pp. 1278-1284
    • Weiss, M.A.1
  • 75
    • 33645732715 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2005.04.3836
    • Lamanna N, et al.: Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia. J Clin Oncol 24(10):1575-1581. doi: 10.1200/JCO.2005.04.3836
    • J Clin Oncol , vol.24 , Issue.10 , pp. 1575-1581
    • Lamanna, N.1
  • 76
    • 27244451794 scopus 로고    scopus 로고
    • Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: Results of a phase II trial
    • doi: 10.1200/JCO.2005.01.9950
    • Elter, T., et al. 2005 Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: Results of a phase II trial. J Clin Oncol 23(28):7024-31. doi: 10.1200/JCO.2005.01.9950
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 7024-7031
    • Elter, T.1
  • 77
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies
    • doi: 10.1182/blood-2002-07-1952
    • Faderl, S., et al. 2003 Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood 101(9):3413-5. doi: 10.1182/blood-2002-07-1952
    • (2003) Blood , vol.101 , Issue.9 , pp. 3413-3415
    • Faderl, S.1
  • 78
    • 70149083143 scopus 로고    scopus 로고
    • Combined Fludarabine, Cyclophosphamide, and Alemtuzumab (FCC), an Active Regimen for Treated Patients with Chronic Lymphocytic Leukemia (CLL)
    • Montillo, M., et al. 2007 Combined Fludarabine, Cyclophosphamide, and Alemtuzumab (FCC), an Active Regimen for Treated Patients with Chronic Lymphocytic Leukemia (CLL). ASH Annual Meeting Abstracts 110(11):3133
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 3133
    • Montillo, M.1
  • 79
    • 27144548424 scopus 로고    scopus 로고
    • Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase I/II study of the German CLL Study Group
    • Bergmann, M.A., et al. 2005 Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase I/II study of the German CLL Study Group. Haematologica 90(10):1357-64.
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1357-1364
    • Bergmann, M.A.1
  • 80
    • 41149143668 scopus 로고    scopus 로고
    • Bendamustine in Combination with Rituximab (BR) for Patients with Relapsed Chronic Lymphocytic Leukemia (CLL): A Multicentre Phase II Trial of the German CLL Study Group (GCLLSG)
    • Fischer, K., et al. 2007 Bendamustine in Combination with Rituximab (BR) for Patients with Relapsed Chronic Lymphocytic Leukemia (CLL): A Multicentre Phase II Trial of the German CLL Study Group (GCLLSG). ASH Annual Meeting Abstracts 110(11):3106
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 3106
    • Fischer, K.1
  • 81
    • 4444227593 scopus 로고    scopus 로고
    • Stem cell transplantation for chronic lymphocytic leukemia: Should not more patients get a transplant?
    • doi: 10.1038/sj.bmt.1704593
    • Jabbour, E., et al. 2004 Stem cell transplantation for chronic lymphocytic leukemia: Should not more patients get a transplant? Bone Marrow Transplant 34(4):289-97. doi: 10.1038/sj.bmt.1704593
    • (2004) Bone Marrow Transplant , vol.34 , Issue.4 , pp. 289-297
    • Jabbour, E.1
  • 82
    • 0036839595 scopus 로고    scopus 로고
    • The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation
    • doi: 10.1182/blood-2002-02-0506
    • Marks, D.I., et al. 2002 The toxicity and efficacy of donor lymphocyte infusions given after reduced-intensity conditioning allogeneic stem cell transplantation. Blood 100(9):3108-14. doi: 10.1182/ blood-2002-02-0506
    • (2002) Blood , vol.100 , Issue.9 , pp. 3108-3114
    • Marks, D.I.1
  • 83
    • 38049141530 scopus 로고    scopus 로고
    • Outcomes after allogeneic hematopoietic cell transplantation with nonmyeloablative or myeloablative conditioning regimens for treatment of lymphoma and chronic lymphocytic leukemia
    • doi: 10.1182/blood-2007-07-098483
    • Sorror, M.L., et al. 2008 Outcomes after allogeneic hematopoietic cell transplantation with nonmyeloablative or myeloablative conditioning regimens for treatment of lymphoma and chronic lymphocytic leukemia. Blood 111(1):446-52. doi: 10.1182/blood-2007-07-098483
    • (2008) Blood , vol.111 , Issue.1 , pp. 446-452
    • Sorror, M.L.1
  • 84
    • 27744549869 scopus 로고    scopus 로고
    • Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-)
    • doi: 10.1158/1078-0432.CCR-05-0941
    • Caballero, D., et al. 2005 Allogeneic transplant with reduced intensity conditioning regimens may overcome the poor prognosis of B-cell chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene and chromosomal abnormalities (11q- and 17p-). Clin Cancer Res. 11(21):7757-63. doi: 10.1158/1078-0432.CCR-05-0941
    • (2005) Clin Cancer Res. , vol.11 , Issue.21 , pp. 7757-7763
    • Caballero, D.1
  • 85
    • 54449093967 scopus 로고    scopus 로고
    • Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
    • Sorror ML, et al.: Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol, 2008, 26(30):4912-4920
    • (2008) J Clin Oncol , vol.26 , Issue.30 , pp. 4912-4920
    • Sorror, M.L.1
  • 86
    • 34948866783 scopus 로고    scopus 로고
    • Relapse risk in patients with malignant diseases given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
    • doi: 10.1182/blood-2007-03-078592
    • Kahl, C., et al. 2007 Relapse risk in patients with malignant diseases given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. Blood 110(7):2744-8. doi: 10.1182/ blood-2007-03-078592
    • (2007) Blood , vol.110 , Issue.7 , pp. 2744-2748
    • Kahl, C.1
  • 87
    • 55549097826 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: A retrospective European group for blood and marrow transplantation analysis
    • Schetelig J, et al.: Allogeneic hematopoietic stem-cell transplantation for chronic lymphocytic leukemia with 17p deletion: A retrospective European group for blood and marrow transplantation analysis. J Clin Oncol, 2008, 26(31):5094-5100
    • (2008) J Clin Oncol , vol.26 , Issue.31 , pp. 5094-5100
    • Schetelig, J.1
  • 88
    • 33845543049 scopus 로고    scopus 로고
    • Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus
    • doi: 10.1038/sj.leu.2404441
    • Dreger, P., et al. 2007 Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: The EBMT transplant consensus. Leukemia 21(1):12-7. doi: 10.1038/sj.leu.2404441
    • (2007) Leukemia , vol.21 , Issue.1 , pp. 12-17
    • Dreger, P.1
  • 89
    • 32944475363 scopus 로고    scopus 로고
    • Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2005.02.4364
    • O'Brien, S.M., et al. 2005 Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia. J Clin Oncol 23(30):7697-702. doi: 10.1200/ JCO.2005.02.4364
    • (2005) J Clin Oncol , vol.23 , Issue.30 , pp. 7697-7702
    • O'Brien, S.M.1
  • 90
    • 34047217206 scopus 로고    scopus 로고
    • Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2006.07.1191
    • O'Brien, S., et al. 2007 Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol 25(9):1114-20. doi: 10.1200/JCO.2006.07.1191
    • (2007) J Clin Oncol , vol.25 , Issue.9 , pp. 1114-1120
    • O'Brien, S.1
  • 91
    • 33947243663 scopus 로고    scopus 로고
    • Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study
    • doi: 10.1200/JCO.2005.05.0401
    • Chanan-Khan, A., et al. 2006 Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase II study. J Clin Oncol 24(34):5343-9. doi: 10.1200/ JCO.2005.05.0401
    • (2006) J Clin Oncol , vol.24 , Issue.34 , pp. 5343-5349
    • Chanan-Khan, A.1
  • 92
    • 45949100928 scopus 로고    scopus 로고
    • Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
    • doi: 10.1182/blood-2007-12-130120
    • Ferrajoli, A., et al. 2008 Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 111(11):5291-7. doi: 10.1182/blood-2007-12-130120
    • (2008) Blood , vol.111 , Issue.11 , pp. 5291-5297
    • Ferrajoli, A.1
  • 93
    • 36849068944 scopus 로고    scopus 로고
    • Tumor lysis syndrome/tumor flare reaction in lenalidomide-treated chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2007.14.2141
    • Moutouh-de Parseval LA, et al.: Tumor lysis syndrome/tumor flare reaction in lenalidomide-treated chronic lymphocytic leukemia. J Clin Oncol 2007,25(31):5047. doi: 10.1200/JCO.2007.14.2141
    • (2007) J Clin Oncol , vol.25 , Issue.31 , pp. 5047
    • Moutouh-de Parseval, L.A.1
  • 94
    • 45149115902 scopus 로고    scopus 로고
    • Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia
    • doi: 10.1200/JCO.2007.13.9709
    • Andritsos, L.A., et al. 2008 Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 26(15):2519-25. doi: 10.1200/JCO.2007.13.9709
    • (2008) J Clin Oncol , vol.26 , Issue.15 , pp. 2519-2525
    • Andritsos, L.A.1
  • 95
    • 78650760117 scopus 로고    scopus 로고
    • Lenalidomide: What is the right dose in CLL?
    • doi: 10.1182/blood-2008-03-146878
    • Lin TS: Wenalidomide: what is the right dose in CLL? Blood 2008, 111(11):5268. doi: 10.1182/blood-2008-03-146878
    • (2008) Blood , vol.111 , Issue.11 , pp. 5268
    • Lin, T.S.1
  • 96
    • 33846219417 scopus 로고    scopus 로고
    • Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
    • doi: 10.1182/blood-2006-05-020735
    • Byrd, J.C., et al. 2007 Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 109(2):399-404. doi: 10.1182/blood-2006-05-020735
    • (2007) Blood , vol.109 , Issue.2 , pp. 399-404
    • Byrd, J.C.1
  • 97
    • 38949216227 scopus 로고    scopus 로고
    • Comparison of Results from a Phase 1/2 Study of Lumiliximab (Anti-CD23) in Combination with FCR for Patients with Relapsed CLL with Published FCR Results
    • Byrd, J.C., et al. 2006 Comparison of Results from a Phase 1/2 Study of Lumiliximab (Anti-CD23) in Combination with FCR for Patients with Relapsed CLL with Published FCR Results. ASH Annual Meeting Abstracts 108(11):32
    • (2006) ASH Annual Meeting Abstracts , vol.108 , Issue.11 , pp. 32
    • Byrd, J.C.1
  • 98
    • 38949185742 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study
    • doi: 10.1182/blood-2007-09-111781
    • Coiffier, B., et al. 2008 Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study. Blood 111(3):1094-100. doi: 10.1182/blood-2007-09-111781
    • (2008) Blood , vol.111 , Issue.3 , pp. 1094-1100
    • Coiffier, B.1
  • 99
    • 59349109256 scopus 로고    scopus 로고
    • A phase 1 study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies
    • Wilson WH, et al.: A phase 1 study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies. J Clin Oncol (Meet Abstr) 2008, 26 (15 suppl):8511
    • (2008) J Clin Oncol (Meet Abstr) , vol.26 , Issue.15 SUPPL. , pp. 8511
    • Wilson, W.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.