Differential Regulation of Human PlGF Gene Expression in Trophoblast and Nontrophoblast Cells by Oxygen Tension

Placenta

Volumn 30, Issue 10, 2009, Pages 869-875

  Gobble, R M ^a   Groesch, K A ^a   Chang, M ^a   Torry, R J ^b   Torry, D S ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DRAKE UNIVERSITY   (United States)

Author keywords

Gene expression; Hypoxia; Hypoxia response element; Placenta growth factor; Pregnancy; Trophoblast

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PLACENTAL GROWTH FACTOR;

ARTICLE; CELL STRAIN; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; HYPOXIA; JEG 3 CELL; MOLECULAR CLONING; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TROPHOBLAST;

CELL HYPOXIA; CELL LINE, TUMOR; CELL NUCLEUS; CELLS, CULTURED; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MEMBRANE PROTEINS; OXYGEN; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; RESPONSE ELEMENTS; TRANS-ACTIVATORS; TRANSFECTION; TROPHOBLASTS;

EID: 70149109336     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2009.08.003     Document Type: Article

References (45)

1. Ziche M., Maglione D., Ribatti D., Morbidelli L., Lago C.T., Battisti M., et al. Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic. Lab Invest 76 (1997) 517-531
2. Maglione D., Guerriero V., Viglietto G., Delli-Bovi P., and Persico M.G. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci U S A 88 (1991) 9267-9271
3. Khaliq A., Li X.F., Shams M., Sisi P., Acevedo C.A., Whittle M.J., et al. Localisation of placenta growth factor (PIGF) in human term placenta. Growth Factors 13 (1996) 243-250
4. Clark D.E., Smith S.K., Licence D., Evans A.L., and Charnock-Jones D.S. Comparison of expression patterns for placenta growth factor, vascular endothelial growth factor (VEGF), VEGF-B and VEGF-C in the human placenta throughout gestation. J Endocrinol 159 (1998) 459-467
5. Hanna J., Goldman-Wohl D., Hamani Y., Avraham I., Greenfield C., Natanson-Yaron S., et al. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 12 (2006) 1065-1074
6. Torry D.S., Wang H.S., Wang T.H., Caudle M.R., and Torry R.J. Preeclampsia is associated with reduced serum levels of placenta growth factor. Am J Obstet Gynecol 179 (1998) 1539-1544
7. Livingston J.C., Chin R., Haddad B., McKinney E.T., Ahokas R., and Sibai B.M. Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia. Am J Obstet Gynecol 183 (2000) 1554-1557
8. Tidwell S.C., Ho H.N., Chiu W.H., Torry R.J., and Torry D.S. Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia. Am J Obstet Gynecol 184 (2001) 1267-1272
9. Levine R.J., Maynard S.E., Qian C., Lim K.H., England L.J., Yu K.F., et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350 (2004) 672-683
10. Maynard S.E., Min J.Y., Merchan J., Lim K.H., Li J., Mondal S., et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111 (2003) 649-658
11. Bahtiyar M.O., Buhimschi C., Ravishankar V., Copel J., Norwitz E., Julien S., et al. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. Am J Obstet Gynecol 196 (2007) 72-76
12. Lijnen H.R., Christiaens V., Scroyen I., Voros G., Tjwa M., Carmeliet P., et al. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 55 (2006) 2698-2704
13. Torry R.J., Schwartz J.S., and Torry D.S. Vascularization of the placenta. In: Tomanek R.J. (Ed). Cardiovascular molecular morphogenesis: assembly of the vasculature and its regulation (2002), Springer-Verlag, New York, NY
14. Granger J.P., Alexander B.T., Llinas M.T., Bennett W.A., and Khalil R.A. Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation 9 (2002) 147-160
15. Torry D.S., Hinrichs M., and Torry R.J. Determinants of placental vascularity. Am J Reprod Immunol 51 (2004) 257-268
16. Shore V.H., Wang T.H., Wang C.L., Torry R.J., Caudle M.R., and Torry D.S. Vascular endothelial growth factor, placenta growth factor and their receptors in isolated human trophoblast. Placenta 18 (1997) 657-665
17. Li H., Gu B., Zhang Y., Lewis D.F., and Wang Y. Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta. Placenta 26 (2005) 210-217
18. Gleadle J.M., Ebert B.L., Firth J.D., and Ratcliffe P.J. Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am J Phys 268 (1995) 1362-1368
19. Ahmed A., Dunk C., Ahmad S., and Khaliq A. Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) and soluble Flt-1 by oxygen- a review. Placenta 21 (2000) S16-S24
20. Green C.J., Lichtlen P., Huynh N.T., Yanovsky M., Laderoute K.R., Schaffner W., et al. Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1. Cancer Res 61 (2001) 2696-2703
21. Cramer M., Nagy I., Murphy B.J., Gassmann M., Hottiger M.O., Georgiev O., et al. NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells. Biol Chem 386 (2005) 865-872
22. Nomura M., Yamagishi S., Harada S., Yamashima T., Yamashita J., and Yamamoto H. Placenta growth factor (PlGF) mRNA expression in brain tumors. J Neurooncol 40 (1998) 123-130
23. Torry R.J., Tomanek R.J., Zheng W., Miller S.J., Labarrere C.A., and Torry D.S. Hypoxia increases placenta growth factor expression in human myocardium and cultured neonatal rat cardiomyocytes. J Heart Lung Transplant 28 (2009) 183-190
24. Fischer C., Jonckx B., Mazzone M., Zacchigna S., Loges S., Pattarini L., et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cellule 131 (11-2-2007) 463-475
25. Kelly B.D., Hackett S.F., Hirota K., Oshima Y., Cai Z., Berg-Dixon S., et al. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 93 (2003) 1074-1081
26. Arany Z., Huang L.E., Eckner R., Bhattacharya S., Jiang C., Goldberg M.A., et al. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A 93 (11-12-1996) 12969-12973
27. Chang M., Mukherjea D., Gobble R.M., Groesch K.A., Torry R.J., and Torry D.S. Glial cell missing 1 regulates placental growth factor (PGF) gene transcription in human trophoblast. Biol Reprod 78 (2008) 841-851
28. Ziel K.A., Campbell C.C., Wilson G.L., and Gillespie M.N. Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene. Faseb J (2004)
29. Rapisarda A., Uranchimeg B., Scudiero D.A., Selby M., Sausville E.A., Shoemaker R.H., et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 62 (2002) 4316-4324
30. Arroyo J., Torry R.J., and Torry D.S. Deferential regulation of placenta growth factor (PlGF)-mediated signal transduction in human primary term trophoblast and endothelial Cells. Placenta 25 (2004) 379-386
31. Farr A., and Roman A. A pitfall of using a second plasmid to determine transfection efficiency. Nucleic Acids Res 20 (2-25-1992) 920
32. Yang W., Ahn H., Hinrichs M., Torry R.J., and Torry D.S. Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human trophoblast and endothelial cells. J Reprod Immunol 60 (2003) 53-60
33. Coulet F., Nadaud S., Agrapart M., and Soubrier F. Identification of hypoxia response element in the human endothelial nitric oxide synthase gene promoter. J Biol Chem (2003)
34. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25 (2001) 402-408
35. Hofmann W.A., Stojiljkovic L., Fuchsova B., Vargas G.M., Mavrommatis E., Philimonenko V., et al. Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nat Cell Biol 6 (2004) 1094-1101
36. Ebert B.L., and Bunn H.F. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol 18 (1998) 4089-4096
37. Rajakumar A., Brandon H.M., Daftary A., Ness R., and Conrad K.P. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 25 (2004) 763-769
38. Kimura H., Weisz A., Ogura T., Hitomi Y., Kurashima Y., Hashimoto K., et al. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem 276 (2001) 2292-2298
39. Bhattacharya S., and Ratcliffe P.J. ExCITED about HIF. Nat Struct Biol 10 (2003) 501-503
40. Chen K.F., Lai Y.Y., Sun H.S., and Tsai S.J. Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha. Nucleic Acids Res 33 (2005) 5190-5198
41. Fox S.B., Braganca J., Turley H., Campo L., Han C., Gatter K.C., et al. CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha. Cancer Res 64 (9-1-2004) 6075-6081
42. Nishimoto F., Sakata M., Minekawa R., Okamoto Y., Miyake A., Isobe A., et al. Metal transcription factor-1 is involved in hypoxia-dependent regulation of placenta growth factor in trophoblast-derived cells. Endocrinology (11-20-2008)
43. Chen C.P., Chen C.Y., Yang Y.C., Su T.H., and Chen H. Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia. Placenta 25 (2004) 413-421
44. Murphy B.J., Kimura T., Sato B.G., Shi Y., and Andrews G.K. Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha. Mol Cancer Res 6 (2008) 483-490
45. Rajakumar A., Brandon H.M., Daftary A., Ness R., and Conrad K.P. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 25 (2004) 763-769