A highly sensitive method for the determination of 7-aminonitrazepam, a metabolite of nitrazepam, in human urine using high-performance electrospray liquid chromatography tandem mass spectrometry

Biomedical Chromatography

Volumn 23, Issue 7, 2009, Pages 740-744

  Kuang, Hua ^a   Li, Qiusheng ^a   Shen, Chongyu ^b   Xu, Jinzhong ^b   Yuan, Yuan ^a   Xu, Chuanlai ^a   Wang, Wuyang ^c  

^a JIANGNAN UNIVERSITY   (China)

^b Jiangsu Import and Export Inspection and Quarantine Bureau   (China)

^c The Fourth Hospital in Wuxi   (China)

Author keywords

7 ANZP; Determination; Highly sensitive; HPELC MS

Indexed keywords

BODY FLUIDS; DRUG PRODUCTS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

7-AMINONITRAZEPAM; DETERMINATION; ELECTROSPRAYS; HIGHLY SENSITIVE; HPELC-MS; INTERNAL STANDARDS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; PERFORMANCE; SENSITIVE METHOD;

METABOLITES;

7 AMINO 1,3 DIHYDRO 5 PHENYL 2H 1,4 BENZODIAZEPIN 2 ONE; NITRAZEPAM; 7 AMINOCLONAZEPAM; 7-AMINOCLONAZEPAM; 7-AMINONITRAZEPAM; CLONAZEPAM; DRUG DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; LIQUID LIQUID EXTRACTION; PROCESS OPTIMIZATION; QUALITATIVE ANALYSIS; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; URINALYSIS; METABOLISM; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; URINE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONAZEPAM; HUMANS; LINEAR MODELS; NITRAZEPAM; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 70149096221     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1178     Document Type: Article

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