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Volumn 106, Issue 34, 2009, Pages 14287-14292

Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells

Author keywords

HDAC; Phosphorylation; Sumoylation

Indexed keywords

AGAR; ANTIGESTAGEN; GESTAGEN; GROWTH FACTOR; MIFEPRISTONE; PROGESTERONE RECEPTOR; PROMEGESTONE; PROTEIN KINASE;

EID: 70149092341     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905118106     Document Type: Article
Times cited : (62)

References (37)
  • 2
    • 1642441771 scopus 로고    scopus 로고
    • Progesterone Receptors in Mammary Gland Development and Tumorigenesis
    • DOI 10.1023/A:1025952924864, Transcription Factors in Mammary Gland Biology and Neoplasia
    • Conneely OM, Jericevic BM, Lydon JP (2003) Progesterone receptors in mammary gland development and tumorigenesis. J Mammary Gland Biol Neoplasia 8:205-214. (Pubitemid 38129942)
    • (2003) Journal of Mammary Gland Biology and Neoplasia , vol.8 , Issue.2 , pp. 205-214
    • Conneely, O.M.1    Jericevic, B.M.2    Lydon, J.P.3
  • 3
    • 0042978662 scopus 로고    scopus 로고
    • MAP kinases couple multiple functions of human progesterone receptors: Degradation, transcriptional synergy, and nuclear association
    • DOI 10.1016/S0960-0760(03)00221-8
    • Qiu M, Lange CA (2003) MAP kinases couple multiple functions of human progesterone receptors: Degradation, transcriptional synergy, and nuclear association. J Steroid Biochem Mol Biol 85:147-157. (Pubitemid 37020885)
    • (2003) Journal of Steroid Biochemistry and Molecular Biology , vol.85 , Issue.2-5 , pp. 147-157
    • Qiu, M.1    Lange, C.A.2
  • 4
    • 33846138978 scopus 로고    scopus 로고
    • Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivationandc-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells
    • Faivre EJ, Lange CA (2007) Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivationandc-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells. Mol Cell Biol 27:466-480.
    • (2007) Mol Cell Biol , vol.27 , pp. 466-480
    • Faivre, E.J.1    Lange, C.A.2
  • 5
    • 36849096094 scopus 로고    scopus 로고
    • Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells
    • Daniel AR, Faivre EJ, Lange CA (2007) Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells. Mol Endocrinol 21:2890-2906.
    • (2007) Mol Endocrinol , vol.21 , pp. 2890-2906
    • Daniel, A.R.1    Faivre, E.J.2    Lange, C.A.3
  • 7
    • 14844304709 scopus 로고    scopus 로고
    • Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology
    • Jacobsen BM, Schittone SA, Richer JK, Horwitz KB (2005) Progesterone-independent effects of human progesterone receptors (PRs) in estrogen receptor-positive breast cancer: PR isoform-specific gene regulation and tumor biology. Mol Endocrinol 19:574-587.
    • (2005) Mol Endocrinol , vol.19 , pp. 574-587
    • Jacobsen, B.M.1    Schittone, S.A.2    Richer, J.K.3    Horwitz, K.B.4
  • 9
    • 0037072795 scopus 로고    scopus 로고
    • The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression
    • DOI 10.1074/jbc.M204573200
    • Abdel-Hafiz H, Takimoto GS, Tung L, Horwitz KB (2002) The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression. J Biol Chem 277:33950-33956. (Pubitemid 35056210)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.37 , pp. 33950-33956
    • Abdel-Hafiz, H.1    Takimoto, G.S.2    Tung, L.3    Horwitz, K.B.4
  • 10
    • 0033967491 scopus 로고    scopus 로고
    • Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome
    • DOI 10.1073/pnas.97.3.1032
    • Lange CA, Shen T, Horwitz KB (2000) Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proc Natl Acad Sci USA 97:1032-1037. (Pubitemid 30080807)
    • (2000) Proceedings of the National Academy of Sciences of the United States of America , vol.97 , Issue.3 , pp. 1032-1037
    • Lange, C.A.1    Shen, T.2    Horwitz, K.B.3
  • 11
    • 0030775651 scopus 로고    scopus 로고
    • Biphasic regulation of breast cancer cell growth by progesterone: Role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1)
    • Groshong SD, et al. (1997) Biphasic regulation of breast cancer cell growth by progesterone: Role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1). Mol Endocrinol 11:1593-1607.
    • (1997) Mol Endocrinol , vol.11 , pp. 1593-1607
    • Groshong, S.D.1
  • 13
    • 0037385535 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors
    • DOI 10.1210/me.2002-0378
    • Qiu M, Olsen A, Faivre E, Horwitz KB, Lange CA (2003) Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors. Mol Endocrinol 17:628-642. (Pubitemid 36403575)
    • (2003) Molecular Endocrinology , vol.17 , Issue.4 , pp. 628-642
    • Qiu, M.1    Olsen, A.2    Faivre, E.3    Horwitz, K.B.4    Lange, C.A.5
  • 14
    • 0035726623 scopus 로고    scopus 로고
    • Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen-activated protein kinase-dependent phosphorylation of serine 294
    • DOI 10.1128/MCB.21.18.6122-6131.2001
    • Shen T, Horwitz KB, Lange CA (2001) Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen-activated protein kinase-dependent phosphorylation of serine 294. Mol Cell Biol 21:6122-6131. (Pubitemid 34263512)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.18 , pp. 6122-6131
    • Shen, T.1    Horwitz, K.B.2    Lange, C.A.3
  • 15
    • 0026006392 scopus 로고
    • cdc2 kinase activation in vertebrates
    • Krek W, Nigg EA (1991) Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: Evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J 10:3331-3341. (Pubitemid 21905358)
    • (1991) EMBO Journal , vol.10 , Issue.11 , pp. 3331-3341
    • Krek, W.1    Nigg, E.A.2
  • 16
    • 33645838628 scopus 로고    scopus 로고
    • Cyclin e as molecular marker in the management of breast cancer: A review
    • Lopez-Beltran A, MacLennan GT, Montironi R (2006) Cyclin E as molecular marker in the management of breast cancer: A review. Anal Quant Cytol Histol 28:111-114.
    • (2006) Anal Quant Cytol Histol , vol.28 , pp. 111-114
    • Lopez-Beltran, A.1    MacLennan, G.T.2    Montironi, R.3
  • 17
    • 33750453743 scopus 로고    scopus 로고
    • Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells
    • Byron SA, et al. (2006) Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells. Br J Cancer 95:1220-1228.
    • (2006) Br J Cancer , vol.95 , pp. 1220-1228
    • Byron, S.A.1
  • 18
    • 33847058518 scopus 로고    scopus 로고
    • Linkage of progestin and epidermal growth factor signaling: Phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth
    • Daniel AR, et al. (2007) Linkage of progestin and epidermal growth factor signaling: Phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth. Steroids 72:188-201.
    • (2007) Steroids , vol.72 , pp. 188-201
    • Daniel, A.R.1
  • 20
    • 0034326252 scopus 로고    scopus 로고
    • Effects of estrogen on global gene expression: Identification of novel targets of estrogen action
    • Charpentier AH, et al. (2000) Effects of estrogen on global gene expression: Identification of novel targets of estrogen action. Cancer Res 60:5977-5983.
    • (2000) Cancer Res , vol.60 , pp. 5977-5983
    • Charpentier, A.H.1
  • 21
    • 49649119768 scopus 로고    scopus 로고
    • Progesterone receptor action: Translating studies in breast cancer models to clinical insights
    • Lange CA, et al. (2008) Progesterone receptor action: Translating studies in breast cancer models to clinical insights. Adv Exp Med Biol 630:94-111.
    • (2008) Adv Exp Med Biol , vol.630 , pp. 94-111
    • Lange, C.A.1
  • 22
    • 1542285164 scopus 로고    scopus 로고
    • SUMO promotes HDAC-mediated transcriptional repression
    • DOI 10.1016/S1097-2765(04)00060-7, PII S1097276504000607
    • Yang SH, Sharrocks AD (2004) SUMO promotes HDAC-mediated transcriptional repression. Mol Cell 13:611-617. (Pubitemid 38299387)
    • (2004) Molecular Cell , vol.13 , Issue.4 , pp. 611-617
    • Yang, S.-H.1    Sharrocks, A.D.2
  • 23
    • 47249140920 scopus 로고    scopus 로고
    • Growth factor-induced phosphorylation of srebps inhibits sumoylation, thereby stimulating the expression of their target genes, LDL uptake and lipid synthesis
    • Arito M, Horiba T, Hachimura S, Inoue J, Sato R (2008) Growth factor-induced phosphorylation of srebps inhibits sumoylation, thereby stimulating the expression of their target genes, LDL uptake and lipid synthesis. J Biol Chem 283:15224-15231.
    • (2008) J Biol Chem , vol.283 , pp. 15224-15231
    • Arito, M.1    Horiba, T.2    Hachimura, S.3    Inoue, J.4    Sato, R.5
  • 24
    • 33750968212 scopus 로고    scopus 로고
    • PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus
    • Man JH, et al. (2006) PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus. Nucleic Acids Res 34:5552-5566.
    • (2006) Nucleic Acids Res , vol.34 , pp. 5552-5566
    • Man, J.H.1
  • 27
    • 0036185782 scopus 로고    scopus 로고
    • Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements
    • Hall JM, McDonnell DP, Korach KS (2002) Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. Mol Endocrinol 16:469-486.
    • (2002) Mol Endocrinol , vol.16 , pp. 469-486
    • Hall, J.M.1    McDonnell, D.P.2    Korach, K.S.3
  • 29
    • 0036112855 scopus 로고    scopus 로고
    • Loss of co-ordinate expression of progesterone receptors a and B is an early event in breast carcinogenesis
    • DOI 10.1023/A:1014820500738
    • Mote PA, Bartow S, Tran N, Clarke CL (2002) Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis. Breast Cancer Res Treat 72:163-172. (Pubitemid 34407211)
    • (2002) Breast Cancer Research and Treatment , vol.72 , Issue.2 , pp. 163-172
    • Mote, P.A.1    Bartow, S.2    Tran, N.3    Clarke, C.L.4
  • 30
    • 0028800157 scopus 로고
    • Characterization of progesterone receptor a and B expression in human breast cancer
    • Graham JD, et al. (1995) Characterization of progesterone receptor A and B expression in human breast cancer. Cancer Res 55:5063-5068.
    • (1995) Cancer Res , vol.55 , pp. 5063-5068
    • Graham, J.D.1
  • 32
    • 10044257416 scopus 로고    scopus 로고
    • Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2
    • Pierson-Mullany LK, Lange CA (2004) Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2. Mol Cell Biol 24:10542-10557.
    • (2004) Mol Cell Biol , vol.24 , pp. 10542-10557
    • Pierson-Mullany, L.K.1    Lange, C.A.2
  • 33
    • 0032553304 scopus 로고    scopus 로고
    • Convergence of progesterone and epidermal growth factor signaling in breast cancer: Potentiation of mitogen-activated protein kinase pathways
    • DOI 10.1074/jbc.273.47.31308
    • Lange CA, Richer JK, Shen T, Horwitz KB (1998) Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways. J Biol Chem 273:31308-31316. (Pubitemid 28533147)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.47 , pp. 31308-31316
    • Lange, C.A.1    Richer, J.K.2    Shen, T.3    Horwitz, K.B.4
  • 34
    • 0028026693 scopus 로고
    • New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: Only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP
    • Sartorius CA, et al. (1994) New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: Only antiprogestin- occupied B-receptors are switched to transcriptional agonists by cAMP. Cancer Res 54:3868-3877.
    • (1994) Cancer Res , vol.54 , pp. 3868-3877
    • Sartorius, C.A.1
  • 35
    • 0037308651 scopus 로고    scopus 로고
    • A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I
    • Sachdev D, et al. (2003) A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I. Cancer Res 63:627-635. (Pubitemid 36158140)
    • (2003) Cancer Research , vol.63 , Issue.3 , pp. 627-635
    • Sachdev, D.1    Li, S.-L.2    Hartell, J.S.3    Fujita-Yamaguchi, Y.4    Miller, J.S.5    Yee, D.6
  • 36
    • 34249339776 scopus 로고    scopus 로고
    • Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells
    • DOI 10.1158/0008-5472.CAN-06-3409
    • Ostrander JH, Daniel AR, Lofgren K, Kleer CG, Lange CA (2007) Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells. Cancer Res 67:4199-4209. (Pubitemid 46815066)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4199-4209
    • Ostrander, J.H.1    Daniel, A.R.2    Lofgren, K.3    Kleer, C.G.4    Lange, C.A.5
  • 37
    • 41649119043 scopus 로고    scopus 로고
    • Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors
    • Faivre EJ, Daniel AR, Hillard CJ, Lange CA (2008) Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors. Mol Endocrinol 22:823-837.
    • (2008) Mol Endocrinol , vol.22 , pp. 823-837
    • Faivre, E.J.1    Daniel, A.R.2    Hillard, C.J.3    Lange, C.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.