Anti-inflammatory and analgesic effects of the aqueous extract of corni fructus in murine RAW 264.7 macrophage cells

Journal of Medicinal Food

Volumn 12, Issue 4, 2009, Pages 788-795

  Sung, Yun Hee ^a   Chang, Hyun Kyung ^a,b   Kim, Sung Eun ^a   Kim, You Mi ^a   Seo, Jin Hee ^a   Shin, Min Chul ^a   Shin, Mal Soon ^a   Yi, Jae Woo ^c   Shin, Dong Hoon ^d   Kim, Hong ^e   Kim, Chang Ju ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Air Busan   (South Korea)

^c Kyung Hee University College of Medicine   (South Korea)

^d Korea University   (South Korea)

^e Daegu Haany University   (South Korea)

Author keywords

Corni fructus; Cyclooxygenase 2; Inducible nitric oxide synthase; Lipopolysaccharide; Nitric oxide; Nuclear factor B; Prostaglandin E 2

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETIC ACID; ACETYLSALICYLIC ACID; CORNI FRUCTUS EXTRACT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; BIOASSAY; CELL NUCLEUS; CONTROLLED STUDY; FRUIT; IMMUNE RESPONSE; IMMUNOASSAY; IN VIVO STUDY; MACROPHAGE; MALE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; WESTERN BLOTTING; WRITHING TEST;

ABDOMINAL PAIN; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CORNUS; CYCLOOXYGENASE 2; DINOPROSTONE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FRUIT; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; PLANT EXTRACTS;

CORNACEAE; CORNUS OFFICINALIS; MURINAE; MUS;

EID: 70149092329     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2008.1011     Document Type: Article

References (37)

1. Kota RS, Rutledge JC, Gohil K, Kumar A, Enelow RI, Ramana CV: Regulation of gene expression in RAW 264.7 macrophage cell line by interferon-g. Biochem Biophys Res Commun 2006;342:1137-1146.
2. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS: Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kB activation. Mutat Res 2001;480-481:243-268.
3. Bredt DS, Snyder SH: Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 1994;63:175-195.
4. Moalem G, Tracey DJ: Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev 2006;51:240-264.
5. Lappas M, Permezel M, Georgiou HM, Rice GE: Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro. Biol Reprod 2002;67:668-673.
6. Baeuerle PA, Henkel T: Function and activation of NF-kB in the immune system. Annu Rev Immunol 1994;12:141-179.
7. Sanchez-perez I, Benitah SA, Martinez-Gomariz M, Lacal JC, Perona R: Cell stress and MEKK1-mediated c-Jun activation modulate NFkB activity and cell viability. Mol Biol Cell 2002;13:2933-2945.
8. Hsu JH, Wu YC, Liu IM, Cheng JT: Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis. Neurosci Lett 2006;404:112-116.
9. Endo T, Taguchi H: Study on the constituents of Cornus offici-nalis Sieb. et Zucc. Yakugaku Zasshi 1973;93:30-32.
10. Lee SO, Kim SY, Han SM, Kim HM, Ham SS, Kang IJ: Corni fructus scavenges hydroxy radicals and decreases oxidative stress in endothelial cells. J Med Food 2006;9:594-598.
11. Yamahara J, Mibu H, Sawada T, Fujimura H, Takino S: Anti-diabetic principles of Corni fructus experimental diabetes induced by streptozotocin. Yakugaku Zasshi 1981;101:86-90.
12. Chang JS, Chiang LC, Hsu FF, Lin CC: Chemoprevention against hepatocellular carcinoma of Cornus officinalis in vitro. Am J Chin Med 2004;32:717-725.
13. Kang DG, Moon MK, Lee AS, Kwon TO, Kim JS, Lee HS: Cornuside suppresses cytokine-induced proinflammatory and adhesion molecules in the human umbilical vein endothelial cells. Biol Pharm Bull 2007;30:1796-1799.
14. Lee SJ, Shin EJ, Son KH, Chang HW, Kang SS, Kim HP: Anti-inflammatory activity of the major constituents of Lonicera japonica. Arch Pharm Res 1995;18:133-135.
15. Chang HK, Yang HY, Lee TH, Shin MC, Lee MH, Shin MS, Kim CJ, Kim OJ, Hong SP, Cho S: Armeniacae semen extract suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. Biol Pharm Bull 2005;28:449-454.
16. McGeer PL, McGeer EG: The inflammatory response system of brain: implications for therapy of Alzheimer and other neuro-degenerative diseases. Brain Res Brain Res Rev 1995;21:195-218.
17. Watkins LR, Maier SF: The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000;51:29-57.
18. Hinz B, Brune K, Pahl A: Prostaglandin E2 upregulates cyclo-oxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages. Biochem Biophys Res Commun 2000;272: 744-748. (Pubitemid 30420710)
19. Crofford LJ, Lipsky PE, Brooks P, Abramson SB, Simon LS, van de Putte LB: Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. Arthritis Rheum 2000;43:4-13.
20. Nathan C, Xie QW: Nitric oxide synthases: roles, tolls, and controls. Cell 1994;78:915-918.
21. Szabo C: Alterations in nitric oxide production in various forms of circulatory shock. New Horiz 1995;3:2-32.
22. MacMicking J, Xie QW, Nathan C: Nitric oxide and macrophage function. Annu Rev Immunol 1997;15:323-350.
23. Ohshima H, Bartsch H: Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 1994;305:253-264.
24. Posadas I, Terencio MC, Guillen I, Ferrandiz ML, Coloma J, Paya M, Alcaraz MJ: Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation. Naunyn Schmiedebergs Arch Pharmacol 2000;361:98-106. (Pubitemid 30064661)
25. Swierkosz TA, Mitchell JA, Warner TD, Botting RM, Vane JR: Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids. Br J Pharmacol 1995;114:1335-1342.
26. Jun CD, Choi BM, Kim HM, Chung HT: Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages. J Immunol 1995;154:6541-6547.
27. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA: Prostaglandin E2 mediates IL-1b-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol 2008;180:637-646.
28. Baeuerle PA: IkB-NF-kB structures: at the interface of inflammation control. Cell 1998;95:729-731.
29. Shin KM, Kim IT, Park YM, Ha J, Choi JW, Park HJ, Lee YS, Lee KT: Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E2, nitric oxide and tumor necrosis factor-a production. Biochem Pharmacol 2004;68:2327-2336.
30. Deraedt R, Jouquey S, Benzoni J, Peterfalvi M: Inhibition of prostaglandin biosynthesis by non-narcotic analgesic drugs. Arch Int Pharmacodyn Ther 1976;224:30-42.
31. Collier HO, Dinneen LC, Johnson CA, Schneider C: The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 1968;32:295-310.
32. Jang MH, Lim S, Han SM, Park HJ, Shin I, Kim JW, Kim MJ, Lee JS, Kim KA, Kim CJ: Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxy-genase-2 and inducible nitric oxide synthase in fibroblast cell line L929. J Pharmacol Sci 2003;93:367-371.
33. Xu H, Shen J, Liu H, Shi Y, Li L, Wei M: Morroniside and loganin extracted from Cornus officinalis have protective effects on rat mesangial cell proliferation exposed to advanced glycation end products by preventing oxidative stress. Can J Physiol Pharmacol 2006;84:1267-1273.
34. Nawa Y, Endo J, Ohta T: The inhibitory effect of the components of Cornus officinalis on melanogenesis. Int J Cosmet Sci 2008; 30:383-384.
35. Recio MC, Giner RM, Manez S, Rios JL: Structural considerations on the iridoids as anti-inflammatory agents. Planta Med 1994;60:232-234.
36. Kang SY, Yoon SY, Roh DH, Jeon MJ, Seo HS, Uh DK, Kwon YB, Kim HW, Han HJ, Lee HJ, Lee JH: The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. J Pharm Pharmacol 2008;60:1347-1354.
37. Kim SH, Jun CD, Suk K, Choi BJ, Lim H, Park S, Lee SH, Shin HY, Kim DK, Shin TY: Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol Sci 2006;91:123-131.