The role of deeper levels and ancillary studies (p16Ink4a and ProExC) in reducing the discordance rate of papanicolaou findings of high-grade squamous intraepithelial lesion and follow-up cervical biopsies

Cancer Cytopathology

Volumn 117, Issue 3, 2009, Pages 157-166

  David, Odile ^a   Cabay, Robert J ^a   Pasha, Seema ^a   Dietrich, Ruth ^a   Leach, Lu ^a   Guo, Meihua ^a   Mehrotra, Swati ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cervical biopsy; High grade squamous intraepithelial lesion; P16; ProExC; Sampling variation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; TUMOR MARKER;

ARTICLE; BIOPSY; CHEMISTRY; CYTOCHEMISTRY; DIFFERENTIAL DIAGNOSIS; FEMALE; FOLLOW UP; HUMAN; METABOLISM; PATHOLOGY; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX TUMOR; VAGINA SMEAR;

BIOPSY; CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; CERVIX UTERI; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOLLOW-UP STUDIES; HISTOCYTOCHEMISTRY; HUMANS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS;

EID: 70149086355     PISSN: None     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.20020     Document Type: Article

References (19)

1. Hearp ML, Locante AM, Ben-Rubin M, Dietrich R, David O. Validity of sampling error as a cause of noncorrelation. Cancer. 2007; 111: 275-279.
2. Solomon D, Nayar R, eds. The Bethesda System for Reporting Cervical Cytology. 2nd ed. New York, NY: SpringerVerlag; 2004.
3. Cramer H, Schlenk E. An analysis of discrepancies between the cervical cytologic diagnosis and subsequent histopathologic diagnosis in 1260 cases [abstract]. Acta Cytol. 1994; 39:812.
4. Ibrahim SN, Krigman HR, Coogan AC, et al. Prospective correlation of cervicovaginal cytologic and histologic specimens. Am J Clin Pathol. 1996; 106: 319-324.
5. Jones BA, Novis DA. Cervical biopsy-cytology correlation. A College of American Pathologists Q-Probes study of 22,439 correlations in 348 laboratories. Arch Pathol Lab Med. 1996; 120: 523-531.
6. Joste NE, Crum CP, Cibas ES. Cytologic/histologic correlation for quality control in cervicovaginal cytology: experience with 1,582 paired cases. Am J Clin Pathol. 1995; 103: 32-34.
7. Rohr LR. Quality assurance in gynecologic cytology: what is practical? Am J Clin Pathol. 1990; 94: 754-758.
8. Branca M, Ciotti M, Santini D, et al. p16(Ink4a) expression is related to grade of CIN and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome. Int J Gynecol Pathol. 2004; 23: 354-365.
9. von Knebel Doeberitz M. New molecular tools for efficient screening of cervical cancer. Dis Markers. 2001; 17: 123-128.
10. Duncan L, Jacob S, Hubbard E. Evaluation of p16INK4a as a diagnostic tool in the triage of Pap smears demonstrating atypical squamous cells of undetermined significance. Cancer. 2008; 114: 34-48.
11. Monsonego J, Pollini G, Evrard MJ, et al. p16(Ink4a) immunocytochemistry in liquid-based cytology samples in equivocal Pap smears: added value in management of women with equivocal Pap smear. Acta Cytol. 2007; 51: 755-766.
12. TriPath Molecular Oncology. Available at: http://www.bd.com/tripath/ products/proexc/sphase.asp#a Accessed on June 1, 2008.
13. Tambouret RH, Misdraji J, Wilbur DC. Longitudinal clinical evaluation of a novel antibody cocktail for detection of high-grade squamous intraepithelial lesions on cervical cytology specimens. Arch Pathol Lab Med. 2008; 132: 918-925.
14. Badr RE, Walts AE, Chung F, Bose S. BD ProEx C: a sensitive and specific marker of HPV-associated squamous lesions of the cervix. Am J Surg Pathol. 2008; 32: 899-906.
15. Shi J, Liu H, Wilkerson M, et al. Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions. Hum Pathol. 2007; 38: 1335-1344.
16. Ferris DG, Litaker MS, ALTS Group. Prediction of cervical histologic results using an abbreviated Reid Colposcopic Index during ALTS. Am J Obstet Gynecol. 2006; 194: 704-710.
17. Bonvicino A, Huitron S, Fadare O. Papanicolaou test interpretations of "atypical squamous cells, cannot exclude highgrade squamous intraepithelial lesion": an investigation of requisite duration and number of colposcopic procedures to a definitive diagnosis of high-grade dysplasia in routine practice. Cancer (Cancer Cytopathol). 2007; 111: 477-481.
18. Melnikow J, Nuovo J, Willan AR, Chan BK, Howell LP. Natural history of cervical squamous intraepithelial lesions: a meta-analysis. Obstet Gynecol. 1998; 92(4 pt 2): 727-735.
19. Hammes LS, Naud P, Passos EP, et al. Value of the International Federation for Cervical Pathology and Colposcopy (IFCPC) terminology in predicting cervical disease. J Low Genit Tract Dis. 2007; 11: 158-165.