Free radicals are present in human serum of Catha edulis Forsk (Khat) abusers

Journal of Ethnopharmacology

Volumn 125, Issue 3, 2009, Pages 471-473

  Al Akwa, Ahmed A ^a   Shaher, Monira ^b   Al Akwa, Sameeha ^b   Aleryani, Samir L ^c  

^a SANA A UNIVERSITY   (Yemen)

^b Ministry of Public Health   (Yemen)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Enzyme immunoassay (EIA); Free radicals; Organophosphates (OPs); Serum acetyl cholinesterase (AChE)

Indexed keywords

ACETYLCHOLINESTERASE; AMPHETAMINE; FREE RADICAL; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

ADULT; AGE DISTRIBUTION; ANTIOXIDANT ACTIVITY; ARTICLE; CATHA EDULIS; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; EATING HABIT; ENZYME ACTIVITY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PROTEIN SYNTHESIS INHIBITION; SUBSTANCE ABUSE;

ACETYLCHOLINESTERASE; ADULT; ANTIOXIDANTS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CATHA; DRUG USERS; FREE RADICALS; HUMANS; MALE; MASTICATION; MIDDLE AGED;

CATHA EDULIS;

EID: 70049116603     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.07.012     Document Type: Article

References (24)

1. Ahmed M., Azmi A., Naqvi S.N.H., Arshad Azmi M., and Aslam M. Effect of pesticide residues on health and different enzyme levels in the blood of farm workers from Gadap (rural area). Chemosphere 64 (2006) 1739-1744
2. Ahmed M.B., and El-Qirbi A.B. Biochemical effects of Catha edulis, cathine and cathinone on adrenocortical functions. Journal of Ethnopharmacology 39 (1993) 213-216
3. Al-Ahdal M.N., Mcgarry T.J., and Hannan M.A. Cytotoxicity of Khat (Catha edulis) extract on cultured mammalian cells: effects on macromolecule biosynthesis. Mutation Research 204 (1988) 317-322
4. Aleryani S., Milo E., and Kostka P. Formation of peroxynitrite during thiol-mediated reduction of sodium nitroprusside. Biochimica et Biophysica Acta 1472 (1999) 181-190
5. Aleryani S., Milo E., and Kostka P. Superoxide-mediated decomposition of biological S-nitrosothiols. Journal of Biological Chemistry 273 (1998) 6041-6045
6. Al-Hebshi N.N., Nielsen O., and Skaug N. In vitro effects of crude khat extracts on the growth, colonization, and glucosyltransferases of Streptococcus mutans. Acta Odontologica Scandinavica 63 (2005) 136-142
7. Al-Habori M. The potential adverse effects of habitual use of Catha edulis (khat). Expert Opinion on Drug Safety 4 (2005) 1145-1154
8. Ali A.A., Al-Sharabi A.K., Aguirre J.M., and Nahas R. A study of 342 oral keratotic white lesions induced by qat chewing among 2500 Yemeni. Journal of Oral Pathology and Medicine 33 (2004) 368-372
9. Ali A.A., Al-Sharabi A.K., and Aguirre J.M. Histopathological changes in oral mucosa due to takhzeen al-qat: a study of 70 biopsies. Journal of Oral Pathology and Medicine 35 (2006) 81-85
10. Al-Motarreb A., Baker K., and Broadley K.J. Khat: pharmacological and medical aspects and its social use in Yemen. Phytotherapy Research 16 (2002) 403-413
11. Al-Qirim T.M., Shahwan M., Zaidi K.R., Uddin Q., and Banu N. Effect of Khat, its constituents and restraint stress on free radical metabolism of rats. Journal of Ethnopharmacology 83 (2002) 245-250
12. Awadh A.N.A., Lemme D., Jira Th., Attef O., and Al-rahwi K. Determination of pesticide residues in Khat leaves by solid-phase extraction and high-performance liquid chromatography. African Journal of Traditional CAM 3 (2006) 1-10
13. Clemens M.R. Free radicals in chemical carcinogenesis. Klinische Wochenschrift 69 (1991) 1123-1134
14. Date J., Tanida N., and Hobara T. Qat chewing and pesticides: a study of adverse health effects in people of the mountainous areas of Yemen. International Journal of Environmental Health Research 14 (2004) 405-414
15. Dimba E., Gjertsen B.T., Francis G.W., Johannessen A.C., and Vintermyr O.K. Catha edulis (Khat) induces cell death by apoptosis in leukemia cell lines. Annals of the New York Academy of Sciences 1010 (2003) 384-388
16. Grzelak A., Soszyn Ski M., and Bartosz G. Inactivation of antioxidant enzymes by peroxynitrite. Scandinavian Journal of Clinical and Laboratory Investigation 60 (2000) 253-258
17. Islam M.W., Tariq M., Ageel A.M., E1-Feraly F.S., A1-Meshal I.A., and Ashraf I. An evaluation of the male reproductive toxicity of cathinone. Toxicology 60 (1990) 223-234
18. Kalix P. A constituent of Khat leaves with amphetamine-like releasing properties. European Journal of Pharmacology 68 (1980) 213-215
19. Kassie F., Darroudi F., Kundi M., Schulte-Hermann R., and Knasmüller S. Khat (Catha edulis) consumption causes genotoxic effects in humans. International Journal of Cancer 92 (2001) 329-332
20. Lukandu O.M., Costea D.E., Neppelberg E., Johannessen A.C., and Vintermyr O.K. Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts. Toxicological Sciences 103 (2008) 311-324
21. Ranjbar A., Pasalar P., and Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers. Human & Experimental Toxicology 21 (2002) 179-182
22. Samuel T.K., and Nyongesa A.W. Effects of single daily khat (Catha edulis) extract on spatial learning and memory in CBA mice. Behavioural Brain Research 195 2008 (2008) 192-197
23. World Bank. Yemen Economic Update (2005). http://www.worldbank.org/
24. World Health Organization, 2002-2007. Regional Office for the Eastern Mediterranean Country Cooperation. Country Cooperation Strategy for WHO and the Republic of Yemen.