Optimal drug combinations and minimal hitting sets

BMC Systems Biology

Volumn 3, Issue , 2009, Pages

  Vazquez, Alexei ^a,b  

^a INSTITUTE FOR ADVANCED STUDY   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS;

ANTINEOPLASTIC AGENT;

ARTICLE; DRUG SCREENING; HUMAN; IC 50; METHODOLOGY; NEOPLASM; PATHOLOGY; SYSTEMS BIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; NEOPLASMS; SYSTEMS BIOLOGY;

EID: 70049113642     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-3-81     Document Type: Article

References (11)

1. Borisy AA Elliott PJ Hurst NW Lee MS Lehár J Price ER Serbedzija G Zimmermann GR Foley MA Stockwell BR Keith CT Systematic discovery of multicomponent therapeutics Proc Natl Acad Sci USA 2003, 100:7977-7982. 10.1073/pnas.1337088100 164698 12799470
2. Shoemaker RH The NCI60 human tumour cell line anticancer drug screen Nature Rev Cancer 2006, 6:813-823. 10.1038/nrc1951
3. wong PK Yu F Shahangian A Cheng G Sun R Ho C Closed-loop control of cellular functions using combinatory grugs guided by a stochastic search algorithm Proc Natl Acad Sci USA 2008, 105:5105-5110. 10.1073/ pnas.0800823105 2278193 18356295
4. Yildirim MA Goh KL Cusick M Barabási AL Vidal M Drug-target network Nature Biotech 2007, 25:1119-1126. 10.1038/nbt1338
5. Nelander S Wang W Nilsson B She QB Pratilas C Rosen N Gennemark P Sander C Models from experiments: Combinatorial drug perturbations of cancer cells Mol Syst Biol 2008, 4:216. 10.1038/msb.2008.53 2564730 18766176
6. Campillo M Kuhn M Gavin A jensen LJ Bork P Drug target identification using side effect similarity Science 2008, 321:263-266. 10.1126/ science.1158140 18621671
7. Garey MR Johnson DS Computers and intractability: A guide to the theory of NP-completeness WH Freeman, New York 2002
8. Vazirani V Approximation Algorithms Springer, Berlin 2004
9. Johnson DS Approximation algorithms for combinatorial problems J Comp Syst Sci 1974, 9:256-278.
10. Teachey DT Sheen C Hall J Ryan T Brown VI Fish J Reid GS Seif AE Norris R Chang YJ Carroll M Grupp SA mTOR inhibitors are synergistic with methetrexate: An effective combination to treat acute lymphoblastic leukemia Blood 2008, 112:2020-2023. 10.1182/blood-2008-02-137141 18544682 2518903
11. Mézard M Tarzia M Statistical mechanics of the hitting set problem Phys Rev E 2007, 76:041124. 10.1103/PhysRevE.76.041124