What is the clinical relevance of different lung compartments?

BMC Pulmonary Medicine

Volumn 9, Issue , 2009, Pages

  Tschernig, Thomas ^a   Pabst, Reinhard ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANATOMICAL CONCEPTS; ANATOMICAL VARIATION; ARTICLE; CELLULAR DISTRIBUTION; HUMAN; IMMUNE RESPONSE; INFLAMMATORY DISEASE; LEUKOCYTE ADHERENCE; LUNG BLOOD VESSEL; LUNG FUNCTION; LUNG INTERSTITIUM; LUNG LAVAGE; LUNG LYMPH; LUNG MECHANICS; LUNG PARENCHYMA; LYMPH NODE; MUCOSAL IMMUNITY; NONHUMAN; PULMONARY ARTERY; RESPIRATORY TRACT MUCOSA; ADAPTIVE IMMUNITY; CYTOLOGY; EDITORIAL; HISTOLOGY; IMMUNOLOGY; INNATE IMMUNITY; LEUKOCYTE; LUNG; LUNG DISEASE; LYMPHOCYTE; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULARIZATION;

ADAPTIVE IMMUNITY; BRONCHOALVEOLAR LAVAGE FLUID; HUMANS; IMMUNITY, INNATE; LEUKOCYTES; LUNG; LUNG DISEASES; LYMPHOCYTES; RESPIRATORY MUCOSA;

EID: 70049111920     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-9-39     Document Type: Article

References (18)

1. Pabst R Tschernig T Lymphocytes in the lung: An often neglected cell. Numbers, characterization and compartmentalization Anat Embryol 1995, 192:293-9. 10.1007/BF00710098 8554162
2. Pabst R Tschernig T Lymphocyte dynamics: Caution in interpreting BAL numbers Thorax 1997, 52:1078-80. 1758469 9516903
3. Meyer KC Bronchoalveolar lavage as a diagnostic tool Semin Respir Crit Care Med 2007, 28:546-60. 10.1055/s-2007-991527 17975782
4. Lehmann C Wilkening A Leiber D Markus A Krug N Pabst R Tschernig T Lymphocytes in the bronchoalveolar space reenter the lung tissue by means of the alveolar epithelium, migrate to regional lymph nodes, and subsequently rejoin the systemic immune system Anat Rec 2001, 264:229-36. 10.1002/ar.1163 11596005
5. Tschernig T Kleemann WJ Pabst R Bronchus-associated lymphoid tissue (BALT) in the lungs of children who had died from sudden infant death syndrome and other causes Thorax 1995, 50:658-60. 10.1136/thx.50.6.658 1021267 7638809
6. Tschernig T Pabst R Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases Pathobiology 2000, 68:1-8. 10.1159/000028109 10859525
7. Brandtzaeg P Pabst R Let's go mucosal: Communication on slippery ground Trends Immunol 2004, 25:570-7. 10.1016/j.it.2004.09.005 15489184
8. Pabst R Durak D Roos A Lührmann A Tschernig T TLR2/6 stimulation of the rat lung: Effects on lymphocyte subsets, natural killer cells and dendritic cells in different parts of the air-conducting compartments and at different ages Immunology 2009, 126:132-9. 10.1111/ j.1365-2567.2008.02886.x 18565128
9. Synek M Beasley R Frew AJ Goulding D Holloway L Lampe FC Roche WR Holgate ST Cellular infiltration of the airways in asthma of varying severity Am J Respir Crit Care Med 1996, 154:224-30. 8680684
10. Tschernig T de Vries VC Debertin AS Braun A Walles T Traub F Pabst R Density of dendritic cells in the human tracheal mucosa is age dependent and site specific Thorax 2006, 61:986-91. 10.1136/thx.2006.060335 16893947
11. van Tongeren J Reinartz SM Fokkens WJ de Jong EC van Drunen CM Interactions between epithelial cells and dendritic cells in airway immune responses: Lessons from allergic airway disease Allergy 2008, 63:1124-35. 10.1111/j.1398-9995.2008.01791.x 18699930
12. Tschernig T Neumann D Pich A Dorsch M Pabst R Experimental bronchial asthma the strength of the species rat Curr Drug Targets 2008, 9:466-9. 10.2174/138945008784533543 18537585
13. Burri PH Morphology and respiratory function of the alveolar unit Int Arch Allergy Appl Immunol 1985, 76(S1):2-12. 10.1159/000233728 3838533
14. Pabst R Tschernig T Perivascular capillaries in the lung: An important but neglected vascular bed in immune reactions? J Allergy Clin Immunol 2002 110 209 14 10.1067/mai.2002.126836 12170259
15. Reppe K Tschernig T Lührmann A van Laak V Grote K Zemlin MV Gutbier B Müller HC Kursar M Schütte H Rosseau S Pabst R Suttorp N Witzenrath M Immunostimulation with macrophage-activating lipopeptide-2 increased survival in murine pneumonia Am J Respir Cell Mol Biol 2009, 40:474-81. 10.1165/rcmb.2008-0071OC 18931326
16. Gill SS Suri SS Janardhan KS Caldwell S Duke T Singh B Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model Respir Res 2008, 9:69. 10.1186/1465-9921-9-69 2584635 18950499
17. Winkler GC Review of the significance of pulmonary intravascular macrophages with respect to animal species and age Exp Cell Biol 1989, 57:281-6. 2519957
18. Warner AE Brain JD The cell biology and pathogenic role of pulmonary intravascular macrophages Am J Physiol 1990, 258:L1-12. 2407136