A dual role for HSP90 and HSP70 in the inflammatory myopathies: From muscle fiber protection to active invasion by macrophages

Annals of the New York Academy of Sciences

Volumn 1173, Issue , 2009, Pages 463-469

  De Paepe, Boel ^a   Creus, Kim K ^a   Martin, Jean Jacques ^b   Weis, Joachim ^c   De Bleecker, Jan L ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Heat shock proteins; Inflammatory myopathy; Myocytotoxicity; Myoprotection

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; INDUCIBLE NITRIC OXIDE SYNTHASE;

CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DERMATOMYOSITIS; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; IMMUNOHISTOCHEMISTRY; MUSCLE BIOPSY; MUSCLE CELL; MUSCLE REGENERATION; MUSCULAR DYSTROPHY; MYOSITIS; POLYMYOSITIS; PROTEIN EXPRESSION; SKELETAL MUSCLE; SPORADIC INCLUSION BODYMYOSITIS; UPREGULATION;

EID: 70049097249     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04812.x     Document Type: Conference Paper

References (33)

1. Craig, E.A., B.D. Gambill & R.J. Nelson. 1993. Heat-shock proteins-Molecular chaperones of protein biogenesis. Moll. Cell. Biol. 13: 5637-5646.
2. Tavaria, M. et al. 1996. A hitchhiker's guide to the human Hsp70. Cell. Stress Chaperon. 1: 23-28.
3. Kiang, J.G. & G.C. 1998. Heat shock protein 70 kDa: Molecular biology, biochemistry, and physiology. Pharmacol. Ther. 80: 183-201.
4. Jacob, U. et al. 1995. Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase: Implications for heat shock in vivo. J. Biol. Chem. 270: 7288-7294.
5. Richter, K. & J. Buchner. 2001. Hsp90: chaperoning signal transduction. J. Cell. Physiol. 188: 281-290.
6. Singh-Jasuja, H. et al. 2000. Cross-presentation of gly-coprotein 96-associated antigens on major histocom-patibility complex class I molecules requires receptor-mediated endocytosis. J. Exp. Med. 191: 1965-1974.
7. Kuppner, M.C. et al. 2001. The role of heat shock protein (hsp70) in dendritic cell maturation: hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors. Eur. J. Immunol. 31: 1602-1609.
8. Asea, A. et al. 2000. HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cy-tokine. Nat. Med. 6: 435-442.
9. Srivastava, P. 2002. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 20: 395-425.
10. Haug, M. et al. 2005. The heat shock protein Hsp70 enhances antigen-specific proliferation of human CD4+ memory T cells. Eur. J. Immunol. 35: 3163-3172.
11. Cohen-Sfady, M. et al. 2005. Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway. J. Immunol. 175: 3594-3602.
12. Askanas, V. & W.K. Engel. 2007. Inclusion-body myositis, a multifactorial muscle disease associated with aging: current concepts of pathogenesis. Curr. Opin. Rheumatol. 19: 550-559.
13. De Bleecker, J.L. & B. De Paepe. 2003. The idio-pathic inflammatory myopathies. Adv. Clin. Neurosc. 13: 353-378.
14. Bornmann, L., B.S. Polla & G.S. Gericke. 1996. Heat shock protein 90 and ubiquitin: developmental regulation during myogenesis. Muscle Nerve 19: 574-580.
15. Bornmann, L. et al. 1995. Expression of heat-shock/stress proteins in Duchenne muscular dystrophy. Muscle Nerve 19: 574-580.
16. Fratta, P. et al. 2005. Proteasome inhibition and ag-gresome formation in sporadic inclusion-body myosi-tis and in amyloid-b precursor protein-overexpressing cultured human muscle fibers. Am. J. Pathol. 167: 517-526.
17. Ibi, T. et al. 1995. Expression of the heat shock protein 70 in inflammatory myopathies. Rinsho Shinkeigaku 35: 1163-1166.
18. Zheng, Z. et al. 2005. HSP70 inhibits NFkB activation and IkB phosphorylation following experimental stroke. Neurology 64: A180.
19. De Bleecker, J.L., K.K. Creus & B. De Paepe. 2007. The distribution of NF-κB and its inhibitor in the idiopathic inflammatory myopathies. J. Neurol. 254: III/10.
20. Malhotra, V. et al. 2001. Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human respiratory epithelium. Am. J. Respir. Cell. Mol. Biol. 25: 92-97.
21. Chan, J.Y.H. et al. 2004. Heat shock protein 70 confers cardiovascular protection during endotoxemia via inhibition of nuclear factor-kB activation and in-ducible nitric oxide synthase expression in the rostral ventrolateral medulla. Circulation 110: 3560-3566.
22. Yoshida, M. & Y. Xia. 2003. Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. J. Biol. Chem. 278: 36953-36958.
23. Fontana, J. et al. 2002. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ. Res. 90: 866-873.
24. Song, Y., J.L. Zweier & Y. Xia. 2001. Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy. Biochem. J. 355: 357-360.
25. Tews, D.S. & H.H. Goebel. 1998. Cell death and oxidative damage in inflammatory myopathies. Clin. Immunol. Immunopathol. 87: 240-247.
26. De Paepe, B. et al. 2004. Expression and distribution of the nitric oxide synthases in idiopathic inflammatory myopathies. Acta Neuropathol. 108: 37-42.
27. De Paepe, B., K.K. Creus & J.L. De Bleecker. 2008. Chemokines in idiopathic inflammatory myopathies. Front. Biosci. 13: 2548-2577.
28. Nagarsekar, A. & J.D. Hasday, I.S. 2005. CXC chemokines: a new family of heat-shock proteins? Immunol. Invest. 34: 381-398.
29. De Paepe, B. et al. 2005. Alpha-chemokine receptors CXCR1-3 and their ligands in idiopathic inflammatory myopathies. Acta Neuropathol. 109: 576-582.
30. Poulaki, V. et al. 2007. Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis. FA S E B J. 21: 2113-2123.
31. Waza, M. et al. 2006. Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein. J. Mol. Med. 84: 635-646.
32. Murakami, Y. et al. 1991. Uehara Y, Yamamoto C, Fukazawa H, Mizuno S. Induction of hsp72/73 by herbimycin A, an inhibitor of transformation by tyro-sine kinase oncogenes. Exp. Cell. Res. 195: 338-344.
33. McArdle, A. et al. 2004. Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age-related muscle dysfunction. FA S E B J. 18: 355-357.