Oxygen-ozone therapy in medicine: An update

Blood Purification

Volumn 28, Issue 4, 2009, Pages 373-376

  Bocci, Velio ^a   Di Paolo, Nicola ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY HOSPITAL OF SIENA   (Italy)

Author keywords

Antioxidants; Chronic oxidative stress; Dentistry; Ozone; Vascular diseases

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

CARDIOVASCULAR DISEASE; CHILD; ERYTHROPOIESIS; HEART MUSCLE ISCHEMIA; HUMAN; IMMUNE SYSTEM; IMMUNOSTIMULATION; OXYGEN THERAPY; OZONE THERAPY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SHORT SURVEY; UPREGULATION; VIRUS INFECTION;

CARDIOVASCULAR DISEASES; HUMANS; ISCHEMIA; OXYGEN; OXYGEN INHALATION THERAPY; OZONE; VIRUS DISEASES;

EID: 70049096088     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000236365     Document Type: Short Survey

References (38)

1. Wolff HH: Die Behandlung peripherer Durchblutungsstörungen mit Ozon. Erfahr Hk 1974; 23: 181-184.
2. Bocci V: Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006; 37: 425-435.
3. Bocci V: The case for oxygen-ozonetherapy. Br J Biomed Sci 2007; 64: 44-49. (Pubitemid 46952972)
4. Bocci V: The question of balance: The interaction between blood and ozone; in Valacchi G, Davis P (eds): Oxidants in Biology. Dordrecht, Springer, 2008, pp 155-165.
5. Bocci V, Borrelli E, Travagli V, Zanardi I: The ozone paradox: Ozone is a strong oxidant as well as a medical drug. Med Res Rev 2009; 29: 646-682.
6. Bocci V: Oxygen-Ozone Therapy. A Critical Evaluation. Dordrecht, Kluwer Academic, 2002, p 440.
7. Bocci V: Ozone. A new medical drug. Dordrecht, Springer, 2005, p 295.
8. Shinriki N, Suzuki T, Takama K, Fukunaga K, Ohgiya S, Kubota K, Miura T: Susceptibilities of plasma antioxidants and erythrocyte constituents to low levels of ozone. Haematologia 1998; 29: 229-239.
9. Bocci V, Aldinucci C: Biochemical modifications induced in human blood by oxygenation- ozonation. J Biochem Mol Toxicol 2006; 20: 133-138.
10. Travagli V, Zanardi I, Silvietti A, Bocci V: A physicochemical investigation on the effects of ozone on blood. Int J Biol Macromol 2007; 41: 504-511.
11. Halliwell B: Antioxidant defence mechanisms: from the beginning to the end (of the beginning). Free Radic Res 1999; 31: 261-272.
12. Mendiratta S, Qu ZC, May JM: Erythrocyte ascorbate recycling: Antioxidant effects in blood. Free Radic Biol Med 1998; 24: 789-797.
13. Last JA, Gohil K, Mathrani VC, Kenyon NJ: Systemic responses to inhaled ozone in mice: Cachexia and down-regulation of liver xenobiotic metabolizing genes. Toxicol Appl Pharmacol 2005; 208: 117-126.
14. Jerrett M, Burnett RT, Pope CA 3rd, et al: Long-term ozone exposure and mortality. N Engl J Med 2009; 360: 1085-1095.
15. Goldstein BD, Balchum OJ: Effect of ozone on lipid peroxidation in the red blood cell. Proc Soc Exp Biol Med 1967; 126: 356-359.
16. Valacchi G, Bocci V: Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets. Mediators Inflamm 1999; 8: 205-209. (Pubitemid 30019330)
17. Valacchi G, Bocci V: Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells. Mediators Inflamm 2000; 9: 271-276.
18. Stamler JS: S-nitrosothiols in the blood: Roles, amounts, and methods of analysis. Circ Res 2004; 94: 414-417.
19. Bocci V, Paulesu L: Studies on the biological effects of ozone. 1. Induction of interferon gamma on human leucocytes. Haematologica 1990; 75: 510-515.
20. Bocci V, Luzzi E, Corradeschi F, Paulesu L, Di Stefano A: Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines. Lymphokine Cytokine Res 1993; 12: 121-126.
21. Bocci V, Valacchi G, Corradeschi F, Fanetti G: Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production. Mediators Inflamm 1998; 7: 313-317.
22. Bocci V: Does ozone therapy normalize the cellular redox balance? Med Hypotheses 1996; 46: 150-154.
23. Calabrese EJ: Paradigm lost, paradigm found: The re-emergence of hormesis as a fundamental dose response model in the toxicological sciences. Environ Pollut 2005; 138: 379-411.
24. Bocci V, Aldinucci C, Mosci F, Carraro F, Valacchi G: Ozonation of human blood induces a remarkable upregulation of heme oxygenase- 1 and heat stress protein-70. Mediators Inflamm 2007; 2007: 26785.
25. Bocci V: Is it true that ozone is always toxic? The end of the dogma. Toxicol Appl Pharmacol 2006; 216: 493-504.
26. Bocci V, Di Paolo N, Garosi G, et al: Ozonation of blood during extracorporeal circulation. 1. Rationale, methodology and preliminary studies. Int J Artif Organs 1999; 22: 645-651.
27. Di Paolo N, Bocci V, Cappelletti F, Petrini G, Gaggiotti E: Necrotizing fasciitis successfully treated with extracorporeal blood oxygenation and ozonization (EBOO). Int J Artif Organs 2002; 25: 1194-1198.
28. Di Paolo N, Bocci V, Salvo DP, et al: Extracorporeal blood oxygenation and ozonation (EBOO): A controlled trial in patients with peripheral artery disease. Int J Artif Organs 2005; 28: 1039-1050.
29. De Monte A, van der Zee H, Bocci V: Major ozonated autohemotherapy in chronic limb ischemia with ulcerations. J Altern Complement Med 2005; 11: 363-367.
30. Bocci V, Venturi G, Catucci M, Valensin PE, Zazzi M: Lack of efficacy of ozone therapy in HIV infection. Clin Microbiol Infect 1998; 4: 667-669.
31. Burgassi S, Zanardi I, Travagli V, Montomoli M, Bocci V: How much ozone bactericidal activity is compromised by plasma components? J Appl Microbiol 2009; 106: 1715-1721.
32. Sechi LA, Lezcano I, Nunez N, et al: Antibacterial activity of ozonized sunflower oil (Oleozon). J Appl Microbiol 2001; 90: 279-284.
33. Valacchi G, Fortino V, Bocci V: The dual action of ozone on the skin. Br J Dermatol 2005; 153: 1096-1100.
34. Torre Amione G, Anker SD, Bourge RC, et al: Results of a non-specific immunomodulation therapy in chronic heart failure (ACCLAIM trial): A placebo-controlled randomised trial. Lancet 2008; 371: 228-236.
35. Sliva K, Ansari AA: Immunosuppression as therapy for congestive heart failure. Lancet 2008; 371: 184-186.
36. Bocci V: The failure of the ACCLAIM trial is due to an irrational technology. Int J Cardiol 2008 [Epub ahead of print].
37. Muto M, Ambrosanio G, Guarnieri G: Low back pain and sciatica: Treatment with intradiscal- intraforaminal O(2)-O(3) injection. Our experience. Radiol Med 2008; 113: 695-706.
38. Lynch E: The Revolution in Dentistry. Copenhagen, Quintessence, 2004, p 300.