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Volumn 21, Issue 10, 2009, Pages

Stimulatory action of mitemcinal (GM-611), an acid-resistant non-peptide motilin receptor agonist, on colonic motor activity and defecation: Spontaneous and mitemcinal-induced giant migrating contractions during defecation in dogs

Author keywords

Colon; Constipation; Defecation; Giant migrating contraction (GMC); Mitemcinal; Motilin agonist

Indexed keywords

MITEMCINAL; PLACEBO; SENNOSIDE;

EID: 70049093574     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01341.x     Document Type: Article
Times cited : (4)

References (53)
  • 1
    • 21244488587 scopus 로고    scopus 로고
    • Managing constipation in advanced cancer care
    • Perdue C. Managing constipation in advanced cancer care. Nurs Times 2005 101 : 36 40.
    • (2005) Nurs Times , vol.101 , pp. 36-40
    • Perdue, C.1
  • 3
    • 0000415399 scopus 로고
    • The movements of the intestines studied by means of the Roentgen rays
    • Cannon WB. The movements of the intestines studied by means of the Roentgen rays. Am J Physiol 1902 66 : 251 277.
    • (1902) Am J Physiol , vol.66 , pp. 251-277
    • Cannon, W.B.1
  • 4
    • 0001444346 scopus 로고
    • Die normale peristalitik de kolon
    • Holtzknecht G. Die normale peristalitik de kolon. Münch Med Wochenschr 1909 56 : 2401 2403.
    • (1909) Münch Med Wochenschr , vol.56 , pp. 2401-2403
    • Holtzknecht, G.1
  • 6
    • 0028901590 scopus 로고
    • Prolonged ambulatory canine colonic motility
    • Gastrointest. Liver. Physiol. 31
    • Scott SM, Pilot M-A, Barnett TG, Williams NS. Prolonged ambulatory canine colonic motility. Am J Physiol 1995 268 (Gastrointest. Liver. Physiol. 31 G650 62.
    • (1995) Am J Physiol , vol.268 , pp. 650-62
    • Scott, S.M.1    Pilot, M.-A.2    Barnett, T.G.3    Williams, N.S.4
  • 7
    • 0029097856 scopus 로고
    • Effect of motilin on colonic motor activity in the interdigestive state in conscious dogs
    • Shibata C, Sasaki I, Naito H et al. Effect of motilin on colonic motor activity in the interdigestive state in conscious dogs. Tohoku J Exp Med 1995 176 : 53 60.
    • (1995) Tohoku J Exp Med , vol.176 , pp. 53-60
    • Shibata, C.1    Sasaki, I.2    Naito, H.3
  • 8
    • 33846025894 scopus 로고    scopus 로고
    • Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract
    • Takeshita E, Matsuura B, Dong M, Miller LJ, Matsui H. Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract. J Gastroenterol 2006 41 : 223 230.
    • (2006) J Gastroenterol , vol.41 , pp. 223-230
    • Takeshita, E.1    Matsuura, B.2    Dong, M.3    Miller, L.J.4    Matsui, H.5
  • 9
    • 44349174338 scopus 로고    scopus 로고
    • Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine
    • Ter Beck WP, Muller ES, van den Berg M, Meijer MJ, Biemond I, Lamers CB. Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine. Inflamm Bowel Dis 2008 14 : 612 619.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 612-619
    • Ter Beck, W.P.1    Muller, E.S.2    Van Den Berg, M.3    Meijer, M.J.4    Biemond, I.5    Lamers, C.B.6
  • 10
    • 0035110786 scopus 로고    scopus 로고
    • 2+signaling induced by motilin and erythromycin in the circular muscle of human colon
    • 2+signaling induced by motilin and erythromycin in the circular muscle of human colon. Neurogatroenterol Motil 2001 13 : 27 35.
    • (2001) Neurogatroenterol Motil , vol.13 , pp. 27-35
    • Van Asshe, G.1    Depoortere, I.2    Thijs, T.3
  • 11
    • 0027332459 scopus 로고
    • Effect of motilin and erythromycin on the motor activity of the human colon
    • Bradette M, Poitras P, Bovin M. Effect of motilin and erythromycin on the motor activity of the human colon. J Gastrointest Motil 1993 5 : 247 251.
    • (1993) J Gastrointest Motil , vol.5 , pp. 247-251
    • Bradette, M.1    Poitras, P.2    Bovin, M.3
  • 12
    • 0026731924 scopus 로고
    • Oral or intravenous erythromycin has no effect on human distal colonic motility
    • Jameson JS, Rogers J, Raimundo AH, Henry MM. Oral or intravenous erythromycin has no effect on human distal colonic motility. Aliment Pharmacol Ther 1992 6 : 589 595.
    • (1992) Aliment Pharmacol Ther , vol.6 , pp. 589-595
    • Jameson, J.S.1    Rogers, J.2    Raimundo, A.H.3    Henry, M.M.4
  • 13
    • 0028238747 scopus 로고
    • Potent, acid-stable and orally active macrolide-type motilin receptor agonists, GM-611 and the derivatives
    • Koga H, Sato T, Tsuzuki K, Onoda H, Kuboniwa H, Takanashi H. Potent, acid-stable and orally active macrolide-type motilin receptor agonists, GM-611 and the derivatives. Bioorg Med Chem Lett 1994 4 : 1347 1352.
    • (1994) Bioorg Med Chem Lett , vol.4 , pp. 1347-1352
    • Koga, H.1    Sato, T.2    Tsuzuki, K.3    Onoda, H.4    Kuboniwa, H.5    Takanashi, H.6
  • 14
    • 34247387931 scopus 로고    scopus 로고
    • In vitropharmacological characterization of mitemcinal(GM-611), the first acid-resistant nonpeptide motilin receptor agonist, in smooth muscle of rabbit small intestine
    • Takanashi H, Yogo K, Ozaki K, Koga H, Ito Z, Omura S. In vitropharmacological characterization of mitemcinal(GM-611), the first acid-resistant nonpeptide motilin receptor agonist, in smooth muscle of rabbit small intestine. Pharmacology 2007 79 : 137 148.
    • (2007) Pharmacology , vol.79 , pp. 137-148
    • Takanashi, H.1    Yogo, K.2    Ozaki, K.3    Koga, H.4    Ito, Z.5    Omura, S.6
  • 15
    • 34249824906 scopus 로고    scopus 로고
    • Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs
    • DOI 10.1159/000101537
    • Ozaki K, Yogo K, Sudo H et al. Effects of Mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs. Pharmacology 2007 79 : 223 235. (Pubitemid 46848542)
    • (2007) Pharmacology , vol.79 , Issue.4 , pp. 223-235
    • Ozaki, K.-I.1    Yogo, K.2    Sudo, H.3    Onoma, M.4    Kamei, K.5    Akima, M.6    Koga, H.7    Itoh, Z.8    Omura, S.9    Takanashi, H.10
  • 16
    • 34250029161 scopus 로고    scopus 로고
    • Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: A randomized, multi-center, placebo-controlled trial
    • US Investigative Team.
    • McCallum RW, Cynshi O, US Investigative Team. Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: a randomized, multi-center, placebo-controlled trial. Aliment Pharmacol Ther 2007 26 : 107 116.
    • (2007) Aliment Pharmacol Ther , vol.26 , pp. 107-116
    • McCallum, R.W.1    Cynshi, O.2
  • 17
    • 34848856142 scopus 로고    scopus 로고
    • Effects of motilin and mitemcinal (GM-611) on gastrointestinal contractile activity in rhesus monkeys in vivo and in vitro
    • DOI 10.1007/s10620-006-9672-5
    • Yogo K, Ozaki K, Takanashi H, Koto M, Itoh Z, Omura S. Effects of motilin and mitemcinal (GM-611) on gastrointestinal contractile activity in rhesus monkeys in vivo and in vitro. Dig Dis Sci 2007 52 : 3112 3122. (Pubitemid 47512532)
    • (2007) Digestive Diseases and Sciences , vol.52 , Issue.11 , pp. 3112-3122
    • Yogo, K.1    Ozaki, K.-I.2    Takanashi, H.3    Koto, M.4    Itoh, Z.5    Omura, S.6
  • 18
    • 33847408372 scopus 로고    scopus 로고
    • Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs
    • Ozaki K, Sudo H, Muramatsu K et al. Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs. Inflammopharmacol 2007 15 : 36 42.
    • (2007) Inflammopharmacol , vol.15 , pp. 36-42
    • Ozaki, K.1    Sudo, H.2    Muramatsu, K.3
  • 19
    • 33947515694 scopus 로고    scopus 로고
    • Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools
    • Sudo H, Ozaki K, Muramatsu H et al. Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools. Neurogastroenterol Motil 2007 19 : 318 326.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 318-326
    • Sudo, H.1    Ozaki, K.2    Muramatsu, H.3
  • 22
    • 70049110963 scopus 로고
    • An extraluminal train gage force transducer: Its construction and implantation
    • Japanese).
    • Ito Z. An extraluminal train gage force transducer: its construction and implantation. J Smooth Muscle Res 1976 13 : 3 43 Japanese).
    • (1976) J Smooth Muscle Res , vol.13 , pp. 3-43
    • Ito, Z.1
  • 23
    • 0023099843 scopus 로고
    • Giant migrating contraction during defecation in the dog colon
    • Karaus M, Sarna SK. Giant migrating contraction during defecation in the dog colon. Gastroenterology 1987 92 : 925 933.
    • (1987) Gastroenterology , vol.92 , pp. 925-933
    • Karaus, M.1    Sarna, S.K.2
  • 24
    • 0021414321 scopus 로고
    • Colonic migrating and nonmigrating motor complexes in dogs
    • Sarna SK, Condon R, Cowles V. Colonic migrating and nonmigrating motor complexes in dogs. Am J Physiol 1984 246 : G355 60.
    • (1984) Am J Physiol , vol.246 , pp. 355-60
    • Sarna, S.K.1    Condon, R.2    Cowles, V.3
  • 25
  • 28
    • 0142011163 scopus 로고    scopus 로고
    • Manometric techniques for the evaluation of colonic motor activity: Current status
    • Scott SM. Manometric techniques for the evaluation of colonic motor activity: current status. Neurogastroenterol Motil 2003 15 : 483 513.
    • (2003) Neurogastroenterol Motil , vol.15 , pp. 483-513
    • Scott, S.M.1
  • 31
    • 0038819418 scopus 로고    scopus 로고
    • Circadian rhythm of rectal reactivity in individuals with regular and irregular bowel evacuation
    • Shemerovskii KA. Circadian rhythm of rectal reactivity in individuals with regular and irregular bowel evacuation. Bull Exp Biol Med 2002 134 : 565 567.
    • (2002) Bull Exp Biol Med , vol.134 , pp. 565-567
    • Shemerovskii, K.A.1
  • 32
    • 0001968128 scopus 로고
    • The innervation of the pelvic of the pelvic and adjoining viscera. Part I: The lower portion of the intestine
    • Langley JN, Anderson HK. The innervation of the pelvic of the pelvic and adjoining viscera. Part I: the lower portion of the intestine. J Physiol 1895 18 : 67 105.
    • (1895) J Physiol , vol.18 , pp. 67-105
    • Langley, J.N.1    Anderson, H.K.2
  • 33
    • 0001968126 scopus 로고
    • The innervation of the pelvic of the pelvic and adjoining viscera. Part V: Position of the nerve cells on the course of the efferntnerve fibers
    • Langley JN, Anderson HK. The innervation of the pelvic of the pelvic and adjoining viscera. Part V: position of the nerve cells on the course of the efferntnerve fibers. J Physiol 1896 19 : 131 139.
    • (1896) J Physiol , vol.19 , pp. 131-139
    • Langley, J.N.1    Anderson, H.K.2
  • 34
    • 84944486397 scopus 로고
    • The innervation of the pelvic of the pelvic and adjoining viscera. Part VI: Histological and physiological observations upon the effects of section of the sacral nerves
    • Langley JN, Anderson HK. The innervation of the pelvic of the pelvic and adjoining viscera. Part VI: histological and physiological observations upon the effects of section of the sacral nerves. J Physiol 1896 19 : 372 384.
    • (1896) J Physiol , vol.19 , pp. 372-384
    • Langley, J.N.1    Anderson, H.K.2
  • 35
    • 0001968130 scopus 로고
    • The innervation of the pelvic of the pelvic and adjoining viscera. Part VII: Anatomical Observations
    • Langley JN, Anderson HK. The innervation of the pelvic of the pelvic and adjoining viscera. Part VII: anatomical Observations. J Physiol 1896 19 : 385 406.
    • (1896) J Physiol , vol.19 , pp. 385-406
    • Langley, J.N.1    Anderson, H.K.2
  • 36
    • 84944484700 scopus 로고
    • The movement and the innervation of the large intestine
    • Bayliss WM, Starling EH. The movement and the innervation of the large intestine. J Physiol 1900 26 : 107 118.
    • (1900) J Physiol , vol.26 , pp. 107-118
    • Bayliss, W.M.1    Starling, E.H.2
  • 37
    • 0001379140 scopus 로고
    • Antiperistalsis and other muscular activities of the colon
    • Elliot TR, Barclay-Smith E. Antiperistalsis and other muscular activities of the colon. J Physiol 1904 31 : 272 304.
    • (1904) J Physiol , vol.31 , pp. 272-304
    • Elliot, T.R.1    Barclay-Smith, E.2
  • 38
    • 0001329201 scopus 로고
    • An investigation of the nervous control of defection
    • Denny-Brown D, Robertson C. An investigation of the nervous control of defection. Brain 1935 58 : 256 310.
    • (1935) Brain , vol.58 , pp. 256-310
    • Denny-Brown, D.1    Robertson, C.2
  • 39
    • 0031698346 scopus 로고    scopus 로고
    • Cooperative roles of colon and anorectum during spontaneous defecation in conscious dogs
    • Matsuhuji H, Yokoyama J, Hirabayashi T, Watanabe S, Sakurai K. Cooperative roles of colon and anorectum during spontaneous defecation in conscious dogs. Dig Dis Sci 1998 43 : 2042 2047.
    • (1998) Dig Dis Sci , vol.43 , pp. 2042-2047
    • Matsuhuji, H.1    Yokoyama, J.2    Hirabayashi, T.3    Watanabe, S.4    Sakurai, K.5
  • 41
    • 0002544240 scopus 로고
    • The normal movements of the colon in man
    • Hertz AF, Newton A. The normal movements of the colon in man. J Physiol (Lond) 1913 47 : 57 65.
    • (1913) J Physiol (Lond) , vol.47 , pp. 57-65
    • Hertz, A.F.1    Newton, A.2
  • 42
    • 0010511684 scopus 로고
    • The Huxley lecture on the caecum and appendix
    • Macewen W. The Huxley lecture on the caecum and appendix. Lancet 1904 2 : 995 1000.
    • (1904) Lancet , vol.2 , pp. 995-1000
    • MacEwen, W.1
  • 43
    • 0020069319 scopus 로고
    • Glucagon, gastric inhibitory polypeptide and the gastrocolic response
    • Strom JA, Condon RE, Schutle WJ, Coweles V, Go VL. Glucagon, gastric inhibitory polypeptide and the gastrocolic response. Am J Surg 1982 143 : 155 159.
    • (1982) Am J Surg , vol.143 , pp. 155-159
    • Strom, J.A.1    Condon, R.E.2    Schutle, W.J.3    Coweles, V.4    Go, V.L.5
  • 45
    • 0028207565 scopus 로고
    • Effect of erythromycin on gastric and gallbladder emptying and gastrointestinal symptons in scleroderma patients is maintained medium term
    • Fiorucci S, Distrutti E, Gerli R, Morelli A. Effect of erythromycin on gastric and gallbladder emptying and gastrointestinal symptons in scleroderma patients is maintained medium term. Am J Gastroenterol 1994 89 : 550 555.
    • (1994) Am J Gastroenterol , vol.89 , pp. 550-555
    • Fiorucci, S.1    Distrutti, E.2    Gerli, R.3    Morelli, A.4
  • 46
    • 0028791574 scopus 로고
    • Effect of oral erythromycin on colonic transit in patients with idiopathic constipation. A pilot study
    • Sharma SS, Bhargava N, Mathur SC. Effect of oral erythromycin on colonic transit in patients with idiopathic constipation. A pilot study. Dig Dis Sci 1995 40 : 2446 2449.
    • (1995) Dig Dis Sci , vol.40 , pp. 2446-2449
    • Sharma, S.S.1    Bhargava, N.2    Mathur, S.C.3
  • 48
    • 38149094261 scopus 로고    scopus 로고
    • Molecular identification and characterization of the dog motilin receptor
    • Ohshiro H, Nonaka M, Ishikawa K. Molecular identification and characterization of the dog motilin receptor. Regul Pept 2008 146 : 80 7.
    • (2008) Regul Pept , vol.146 , pp. 80-7
    • Ohshiro, H.1    Nonaka, M.2    Ishikawa, K.3
  • 49
    • 0029097856 scopus 로고
    • Effect of motilin on colonic motor activity in the interdigestive state in conscious dogs
    • Shibata C, Sasaki I, Naito H et al. Effect of motilin on colonic motor activity in the interdigestive state in conscious dogs. Tohoku J Exp Med 1995 176 : 53 60.
    • (1995) Tohoku J Exp Med , vol.176 , pp. 53-60
    • Shibata, C.1    Sasaki, I.2    Naito, H.3
  • 50
    • 0023262443 scopus 로고
    • Laxative consumption in chronic nonorganic constipation
    • Corazziari E, Materia E, Bausano G et al. Laxative consumption in chronic nonorganic constipation. J Clin Gastroenterol 1987 9 : 427 430.
    • (1987) J Clin Gastroenterol , vol.9 , pp. 427-430
    • Corazziari, E.1    Materia, E.2    Bausano, G.3
  • 51
    • 0018601596 scopus 로고
    • Metabolic activation of sennoside A in mice
    • Sasaki K, Yamauchi K, Kuwano S. Metabolic activation of sennoside A in mice. Planta Med 1979 37 : 370 378.
    • (1979) Planta Med , vol.37 , pp. 370-378
    • Sasaki, K.1    Yamauchi, K.2    Kuwano, S.3
  • 52
    • 0021895367 scopus 로고
    • 2 synthesis and water and electrolyte secretion by senna anthraquinones is inhibited by indomethacin
    • 2 synthesis and water and electrolyte secretion by senna anthraquinones is inhibited by indomethacin. J Pharm Pharmacol 1985 37 : 248 251.
    • (1985) J Pharm Pharmacol , vol.37 , pp. 248-251
    • Beubler, E.1    Kollar, G.2
  • 53
    • 0023713609 scopus 로고
    • Changes in colonic motility induced by sennosides in dogs: Evidence of a prostaglandin mediation
    • Staumont G, Fioramonti J, Frexinos J, Bueno L. Changes in colonic motility induced by sennosides in dogs: evidence of a prostaglandin mediation. Gut 1988 29 : 1180 1187.
    • (1988) Gut , vol.29 , pp. 1180-1187
    • Staumont, G.1    Fioramonti, J.2    Frexinos, J.3    Bueno, L.4


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