Association between MTHFR 677C-T polymorphism and alcohol dependence according to Lesch and Babor typology: BRIEF REPORT

Addiction Biology

Volumn 14, Issue 4, 2009, Pages 503-505

  Benyamina, Amine ^a,b   Saffroy, Raphaël ^c,d   Blecha, Lisa ^a,b   Pham, Patrick ^c,d   Karila, Laurent ^a,b   Debuire, Brigitte ^c,d   Lemoine, Antoinette ^c,d   Reynaud, Michel ^a,b  

^a HÔPITAL PAUL BROUSSE   (France)

^b Universite Paris Sud   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d INSERM   (France)

Author keywords

Alcohol dependence; Babor typology; Depression; Homocysteine; Lesch typology; Methylenetetrahydrofolate reductase polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALCOHOL DERIVATIVE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADDICTION; ADULT; ALCOHOLISM; AMINO ACID METABOLISM; ARTICLE; DEPRESSION; ENZYME ACTIVITY; FEMALE; GENE FUNCTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; METABOLISM; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; PRIORITY JOURNAL;

EID: 70049089344     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2009.00169.x     Document Type: Article

References (10)

1. Babor TF, Hofmann M, DelBoca FK, Hesselbrock V, Meyer RE, Dolinsky ZS, Rounsaville B (1992) Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 49 : 599 608.
2. Bjelland I, Tell GS, Vollset SE, Refsum H, Ueland PM (2003) Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry 60 : 618 626.
3. Hesselbrock MN, Hesselbrock V, Del Boca F (2001) Typology of alcoholism, gender and 20-year mortality. Alcohol Clin Exp Res 25 : 151A.
4. Hesselbrock VM, Hesselbrock MN (2006) Are there empirically supported and clinically useful subtypes of alcohol dependence? Addiction 101 (Suppl. 1 97 103.
5. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93 : 7 9. (Pubitemid 26006560)
6. Leggio L, Kenna GA, Fenton M, Bonenfant E, Swift RM (2009) Typologies of alcohol dependence. From jellinek to genetics and beyond. Neuropsychol Rev 19 : 115 129.
7. Lesch OM, Kefer J, Lentner S, Mader R, Marx B, Musalek M, Nimmerrichter A, Preinsberger H, Puchinger H, Rustembegovic A, Walter H, Zach E (1990) Diagnosis of chronic alcoholism - classificatory problems. Psychopathology 23 : 88 96.
8. Lutz UC, Batra A, Wiatr G, Machicao F, Kolb W, Maurer S, Buchkremer G, Kohnke MD (2007) Significant impact of MTHFR C677T polymorphism on plasma homovanillic acid (HVA) levels among alcohol-dependent patients. Addict Biol 12 : 100 105.
9. Saffroy R, Benyamina A, Pham P, Marill C, Karila L, Reffas M, Debuire B, Reynaud M, Lemoine A (2008) Protective effect against alcohol dependence of the thermolabile variant of MTHFR. Drug Alcohol Depend 96 : 30 36.
10. Tokgozoglu SL, Alikasifoglu M, Unsal Atalar E, Aytemir K, Ozer N, Ovunc K, Usal O, Kes S, Tuncbilek E (1999) Methylene tetrahydrofolate reductase genotype and the risk and extent of coronary artery disease in a population with low plasma folate. Heart 81 : 518 522.