Development of a first-responder fluorescence reader for microarray cytokine assay of human immune response to disease

Materials Research Society Symposium Proceedings

Volumn 1004, Issue , 2007, Pages 96-101

  Fenner, David B ^a   Rosen, David I ^a   Ferrante, Anthony A ^a   Stevens, Amy E ^a   Bigelow, Chad E ^a   Davis, Steven J ^a  

^a PHYSICAL SCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAB-ON-A-CHIP; NANOSTRUCTURES; OPTICAL DESIGN;

CYTOKINES; FIRST RESPONDERS; HUMAN DISEASE; HUMAN SALIVA; IMMUNE RESPONSE; LED EXCITATION; MINIMALLY PROCESSED;

FLUORESCENCE;

EID: 70049085515     PISSN: 02729172     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1557/proc-1004-p03-26     Document Type: Conference Paper

References (16)

1. D. Kobasa, et al, "Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus, " Nature 445, 319 (2007).
2. "Doctor says 'spit please', " Nature, news, 22 March 2007, and references therein.
3. F. Chiappelli, F.J. Iribarren and P. Prolo, "Salivary biomarkers in psychobiological medicine, " Bioinformation 1, 331 (2006).
4. F.G. Hayden, et al, "Local and systematic cytokine responses during experimental human influenza A virus infection, " J. Clinical Invest. 101, 643 (1998).
5. D.P. Skoner, et al, "Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virus, " J. Infect. Diseases 180, 10 (1999).
6. R.B. Turner, et al, "Association between interlukin-8 concentrations in nasal secretions and severity of symptoms of experimental rhinovirus colds, " Clinical Infect. Diseases 26, 840(1998).
7. N.L Rhodus, et al, "The feasibility of monitoring NF-kB associated cytokines: TNF-α, IL-lα, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus, " Molecular Carcinogenesis 44, 77 (2005).
8. E.A. Lilly, et al, "Tissue-associated cytokine expression in HIV-positive persons with oropharyngeal candidiasis, " J. Infect. Diseases 190, 605 (2004).
9. D. Lucini, et al, "Hemodynamic and autonomic adjustments to real life stress conditions in humans, " Hypertension 39, 184 (2002).
10. K.L. Wozniak, "Inhibitory effects of whole and parotid saliva on immunomodulators, " Oral Microbiology Immunology 17, 100 (2002).
11. Novagen ProteoPlex™ 16-well human cytokine array kit, supplied by EMD Biosciences Inc., Madison, WI. Information at: www.emdbiosciences.com/ novagen
12. G. Mazzini et al, "Improvements in fluorescence microscopy allowed by high power light emitting diodes, " Cur. Issues Multidisciplinary Microscopy Res. Ed., ed. A. Mendez-Vilas and L. Labajos-Broncano (Formatex, 2004) pp. 181-189.
13. GenePix 4000 scanner with laser illumination, and measured courtesy of Novagen.
14. FluMist™ is a live influenza virus, approved by the FDA for intranasal vaccination, and distributed by Medlmmune Vaccines, Inc., Gaithersburg, MD.
15. The human use research study was approved by IRB at AFRL, Wright-Patterson AFB.
16. In preparation.