Epidemiology and outcomes of Clostridium difficile-associated disease among patients on prolonged acute mechanical ventilation

Chest

Volumn 136, Issue 3, 2009, Pages 752-758

  Zilberberg, Marya D ^a,b,g   Nathanson, Brian H ^c   Sadigov, Shamil ^a   Higgins, Thomas L ^d   Kollef, Marin H ^e   Shorr, Andrew F ^f  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b EviMed Research Group LLC   (United States)

^c OptiStatim LLC   (United States)

^d BAYSTATE MEDICAL CENTER   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f WASHINGTON HOSPITAL CENTER   (United States)

^g UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE RESPIRATORY FAILURE; AGED; ARTICLE; ARTIFICIAL VENTILATION; ASPIRATION PNEUMONIA; BRAIN HEMORRHAGE; BRAIN INFARCTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ASSESSMENT; CLOSTRIDIUM DIFFICILE INFECTION; CONFIDENCE INTERVAL; CONGESTIVE HEART FAILURE; COST EFFECTIVENESS ANALYSIS; DISEASE EXACERBATION; FEMALE; HOSPITAL ADMISSION; HOSPITAL COST; HOSPITAL DISCHARGE; HOSPITAL INFECTION; HUMAN; INCIDENCE; INFECTION PREVENTION; INTERNATIONAL CLASSIFICATION OF DISEASES; LENGTH OF STAY; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PNEUMONIA; PRIORITY JOURNAL; PROLONGED ACUTE MECHANICAL VENTILATION; PSEUDOMONAS PNEUMONIA; RESOURCE ALLOCATION; RISK ASSESSMENT; SEPTICEMIA;

EID: 70049084784     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.09-0596     Document Type: Article

References (29)

1. Zilberberg MD, Luippold RS, Sulsky S, et al. Prolonged acute mechanical ventilation, hospital resource utilization and mortality in a US cohort. Crit Care Med 2008; 36:724-730
2. Zilberberg MD, de Wit M, Pirone JR, et al. Growth in adult prolonged acute mechanical ventilation: implications for healthcare delivery. Crit Care Med 2008; 36:1451-1455
3. Zilberberg MD, Shorr AF, Kollef MH. Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000-2005. Emerg Infect Dis 2008; 14:929-931
4. Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005; 353:2442-2449
5. McDonald LC, Killgore GE, Thompson A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005; 353:2433-2441
6. Centers for Disease Control and Prevention. Severe Clostridium difficile-associated disease in populations previously at low risk: four states, 2005. MMWR Morb Mortal Wkly Rep 2005; 54:1201-1205
7. Centers for Disease Control and Prevention. Surveillance for community-associated Clostridium difficile: Connecticut, 2006. MMWR Morb Mortal Wkly Rep 2008; 57:340-343
8. Zilberberg MD, Shorr AF, Kollef MH. Increase in Clostridium difficile-related hospitalizations among infants in the US, 2000-2005. Pediatr Infect Dis J 2008; 27:1111-1113
9. Kenneally C, Rosini JM, Skrupky LP, et al. Analysis of 30-day mortality for Clostridium difficile-associated disease in the ICU setting. Chest 2007; 132:418-424
10. Agency for Healthcare Research and Quality. Healthcare cost and utilization project nationwide inpatient sample. Available at: http://www.hcup-us.ahrq.gov/nisoverview.jsp. Accessed June 16, 2009
11. Elixhauser A, Steiner C, Harris DR, et al. Comorbidity measures for use with administrative data. Med Care 1998; 36:8-27 (Pubitemid 128456396)
12. Dehejia RH, Wahba S. Propensity score matching methods for non-experimental causal studies. Rev Econ Stat 2002; 84:151-161
13. D'Agostino RB Jr. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med 1998; 17:2265-2281
14. Kurth T, Walker AM, Glynn RJ, et al. Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol 2006; 163:262-270 (Pubitemid 43145754)
15. Zilberberg MD, Shorr AF. Projections for growth in adult prolonged acute mechanical ventilation: ICU and hospital bed numbers implications. BMC Health Serv Res 2008; 8:242
16. Pepin J, Valiquette L, Alary ME. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. Can Med Assoc J 2004; 171:466-472
17. Muto CA, Pokrywka M, Shutt K, et al. A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Infect Control Hosp Epidemiol 2005; 26:273-280
18. Redelings MD, Sorvillo F, Mascola L. Increase in Clostridium difficile-related mortality rates, United States, 1999-2004. Emerg Infect Dis 2007; 13:1417-1419
19. Warny M, Pepin J, Fong A, et al. Toxin production by an emerging strain of Clostridium difficile associated outbreaks of severe disease in North America and Europe. Lancet 2005; 366:1079-1084
20. Centers for Disease Control and Prevention. Data and statistics about Clostridium difficile infections. Available at: http://www.cdc.gov/ncidod/dhqp/ id-Cdiff-data.html. Accessed June 16, 2009
21. McDonald LC, Owings M, Jernigan DB. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg Infect Dis 2006; 12:409-415
22. Marra AR, Edmond MB, Wenzel RP, et al. Hospital-acquired Clostridium difficile-associated disease in the intensive care unit setting: epidemiology, clinical course and outcome. BMC Infect Dis 2007; 7:42
23. Zilberberg MD, Shorr AF, Kollef MH. Growth and geographic variation in hospitalizations with resistant infections, United States, 2000-2005. Emerg Infect Dis 2008; 14:1756-1758
24. Elixhauser A, Jhung M. Clostridium difficile-associated disease in US hospitals, 1993-2005. Available at: http://www.hcup-us.ahrq.gov/reports/ statbriefs/sb50.pdf. Accessed June 16, 2009
25. Dubberke ER, Reske KA, McDonald LC, et al. ICD-9 codes and surveillance for Clostridium difficile-associated disease. Emerg Infect Dis 2006; 12:1576-1579
26. Carson SS, Cox CE, Holmes GM, et al. The changing epidemiology of mechanical ventilation: a population-based study. J Intensive Care Med 2006; 21:173-182
27. Cox CE, Carson SS, Holmes GM, et al. Increase in tracheostomy for prolonged mechanical ventilation in North Carolina, 1993-2002. Crit Care Med 2004; 32:2219-2226
28. Valiquette L, Cossette B, Garant MP, et al. Impact of a reduction in the use of high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain. Clin Infect Dis 2007; 45(suppl):S112-S121
29. McMullen KM, Zack J, Coopersmith CM, et al. Use of hypochlorite solution to decrease rates of Clostridium difficile-associated diarrhea. Infect Control Hosp Epidemiol 2007; 28:205-207