Problematic melanocytic lesions in children

Expert Review of Dermatology

Volumn 4, Issue 3, 2009, Pages 249-261

  Moscarella, Elvira ^a   Zalaudek, Iris ^b   Ferrara, Gerardo ^c   Manzo, Manuela ^a   Savarese, Imma ^a   Argenziano, Giuseppe ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c G RUMMO HOSPITAL   (Italy)

Author keywords

Children; Clinical diagnosis; Dermoscopy; Histopathologic diagnosis; Melanocytic nevus; Melanoma

Indexed keywords

AGMINATED NEVUS; BLUE NEVUS; CANCER MORTALITY; CANCER RISK; CHILD; CLINICAL FEATURE; CONGENITAL NEVUS; CONSERVATIVE TREATMENT; DIFFERENTIAL DIAGNOSIS; DYSPLASTIC NEVUS; EPILUMINESCENCE MICROSCOPY; HUMAN; HYPERPIGMENTATION; JUVENILE MELANOMA; LEUKODERMA; MELANOCYTIC NEVUS; MELANOMA; MELANOSIS; NEVUS SPILUS; PRIORITY JOURNAL; REVIEW; RISK FACTOR; TARGETOID HEMOSIDEROTIC NEVUS;

EID: 69949178316     PISSN: 17469872     EISSN: None     Source Type: Journal    
DOI: 10.1586/edm.09.22     Document Type: Review

References (127)

1. Scalzo DA, Hida CA, Toth G, Sober AJ, Mihm MC Jr. Childhood melanoma: a clinicopathological study of 22 cases. Melanoma Res. 7, 63-68 (1997).
2. Fraitag S. Melanocytic nevi in children. Ann. Pathol. 24, 587-604 (2004).
3. Ferrari A, Bono A, Baldi M et al. Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution. Pediatrics 115, 649-654 (2005).
4. Wechsler J, Bastuji-Garin S, Spatz A et al.; French Cutaneous Cancerology Group. Reliability of the histopathologic diagnosis of malignant melanoma in childhood. Arch. Dermatol. 138, 625-628 (2002).
5. Paredes B, Hardmeier T. Spitz nevus and Reed nevus: simulating melanoma in adults. Pathologe 119, 403-411 (1998).
6. Leman JA, Evans A, Mooi W, MacKie RM Outcomes and pathological review of a cohort of children with melanoma. Br. J. Dermatol. 152, 1321-1323 (2005).
7. Huynh PM, Grant-Kels JM, Grin CM. Childhood melanoma: update and treatment. Int. J. Dermatol. 44, 715-723 (2005).
8. Richardson SK, Tannous ZS, Milhm MC Jr. Congenital and infantile melanoma: review of the literature and report of an uncommon variant, pigment-synthesizing melanoma. J. Am. Acad. Dermatol. 47, 77-90 (2002).
9. Kanzler MH, Mraz-Gernhard S. Primary cutaneous malignant melanoma and its precursor lesions: diagnostic and therapeutic overview. J. Am. Acad. Dermatol. 45, 260-276 (2001).
10. Bonifazi E, Bilancia M, Berloco A, Ciampo L, De Roma MR. Malignant melanoma in children aged 0-12. Review of 289 cases of the literature. Eur. J. Pediat. Dermatol. 11, 157-175 (2001).
11. Argenziano G, Soyer HP, Chimenti S et al. Dermoscopy of pigmented skin: results of a consensus meeting via the Internet. J. Am. Acad. Dermatol. 48, 679-693 (2003).
12. Argenziano G, Soyer HP. Dermoscopy of pigmented skin lesions. A valuable tool for early diagnosis of melanoma. Lancet Oncol. 2, 443-449 (2001).
13. Soyer HP, Argenziano G, Talamini R, Chimenti S. Is dermoscopy useful for the diagnosis of melanoma? Arch. Dermatol. 137, 1361-1363 (2001).
14. Pehamberger H, Steiner A, Wolff K. In vivo epiluminescence microscopy of pigmented skin lesions. I. Pattern analysis of pigmented skin lesions. J. Am. Acad. Dermatol. 117, 571-583 (1987).
15. Worret WI, Burgdorf WH. Which direction do nevus cells move? Abtropfung reexamined. Am. J. Dermatopathol. 20, 135-139 (1998).
16. Bauer J, Buttner P, Wiecker TS, Luther H, Garbe C. Effect of sunscreen and clothing on the number of melanocytic nevi in 1,812 German children attending day care. Am. J. Epidemiol. 161, 620-627 (2005).
17. Oliveria SA, Geller AC, Dusza SW et al. The Framingham school nevus study: a pilot study. Arch. Dermatol. 140, 545-551 (2004).
18. Zalaudek I, Grinschgl S, Argenziano G et al. Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi. Br. J. Dermatol. 154, 299-304 (2006).
19. Aguilera P, Puig S, Guilabert A et al. Prevalence study of nevi in children from Barcelona. Dermoscopy, constitutional and environmental factors. Dermatology 218(3), 203-214 (2009).
20. Westhafer J, Gildea J, Klepeiss S, Clarke L, Helm K. Age distribution of biopsied junctional nevi. J. Am. Acad. Dermatol. 56, 825-827 (2007).
21. National Institutes of Health Consensus Development Panelon Early Melanoma. Diagnosis and treatment of early melanoma. JAMA 268, 1314-1319 (1992).
22. Halpern AC, Guerry D 4th, Elder DE, Trock B, Synnestvedt M, Humphreys T. Natural history of dysplastic nevi. J. Am. Acad. Dermatol. 40, 51-57 (1993).
23. Haley JC, Hood AF, Chuang TY, Rasmussen J. The frequency of histologically dysplastic nevi in 199 pediatric patients. Pediatr. Dermatol. 17, 266-269 (2000).
24. Schaffer JV. Pigmented lesions in children: when to worry. Curr. Opin. Pediatr. 19, 430-440 (2007).
25. Tsao H, Bevona C, Goggins W, Quinn T. The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate. Arch. Dermatol. 139, 282-288 (2003).
26. Bauer J, Garbe C. Acquired melanocytic nevi as risk factor for melanoma development: a comprehensive review of epidemiological data. Pigment Cell Res. 16, 297-306 (2003).
27. Bauer J, Garbe C. Risk estimation for malignant transformation of melanocytic nevi. Arch. Dermatol. 140, 127 (2004).
28. Pizzichetta MA, Massone C, Grandi G, Pelizzo G, Soyer HP. Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy. Arch. Dermatol. 142, 479-483 (2006).
29. Gonzalez-Campora R, Galera-Davidson H, Vazquez-Ramirez FJ, Diaz-Cano S. Blue nevus: classical types and new related entities. A differential diagnostic review. Pathol. Res. Prac. 190, 627-635 (1994).
30. Granter SR, McKee PH, Calonje E, Mihm MC Jr, Busam K. Melanoma associated with blue nevus and melanoma mimicking cellular blue nevus: a clinicopathologic study of 10 cases on the spectrum of so called 'malignant blue nevus'. Am. J. Surg. Pathol. 25, 316-323 (2001).
31. Tran TA, Carlson JA, Basaca PC, Mihm MC. Cellular blue nevus with atypia (atypical cellular blue nevus): a clinicopathologic study of nine cases. J. Cutan. Pathol. 25, 252-258 (1998).
32. Ferrara G, Soyer HP, Malvehy J et al. The many faces of blue nevus: a clinicopathologic study. J. Cutan. Pathol. 34, 543-551 (2007).
33. Hocevar M, Kitanovski L, Frkovic Grazio S. Malignant blue nevus with lymph node metastases in five-year old girl. Croat. Med. J. 46, 463-466 (2005).
34. Popovic M, Dolenc-Strazar Z, Anzic J, Luzar B. Childhood malignant blue nevus of the ear associated with two intracranial melanocytic tumors - metastases or neurocutaneous melanosis? Hum. Pathol. 35(2), 1292-1296 (2004).
35. Scott GA, Trepeta R. Clear cell sarcoma of tendons and aponeuroses and malignant blue nevus arising in prepubescent children. Report of two cases and review of the literature. Am. J. Dermatopathol. 15, 139-145 (1993).
36. Djawari D, Cremer H. [Malignant blue nevus]. Z. Hautkr. 64, 51-53 (1989).
37. Gartmann H, Muller HD. Combined occurrence of blue nevus and nevus cell nevus in one and the same tumor ('combined nevus'). Z. Hautkr. 52, 389-398 (1977).
38. De Giorgi V, Massi D, Salvini C, Trez E, Mannone F, Carli P. Dermoscopic features of combined melanocytic nevi. J. Cutan. Pathol. 31, 600-604 (2004).
39. Sutton RL. An unusual variety of vitiligo (leucoderma acquisitum centrifugum). J. Cut. Dis. 34, 797-800 (1926).
40. Kopf AW, Morril SD, Silberberg I. Broad spectrum of leukoderma acquisitum centrifugum. Arch. Dermatol. 92, 14-35 (1965).
41. Leow LJ, Goh BK. Halo congenital naevus in a middle aged patient with vitiligo. Australas. J. Dermatol. 49 (4), 229-232 (2008).
42. Brazzelli V, Larizza D, Martinetti M et al. Halo nevus, rather than vitiligo, is a typical dermatologic finding of Turner's syndrome: clinical, genetical, and immunogenetic study in 42 patients. J. Am. Acad. Dermatol. 51 (3), 354-358 (2004).
43. Mooney MA, Barr RJ, Buxton MG. Halo nevus or halo phenomenon? A study of 142 cases. J. Cutan. Pathol. 22, 342-348 (1995).
44. Akasu R, From L, Kahn HJ. Characterization of the mononuclear infiltrate involved in regression of halo nevi. J. Cutan. Pathol. 21, 302-311 (1994).
45. Harvell JD, Meehan SA, LeBoit PE. Spitz's nevi with halo reaction: a histopathologic study of 17 cases. J. Cutan. Pathol. 24, 611-619 (1997).
46. Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J. Am. Acad. Dermatol. 37, 620-624 (1997).
47. Kolm I, Di Stefani A, Hofmann-Wellenhof R et al. Dermoscopy patterns of halo nevi. Arch. Dermatol. 142(12), 1627-1632 (2006).
48. Zalaudek I, Moscarella E, Argenziano G. Artifactual "pseudo-halo nevi" secondary to sunscreen application. J. Am. Acad. Dermatol. 54, 1106-1107 (2006).
49. Schaffer JV, Orlow SJ, Lazova R, Bolognia JL. Speckled lentiginous nevus - classic congenital melanocytic nevus hybrid not the result of "collision". Arch. Dermatol. 137, 1655 (2001).
50. Cramer SF. Speckled lentiginous nevus (nevus spilus): the "roots" of the "melanocytic garden". Arch. Dermatol. 137, 1654-1655 (2001).
51. Cohen LM. Nevus spilus: congenital or acquired? Arch. Dermatol. 137, 215-216 (2001).
52. Schaffer JV, Orlow SJ, Lazova R, Bolognia JL. Speckled lentiginous nevus: within the spectrum of congenital melanocytic nevi. Arch. Dermatol. 137, 172-178 (2001).
53. Calista D. Spitz naevus arising within congenital naevus spilus. J. Eur. Acad. Dermatol. Venereol. 19, 137-138 (2005).
54. Falo LD Jr, Sober AJ, Barnhill RL. Evolution of a naevus spilus. Dermatology 189, 382-383 (1994).
55. Abecassis S, Spatz A, Cazeneuve C et al. Melanoma within naevus spilus: 5 cases. Ann. Dermatol. Venereol. 133, 323-328 (2006).
56. Marghoob AA, Blum R, Nossa R, Busam KJ, Sachs D, Halpern A. Agminated atypical (dysplastic) nevi: case report and review of the literature Arch. Dermatol. 137, 917-920 (2001).
57. Bragg JW, Swindle L, Halpern AC, Marghoob AA. Agminated acquired melanocytic nevi of the common and dysplastic type. J. Am. Acad. Dermatol. 52, 67-73 (2005).
58. Tomasini C, Broganelli P, Pippione M. Targetoid hemosiderotic nevus. A trauma-induced simulator of malignant melanoma. Dermatology 210, 200-205 (2005).
59. Tronnier M, Alexander M, Neitmann M, Brinckmann J, Wolff HH. Morphological changes in melanocytic nevi induced by exogenous factors. Hautarzt 51, 561-566 (2000).
60. Santa Cruz D, Aronberg J. Targetoid hemosiderotic hemangioma. J. Am. Acad. Dermatol. 19, 550-558 (1988).
61. Guillon L, Calonje E, Speight P, Rosai J, Fletcher CDM. Hobnail hemangioma. A pseudomalignant vascular lesion with a reappraisal of targetoid hemosiderotic hemangioma. Am. J. Surg. Pathol. 23, 97-105 (1999).
62. Krengel S, Haushild A, Schafer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br. J. Dermatol. 155 (1), 1-8 (2006).
63. Bett BJ. Large or multiple congenital melanocytic nevi: occurrence of neurocutaneous melanocytosis in 1008 persons. J. Am. Acad. Dermatol. 54, 767-777 (2006)
64. Kadonaga JN, Frieden IJ. Neurocutaneous melanosis: definition and review of the literature. J. Am. Acad. Dermatol. 24, 747-755 (1991).
65. Foster RD, Williams ML, Barkovich AJ et al. Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic children. Plast. Reconstr. Surg. 107, 933-941 (2001).
66. Humphreys RP. Clinical evaluation of cutaneous lesions of the back: spinal signatures that do not go away. Clin. Neurosurg. 43, 175-187 (1996).
67. Tannous ZS, Mihm MC, Sober AJ et al. Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management. J. Am. Acad. Dermatol. 52, 197-203 (2005).
68. Makkar HS, Frieden IJ. Congenital melanocytic nevi: an update for the pediatrician. Curr. Opin. Pediatr. 14, 397-403 (2002).
69. Bohn J, Svensson H, Aberg M. Dermosbrasion of large congenital melanocytic naevi in neonates. Scand. J. Plast. Reconstr. Surg. Hand. Surg. 34, 321-326 (2000).
70. DeRaeve LE, Roseeuw DI. Curettage of giant congenital melanocytic nevi in neonates. A decade later. Arch. Dermatol. 138, 943-947 (2002).
71. Hopkins JD, Smith AW, Jackson IT. Adjunctive treatment of congenital pigmented nevi with phenol chemical peel. Plast. Reconstruct. Surg. 105(1), 1-11 (2000).
72. Waldorf HA, Kauvar ANB, Geronemus RG. Treatment of small and medium congenital nevi with the Q-switched ruby laser. Arch. Dermatol. 132, 301-304. (1996).
73. Spitz S. Melanomas of childhood. Am. J. Pathol. 24, 591-609 (1948).
74. Kopf AW, Andrade R. Benign juvenile melanoma. In: Year Book of Dermatology III. Kopf AW, Andrade R (Eds). Year Book Medical Publisher Inc., IL, USA 7-52 (1966).
75. Weedon D, Little JH. Spindle and epithelioid cell nevi in children and adults: a review of 211 cases of the Spitz nevus. Cancer 40, 217-225 (1977).
76. Gartmann H, Ganser M. Der Spitz-Nevus, Spindelzellen und/oder Epitheloidzellennevus: eine klinische analyse von 652 tumoren. Z. Hautkr. 60, 22-28 (1985).
77. Weedon D. Lentigines, nevi and melanomas. In: Skin Pathology (2nd Edition). Weedon D (Ed.). Churchill Livingstone, Edinburgh, UK 803-858 (2002).
78. Reed RJ, Ichinose H, Clark WH et al. Common and uncommon melanocytic nevi and borderline melanomas. Semin. Oncol. 2, 119-147 (1975).
79. Paniago-Pereira C, Maize JC, Ackerman AB. Nevus of large spindle and/or epithelioid cell (Spitz's nevus). Arch. Dermatol. 112, 1811-1823 (1978).
80. Kolde G, Vakilzadeh F. Der pigmentierte Spindelzellentumor. Hautarzt 38, 743-745 (1987).
81. Smith NP. The pigmented spindle cell tumor of Reed: an underdiagnosed lesion. Semin. Diagn. Pathol. 4, 75-87(1987).
82. Barnhill RL, Mihm MC Jr. Pigmented spindle cell nevus and its variants distinction from melanoma. Br. J. Dermatol. 121, 717-726 (1989).
83. Barnhill RL, Barnhill MA, Berwick M, Mihm MC Jr. The histologic spectrum of pigmented spindle cell nevus: a review of 120 cases with emphasis on atypical variants. Hum. Pathol. 22, 53-58 (1991).
84. Barnhill RL, Mihm MC Jr, Magro CM. Plexiform spindle cell nevus: a distinctive variant of plexiform melanocytic nevus. Histopathology 18, 243-247 (1991).
85. Grossin M. Reed's nevus. Ann. Dermatol. Venereol. 119, 145 (1992).
86. Sau P, Graham JH, Helwig EB. Pigmented spindle cell nevus: a clinicopathologic analysis of ninety-five cases. J. Am. Acad. Dermatol. 28, 565-571 (1993).
87. Ferrara G, Argenziano G, Soyer HP et al. The spectrum of Spitz nevi: a clinico pathologic study of 83 cases. Arch. Dermatol. 141, 1381-1387 (2005).
88. Smith K, Skelton H, Lupton G, Graham J. Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus). Am. J. Surg. Pathol. 13, 931-939 (1989).
89. Barnhill RL, Argenyi ZB, From L et al. Atypical Spitz nevi/tumor: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum. Pathol. 30, 513-520 (1999).
90. Barnhill RL. The Spitzoid lesion: the importance of atypical variants and risk assessment. Am. J. Dermatopathol. 28, 75-83 (2006).
91. Cerroni L. A new perspective for Spitz tumors? Am. J. Dermatopathol. 27, 366-367 (2005).
92. Peris K, Ferrari A, Argenziano G et al. Dermoscopic classification of Spitz/Reed nevi. Clin. Dermatol. 20, 259-262 (2002).
93. Pizzichetta MA, Argenziano G, Grandi G et al. Morphologic changes of a pigmented Spitz nevus assesed by dermoscopy. J. Am. Acad. Dermatol. 47, 137-139 (2002).
94. Argenziano G, Zalaudek I, Corona R et al. Vascular structures in skin tumors: a dermoscopy study. Arch. Dermatol. 140, 1485-1489 (2004).
95. Argenziano G, Soyer HP, Ferrara G et al. Superficial black network: an additional dermoscopic clue for the diagnosis of spinale and/ or epithelioid cell nevus. Dermatology 203, 333-335 (2001).
96. Argenziano G, Zalaudek I, Ferrara G et al. Involution: the natural evolution of pigmented Spitz and Reed nevi? Arch. Dermatol. 143, 549-551 (2007).
97. Urso C. A new perspective for Spitz tumors? Am. J. Dermatopathol. 27, 364-365 (2005).
98. Argenziano G, Scalvenzi M, Staibano S et al. Dermatoscopic pitfalls in differentiating pigmented Spitz nevi from cutaneous melanomas. Br. J. Dermatol. 141, 788-793 (1999).
99. Brunetti B, Nino M, Sammarco E, Scalvenzi M. Spitz naevus: a proposal for management. J. Eur. Acad. Dermatol. Venereol. 19, 391(2005).
100. Zalaudek I, Sgambato A, Ferrara G, Argenziano G. Diagnosis and managment of melanocytic skin lesions in the pediatric praxis. Minerva Pediatr. 60, 291-312 (2008).
101. Kelley SW, Cockerell CJ. Sentinel lymph node biopsy as an adjunct to management of histologically difficult to diagnose melanocytic lesions: a proposal. J. Am. Acad. Dermatol. 42, 527-530 (2000).
102. Lohmann CM, Coit DG, Brady MS et al. Sentinel lymph node biopsy in patients with diagnostically controversial Spitzoid melanocytic tumors. Am. J. Surg. Pathol. 26, 47-55 (2002).
103. Su LD, Fullen DR, Sondak VK et al. Sentinel lymph biopsy for patients with problematic Spitzoid melanocytic lesions: a report on 18 patients. Cancer 97, 499-507 (2003).
104. Gamblin TC, Edington H, Kirkwood JM et al. Sentinel lymph node biopsy for atypical melanocytic lesions with Spitzoid features. Ann. Surg. Oncol. 13, 1664-1670 (2006).
105. Urso C, Borgognoni L, Saieva C et al. Sentinel lymph node biopsy in patients with "atypical Spitz tumors". A report on 12 cases. Hum. Pathol. 37, 816-823 (2006).
106. Murali R, Sharma RN, Thomson JF et al. Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with Spitzoid features (so called atypical Spitzoid tumors). Ann. Surg. Oncol. 15, 302-309 (2008).
107. Busam KJ, Pulitzer M. Sentinel lymph node biopsy for patients with diagnostically controversial Spitzoid melanocytic tumors? Adv. Anat. Pathol. 15(5), 253-262 (2008).
108. Bastian BC, LeBoit PE, Hamm H et al. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res. 58, 2170-2175 (1998).
109. Bastian BC, Wesselmann U, Pinkel D et al. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J. Invest. Dermatol. 113, 1065-1069 (1999).
110. Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am. J. Pathol. 157, 967-972 (2000).
111. Curtin JA, Fridlyand J, Kageshita T et al. Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353, 2135-2147 (2005).
112. van Dijk MC, Rombout PD, Mooi WJ et al. Allelic imbalance in the diagnosis of benign, atypical and malignant Spitz tumours. J. Pathol. 197, 170-178 (2002).
113. van Dijk MC, Bernsen MR, Ruiter DJ. Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and Spitzoid melanoma. Am. J. Surg. Pathol. 29, 1145-1151 (2005).
114. Healy E, Belgaid CE, Takata M et al. Allelotypes of primary cutaneous melanoma and benign melanocytic nevi. Cancer Res. 56, 589-593 (1996).
115. Takata M, Suzuki T, Ansai S et al. Genome profiling of melanocytic tumors using multiplex ligation-dependent probe amplification (MLPA): its usefulness as an adjunctive diagnostic tool for melanocytic tumors. J. Dermatol. Sci. 40, 51-57 (2005).
116. Curtin JA, Busam K, Pinkel D et al. Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 24, 4340-4346 (2006).
117. Lee DA, Cohen JA, Twaddell WS et al. Are all melanomas the same? Spitzoid melanoma is a distinct subtype of melanoma. Cancer 106, 907-913 (2006).
118. Gill M, Cohen J, Renwick N et al. Genetic similarities between Spitz nevus and Spitzoid melanoma in children. Cancer 101, 2636-2640 (2004).
119. Takata M, Lin J, Takayanagi S, Suzuki T et al. Genetic and epigenetic alterations in the differential diagnosis of malignant melanoma and Spitzoid lesion. Br. J. Dermatol. 156(6), 1287-1294 (2007).
120. Karlsson P, Boeryd B, Sander E et al Increasing incidence of cutaneous malignant melanoma in children and adolescents 12-19 years of age in Sweden 1973-1992. Acta Derm. Venereol. 78, 289-292 (1998).
121. Strouse JJ, Fears TR, Tucker MA et al. Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database. J. Clin. Oncol. 23, 4735-4741 (2005).
122. Lewis KG. Trends in pediatric melanoma mortality in the United States, 1968 through 2004. Dermatol. Surg. 34, 152-159 (2004).
123. Livestro DP, Kaine EM, Michaelson JS et al. Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis. Cancer 110, 614-624 (2007).
124. Bütter A, Hui T, Chapdelaine J, Beaunoyer M, Flageole H, Bouchard S. Melanoma in children and the use of sentinel lymph node biopsy. J. Pediatr. Surg. 40, 797-800 (2005).
125. Pol-Rodriquez M, Lee S, Silvers DN, Celebi JT. Influence of age on survival in childhood Spitzoid melanomas. Cancer 109, 1579-1583 (2007).
126. Clark WH, Elder DE, Guerry D. Displastic nevi and malignant melanoma. In: Pathology of the Skin (1st Edition). Farmer ER, Hood AF (Eds). McGraw Hill, OH, USA 729-735 (1996).
127. Bastian BC, Xiong J, Frieden I et al. Genetic changes in neoplasms arising in congenital melanocytic nevi. Am. J. Pathol. 161, 1163-1169 (2002).