Pigmented lesions in children: When to worry

Current Opinion in Pediatrics

Volumn 19, Issue 4, 2007, Pages 430-440

  Schaffer, Julie V ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atypical nevi; Congenital melanocytic nevi; Melanocytic nevi; Melanoma; Spitz nevi

Indexed keywords

ACRAL NEVUS; AFRICAN AMERICAN; AGE DISTRIBUTION; AMERICAN INDIAN; ASIAN; BLUE NEVUS; CANCER RISK; CANCER SUSCEPTIBILITY; CARBON DIOXIDE LASER; CAUCASIAN; CHILDHOOD CANCER; CONGENITAL NEVUS; DEPIGMENTATION; DERMOEPIDERMAL JUNCTION; DIFFERENTIAL DIAGNOSIS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPILUMINESCENCE MICROSCOPY; ERBIUM YAG LASER; FAMILIAL ATYPICAL MULTIPLE MOLE MELANOMA SYNDROME; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HALO NEVUS; HEREDITY; HUMAN; JUVENILE MELANOMA; MELANOCYTIC NEVUS; MELANOMA; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PREPUBERTY; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; RISK ASSESSMENT; SKIN ABRASION; SKIN EXAMINATION; SKIN PIGMENTATION; SKIN PROTECTION; SKIN SURGERY; SKIN TRANSPLANTATION; SOCIAL PSYCHOLOGY; SUN EXPOSURE;

CHILD; DIAGNOSIS, DIFFERENTIAL; HUMANS; MELANOMA; NEVUS, BLUE; NEVUS, EPITHELIOID AND SPINDLE CELL; NEVUS, PIGMENTED; SKIN NEOPLASMS;

EID: 34447530317     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e32825b0788     Document Type: Review

References (100)

1. Strouse JJ, Fears TR, Tucker MA, Wayne AS. Pediatric melanoma: risk factor and survival analysis of the Surveillance, Epidemiology and End Results Database. J Clin Oncol 2005; 23:4735-4741.
2. Ries LAG, Melbert D, Krapcho M, et al. SEER cancer statistics review, 1975-2004. Bethesda, Maryland: National Cancer Institute; 2007. http://seer.cancer.gov/csr/1975_2004/, based on November 2006 SEER data submission. [Accessed 25 April 2007] Recently updated statistics regarding the epidemiology of melanoma and other cancers in the United States; a summary of melanoma statistics is also available at http://www.seer.cancer.gov/statfacts/ html/melan.html.
3. Huynh PM, Grant-Kels JM, Grin CM. Childhood melanoma: update and treatment. Int J Dermatol 2005; 44:715-723.
4. Dulon M, Weichenthal M, Blettner M, et al. Sun exposure and number of nevi in 5- to 6-year-old European children. J Clin Epidemiol 2002; 55:1075-1081.
5. Prok LD, Arbuckle HA. Nevi in children: a practical approach to evaluation. Pediatr Ann 2007; 36:39-45.
6. Valiukeviciene S, Miseviciene I, Gollnick H. The prevalence of common acquired melanocytic nevi and the relationship with skin type characteristics and sun exposure among children in Lithuania. Arch Dermatol 2005; 141:579-586.
7. Whiteman DC, Brown RM, Purdie DM, Hughes MC. Melanocytic nevi in very young children: the role of phenotype, sun exposure, and sun protection. J Am Acad Dermatol 2005; 52:40-47.
8. Siskind V, Darlington S, Green L, Green A. Evolution of melanocytic nevi on the faces and necks of adolescents: a 4 y longitudinal study. J Invest Dermatol 2002; 118:500-504.
9. LaVigne EA, Oliveria SA, Dusza SW, et al. Clinical and dermoscopic changes in common melanocytic nevi in school children: the Framingham School Nevus Study. Dermatology 2005; 211:234-239.
10. Zalaudek I, Grinschgl, Argenziano G, et al. Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi. Br J Dermatol 2006; 154:299-304.
11. Zalaudek I, Hofmann-Wellenhof R, Soyer HP, et al. Naevogenesis: new thoughts based on dermoscopy. Br J Dermatol 2006; 154:774-807.
12. Schaffer JV, Bolognia JL. The biology of melanocytic nevi. In: Nordlund JJ, Boissy RE, Hearing VJ, et al., editors. The pigmentary system: physiology and pathophysiology, 2nd ed. Oxford, UK: Blackwell Publishing; 2006. pp. 1092-1125.
13. MacLennan R, Kelly JW, Rivers JK, Harrison SL. The Eastern Australian Childhood Nevus Study: site differences in density and size of melanocytic nevi in relation to latitude and phenotype. J Am Acad Dermatol 2003; 48:367-375.
14. Synnerstad I, Nilsson L, Fredrikson M, Rosdahl I. Frequency and distribution pattern of melanocytic naevi in Swedish 8-9-year-old children. Acta Derm Venereol 2004; 84:271-276.
15. Gefeller O, Tarantino J, Lederer P, et al. The relation between patterns of vacation sun exposure and the development of acquired melanocytic nevi in German children 6-7 years of age. Am J Epidemiol 2007; 3 March [Epub ahead of print].
16. Wiecker TS, Luther H, Buettner P, et al. Moderate sun exposure and nevus counts in parents are associated with development of melanocytic nevi in childhood: a risk factor study in 1,812 kindergarten children. Cancer 2003; 97:628-638.
17. Bauer J, Buttner P, Wiecker TS, et al. Risk factors of incident melanocytic nevi: a longitudinal study in a cohort of 1,232 young German children. Int J Cancer 2005; 115:121-126.
18. Wachsmuth RC, Turner F, Barrett JH, et al. The effect of sun exposure in determining nevus density in UK adolescent twins. J Invest Dermatol 2005; 124:56-62.
19. English DR, Milne E, Simpson JA. Ultraviolet radiation at places of residence and the development of melanocytic nevi in children (Australia). Cancer Causes Control 2006; 17:103-107.
20. Cockburn M, Hamilton A, Mack T. The simultaneous assessment of constitutional, behavioral, and environmental factors in the development of large nevi. Cancer Epidemiol Biomarkers Prev 2007; 16:200-206.
21. Rodvall Y, Wahlgren CF, Ullen H, Wiklund K. Common melanocytic nevi in 7-year-old schoolchildren residing at different latitudes in Sweden. Cancer Epidemiol Biomarkers Prev 2007; 16:122-127.
22. Matichard E, Le Hénanff A, Sanders A, et al. Effect of neonatal phototherapy on melanocytic nevus count in children. Arch Dermatol 2006; 142:1599-1604.
23. Lebeau S, Braun RP, Masouye I, et al. Acquired melanocytic naevus in childhood vulval pemphigoid. Dermatology 2006; 213:159-162.
24. Gallardo F, Toll A, Malvehy J, et al. Large atypical melanocytic nevi in recessive dystrophic epidermolysis bullosa: clinicopathological, ultrastructural, and dermoscopic study. Pediatr Dermatol 2005; 22:338-343.
25. Bovenschen HJ, Tjioe M, Vermaat H, et al. Induction of eruptive benign melanocytic naevi by immune suppressive agents, including biologicals. Br J Dermatol 2006; 154:880-884.
26. Uter WJ, Pfahlberg AB, Gefeller O. Nevus density and atopic eczema. Arch Dermatol 2005; 141:101-102.
27. Dellavalle RP, Johnson KR, Hester EJ, et al. Children with red hair have more freckles but fewer melanocytic nevi: results from a cohort study of 280 three-year-olds. Arch Dermatol 2005; 141:1042-1043.
28. Oliveria SA, Saraiya M, Geller AC, et al. Sun exposure and risk of melanoma. Arch Dis Child 2006; 91:131-138. Comprehensive review of epidemiologic evidence on the relationship between sun exposure during childhood and adolescence and risk of developing melanoma during adulthood.
29. Lee TK, Rivers JK, Gallagher RP. Site-specific protective effect of broad-spectrum sunscreen on nevus development among white schoolchildren in a randomized trial. J Am Acad Dermatol 2005; 52:786-792.
30. Bauer J, Buttner P, Wiecker TS, et al. Effect of sunscreen and clothing on the number of melanocytic nevi in 1,812 German children attending a day care. Am J Epidemiol 2005; 161:620-627.
31. English DR, Milne E, Simpson JA. Sun protection and the development of melanocytic nevi in children. Cancer Epidemiol Biomarkers Prev 2005; 14:2873-2876.
32. Autier P, Doré JF, Cattaruzza MS, et al. Sunscreen use, wearing clothes, and number of nevi in 6- to 7-year-old European children. J Natl Cancer Inst 1998; 90:1873-1880.
33. Jaramillo-Ayerbe F, Vallejo-Contreras J. Frequency and clinical and dermatoscopic features of volar and ungual pigmented melanocytic lesions: a study in schoolchildren of Manizales, Colombia. Pediatr Dermatol 2004; 21:218-222.
34. Goettmann-Bonvallot S, Andre J, Belaich S. Longitudinal melanonychia in children: a clinical and histopathologic study of 40 cases. J Am Acad Dermatol 1999; 41:17-22.
35. National Institutes of Health Consensus Development Panel on Early Melanoma. Diagnosis and treatment of early melanoma. JAMA 1992; 268:1314-1319.
36. Florell SR, Meyer LJ, Boucher KM, et al. Longitudinal assessment of the nevus phenotype in a melanoma kindred. J Invest Dermatol 2004; 123:576-582.
37. Slade J, Marghoob AA, Salopek TG, et al. Atypical mole syndrome: risk factor for cutaneous malignant melanoma and implications for management. J Am Acad Dermatol 1995; 32:479-494.
38. Pho L, Grossman D, Leachman SA. Melanoma genetics: a review of genetic factors and clinical phenotypes in familial melanoma. Curr Opin Oncol 2006; 18:173-179.
39. Bishop JN, Harland M, Randerson-Moor J, Bishop DT. Management of familial melanoma. Lancet Oncol 2007; 8:46-54. Review of familial melanoma risk attributable to both high-penetrance (e.g. CDKN2A) and lower-penetrance (MC1R) genes and shared environment, as well as approaches to managing melanoma families.
40. Schaffer JV, Glusac EJ, Bolognia JL. The eclipse naevus: tan centre with stellate brown rim. Br J Dermatol 2001; 145:1023-1026.
41. Yazici AC, Ikizoglu G, Apa DD, et al. The eclipse naevus and cockade naevus: are they two of a kind? Clin Exp Dermatol 2006; 31:596-597.
42. Bolognia JL. Too many moles. Arch Dermatol 2006; 142:508. Approach to the clinical evaluation of the 'moley' patient, including recognition of the signature nevus.
43. McGregor B, Pfizner J, Zhu G, et al. Genetic and environmental contributions to size, color, shape, and other characteristics of melanocytic naevi in a sample of adolescent twins. Genet Epidemiol 1999; 16:40-53.
44. Gandini S, Sera F, Cattaruzza MS, et al. Meta-analysis of risk factors for cutaneous melanoma. I: Common and atypical naevi. Eur J Cancer 2005; 41:28-44.
45. Tsao H, Bevona C, Goggins W, Quinn T. The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate. Arch Dermatol 2003; 139:282-288.
46. Grob JJ. The 'ugly duckling' sign: identification of the common characteristics of nevi in an individual as a basis for melanoma screening. Arch Dermatol 1998; 134:103-104.
47. Salopek TG. The dilemma of the dysplastic nevus. Dermatol Clin 2002; 20:617-628.
48. Makkar HS, Frieden IJ. Congenital melanocytic nevi: an update for the pediatrician. Curr Opin Pediatr 2002; 14:397-403.
49. Marghoob AA, Schoenbach SP, Kopf AW, et al. Large congenital melanocytic nevi and the risk for the development of malignant melanoma: a prospective study. Arch Dermatol 1996; 132:170-175.
50. Ingordo V, Gentile C, Iannazzone SS, et al. Congenital melanocytic nevus: an epidemiologic study in Italy. Dermatology 2007; 214:227-230.
51. Krengel S, Hauschild A, Schäfer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol 2006; 155:1-8. Review of published studies on the melanoma risk associated with congenital melanocytic nevi. Inconsistent documentation of the size, location and treatments of the nevi as well as the patients' ages and follow-up time in the studies upon which the review was based limits the conclusions that can be drawn.
52. Kanzler MH. Management of large congenital melanocytic nevi: art versus science. J Am Acad Dermatol 2006; 54:874-876.
53. Marghoob AA, Agero AL, Benvenuto-Andrade C, Dusza SW. Large congenital melanocytic nevi, risk of cutaneous melanoma, and prophylactic surgery. J Am Acad Dermatol 2006; 54:868-870.
54. Ruiz-Maldonado R, Tamayo L, Laterza AM, Durán C. Giant pigmented nevi: clinical, histopathologic, and therapeutic considerations. J Pediatr 1992; 120:906-911.
55. Egan CL, Oliveria SA, Elenitsas R, et al. Cutaneous melanoma risk and phenotypic changes in large congenital nevi: a follow-up study of 46 patients. J Am Acad Dermatol 1998; 39:923-932.
56. Hale EK, Stein J, Ben-Porat L, et al. Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi: results from the NYU-LCMN registry. Br J Dermatol 2005; 152:512-517.
57. Bett BJ. Large or multiple congenital melanocytic nevi: occurrence of cutaneous melanoma in 1008 persons. J Am Acad Dermatol 2005; 52:793-797.
58. Ka VS, Dusza SW, Halpern AC, Marghoob AA. The association between large congenital melanocytic naevi and cutaneous melanoma: preliminary findings from an Internet-based registry of 379 patients. Melanoma Res 2005; 15:61-67.
59. Sahin S, Levin L, Kopf AW, et al. Risk of melanoma in medium-sized congenital melanocytic nevi: a follow-up study. J Am Acad Dermatol 1998; 39:428-433.
60. Swerdlow AJ, English JS, Qiao Z. The risk of melanoma in patients with congenital nevi: a cohort study. J Am Acad Dermatol 1995; 32:595-599.
61. Dawson HA, Atherton DJ, Mayou B. A prospective study of congenital melanocytic naevi: progress report and evaluation after 6 years. Br J Dermatol 1996; 134:617-623.
62. Berg P, Lindelöf B. Congenital melanocytic naevi and cutaneous melanoma. Melanoma Res 2003; 13:441-445.
63. Zaal LH, Mooi WJ, Klip H, et al. Risk of malignant transformation of congenital melanocytic nevi: a retrospective nationwide study from the Netherlands. Plast Reconstr Surg 2005; 116:1902-1909.
64. Gruson LM, Orlow SJ, Schaffer JV. Phacomatosis pigmentokeratotica associated with hemihypertrophy and a rhabdomyosarcoma of the abdominal wall. J Am Acad Dermatol 2006; 55:S16-S20.
65. Bae JM, Kim MY, Kim HO, Park YM. Schwannoma coexisting with giant congenital melanocytic nevus: is it coincidence? J Am Acad Dermatol 2007; 56:S111-S112.
66. Marghoob AA, Dusza S, Oliveria S, Halpern AC. Number of satellite nevi as a correlate for neurocutaneous melanocytosis in patients with large congenital melanocytic nevi. Arch Dermatol 2004; 140:171-175.
67. Agero AL, Benvenuto-Andrade C, Dusza SW, et al. Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: a study of cases from an Internet-based registry. J Am Acad Dermatol 2005; 53:959-965.
68. Bett BJ. Large or multiple congenital melanocytic nevi: occurrence of neurocutaneous melanocytosis in 1008 persons. J Am Acad Dermatol 2006; 54:767-777.
69. Foster RD, Williams ML, Barkovich AJ, et al. Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic children. Plast Reconstr Surg 2001; 107:933-941.
70. Tannous ZS, Mihm MC, Sober AJ, Duncan LM. Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical management. J Am Acad Dermatol 2005; 52:197-203.
71. Tromberg J, Bauer B, Benvenuto-Adrade C, Marghoob AA. Congenital nevi needing treatment. Dermatol Ther 2005; 18:136-150.
72. Bauer BS, Corcoran J. Treatment of large and giant nevi. Clin Plastic Surg 2005; 32:11-18.
73. Koot HM, de Waard-van der Spek F, Peer CD, et al. Psychosocial sequelae in 29 children with giant congenital melanocytic naevi. Clin Exp Dermatol 2000; 25:589-593.
74. Leech SN, Bell H, Leonard N, Jones SL, et al. Neonatal giant congenital nevi with proliferative nodules: a clinicopathologic study and literature review of neonatal melanoma. Arch Dermatol 2004; 140:83-88.
75. McGowan JW, Smith MK, Ryan M, Hood AF. Proliferative nodules with balloon-cell change in a large congenital melanocytic nevus. J Cutan Pathol 2006; 33:253-255.
76. Rajpar SF, Abdullah A, Lanigan SW. Er :YAG laser resurfacing for inoperable medium-sized facial congenital melanocytic naevi in children. Clin Exp Dermatol 2007; 32:159-161.
77. Menon K, Dusza SW, Marghoob AA, et al. Classification and prevalence of pigmented lesions in patients with total-body photographs at high risk of developing melanoma. J Cutan Med Surg 2006; 10:85-91.
78. Schaffer JV, Orlow SJ, Lazova R, Bolognia JL. Speckled lentiginous nevus: within the spectrum of congenital melanocytic nevi. Arch Dermatol 2001; 137:172-178.
79. Vidaurri-de la Cruz H, Happle R. Two distinct types of speckled lentiginous nevi characterized by macular versus papular speckles. Dermatology 2006; 212:53-58.
80. Kolm I, Di Stefani A, Hofmann-Wellenhof R, et al. Dermoscopy patterns of halo nevi. Arch Dermatol 2006; 142:1627-1632.
81. Patrizi A, Neri I, Sabattini E, et al. Unusual inflammatory and hyperkeratotic halo naevus in children. Br J Dermatol 2005; 152:357-360.
82. Ashrafi MR, Shabanian R, Mohammadi M, Kavusi S. Extensive Mongolian spots: a clinical sign merits special attention. Pediatr Neurol 2006; 34:143-145.
83. Zembowicz A, Mihm MC. Dermal dendritic melanocytic proliferations: an update. Histopathology 2004; 45:433-451.
84. Boikos SA, Stratakis CA. Carney complex: the first 20 years. Curr Opin Oncol 2007; 19:24-29.
85. Bittencourt AL, Monteiro DA, De Pretto OJ. Infiltrating giant cellular blue nevus. J Clin Pathol 2007; 60:82-84.
86. Morgan CJ, Nyak N, Cooper A, et al. Multiple Spitz naevi: a report of both variants with clinical and histopathological correlation. Clin Exp Dermatol 2006; 31:368-371.
87. Argenziano G, Zalaudek I, Ferrara G, et al. Involution: the natural evolution of pigmented Spitz and Reed nevi? Arch Dermatol 2007; 143:549-551.
88. Gelbard SN, Tripp JM, Marghoob AA, et al. Management of Spitz nevi: a survey of dermatologists in the United States. J Am Acad Dermatol 2002; 47:224-230.
89. Shapiro PE. Spitz nevi. J Am Acad Dermatol 1993; 29:667-668.
90. LeBoit PE. 'Safe' Spitz and its alternatives. Pediatr Dermatol 2002; 19:163-165.
91. Brunetti B, Nino M, Sammarco E, Scalvenzi M. Spitz naevus: a proposal for management. JEADV 2005; 19:391-393.
92. Mooi WJ, Krausz T. Spitz nevus versus Spitzoid melanoma: diagnostic difficulties, conceptual controversies. Adv Anat Pathol 2006; 13:147-156.
93. Barnhill RL. The Spitzoid lesion: rethinking Spitz tumors, atypical variants, Spitzoid melanoma and risk assessment. Mod Pathol 2006; 19:S21-S33. Discussion of current concepts and controversies regarding Spitz nevi and other Spitzoid neoplasms.
94. Lange JR, Balch CM. Melanoma in children: heightened awareness of an uncommon but often curable malignancy. Pediatrics 2005; 115:802-803.
95. Ferrari A, Bono A, Baldi M, et al. Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution. Pediatrics 2005; 115:649-654.
96. Roaten JB, Partrick DA, Bensard D, et al. Survival in sentinel lymph nodepositive pediatric melanoma. J Pediatr Surg 2005; 40:988-992.
97. Gamblin TC, Edington H, Kirkwood JM, Rao UN. Sentinel lymph node biopsy for atypical melanocytic nevi with spitzoid features. Ann Surg Oncol 2006; 13:1664-1670.
98. Wick MR. Melanocytic lesions with features of Spitz nevus. Hum Pathol 2006; 37:779-780.
99. Leman JA, Evans A, Mooi W, MacKie RM. Outcomes and pathological review of a cohort of children with melanoma. Br J Dermatol 2005; 152:1321-1323.
100. Rigel DS, Friedman RJ, Kopf AW, Polsky D. ABCDE: an evolving concept in the early detection of melanoma. Arch Dermatol 2005; 141:1032-1034.