Rationale and design of the healthy-cath trial: A randomised controlled trial of Heparin versus ethanol lock therapy for the prevention of catheter associated infection in haemodialysis patients

BMC Nephrology

Volumn 10, Issue 1, 2009, Pages

  Broom, Jennifer K ^a   O'Shea, Stacey ^b   Govindarajulu, Sridevi ^b   Playford, E Geoffrey ^b   Hawley, Carmel M ^b   Isbel, Nicole M ^b   Campbell, Scott B ^b   Mudge, David W ^b   Carpenter, Sally ^b   Johnson, Barbara C ^b   Underwood, Neil P ^b   Johnson, David W ^b  

^a NAMBOUR GENERAL HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; HEPARIN; SODIUM CHLORIDE; ANTICOAGULANT AGENT;

ARTICLE; BACTEREMIA; CATHETER INFECTION; CATHETER REMOVAL; CLINICAL TRIAL; CONTRACEPTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CULTURAL ANTHROPOLOGY; DIALYSIS CATHETER; DISEASE FREE SURVIVAL; HEALTH CARE COST; HEMODIALYSIS PATIENT; HUMAN; INCIDENCE; INFORMED CONSENT; INTRAVENOUS CATHETER; MAJOR CLINICAL STUDY; OPEN STUDY; OUTCOME ASSESSMENT; PREVALENCE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RELIGION; CHRONIC KIDNEY FAILURE; INDWELLING CATHETER; RENAL REPLACEMENT THERAPY; TREATMENT OUTCOME;

ANTICOAGULANTS; CATHETER-RELATED INFECTIONS; CATHETERS, INDWELLING; ETHANOL; HEPARIN; HUMANS; KIDNEY FAILURE, CHRONIC; RENAL DIALYSIS; TREATMENT OUTCOME;

EID: 69949170137     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-10-23     Document Type: Article

References (35)

1. Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis. KA Marr DJ Sexton PJ Conlon GR Corey SJ Schwab KB Kirkland, Ann Intern Med 1997 127 275 280 9265426
2. Staphylococcus aureus prophylaxis in hemodialysis patients using central venous catheter: effect of mupirocin ointment. R Sesso D Barbosa IL Leme H Sader ME Canziani S Manfredi, J Am Soc Nephrol 1998 9 1085 1092 9621293
3. A randomized, controlled trial of topical exit site mupirocin application in patients with tunnelled, cuffed haemodialysis catheters. DW Johnson R MacGinley TD Kay CM Hawley SB Campbell NM Isbel, Nephrol Dial Transplant 2002 17 1802 1807 10.1093/ndt/17.10.1802 12270988
4. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. DW Johnson C van Eps DW Mudge KJ Wiggins K Armstrong CM Hawley, J Am Soc Nephrol 2005 16 1456 1462 10.1681/ASN.2004110997 15788475 (Pubitemid 41716531)
5. Vascular access and all-cause mortality: a propensity score analysis. KR Polkinghorne SP McDonald RC Atkins PG Kerr, J Am Soc Nephrol 2004 15 477 486 10.1097/01.ASN.0000109668.05157.05 14747396 (Pubitemid 38140790)
6. Excerpts from the USRDS 2002 annual data report: Atlas of end-stage renal disease in the United States. USRDS, Am J Kidney Dis 2003 41 S1 S260 12751048
7. Vascular access use and outcomes: results from the DOPPS. RL Pisoni, Contrib Nephrol 2002 13 19 full-text 12101946
8. Epidemiology of vascular access in the Australian hemodialysis population. KR Polkinghorne SP McDonald RC Atkins PG Kerr, Kidney Int 2003 64 1893 1902 10.1046/j.1523-1755.2003.00277.x 14531825 (Pubitemid 37323721)
9. Vascular access practice patterns in the New Zealand hemodialysis population. KR Polkinghorne SP McDonald MR Marshall RC Atkins PG Kerr, Am J Kidney Dis 2004 43 696 704 10.1053/j.ajkd.2003.11.023 15042547 (Pubitemid 38401885)
10. Increased use of catheters as vascular access: is it justified by patients' clinical conditions? A Di Benedetto A Basci S Cesare D Marcelli P Ponce N Richards, J Vasc Access 2007 8 21 27 17393367
11. Haemodialysis vascular access problems in Canada: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS II). DC Mendelssohn J Ethier SJ Elder R Saran FK Port RL Pisoni, Nephrol Dial Transplant 2006 21 721 728 10.1093/ndt/gfi281 16311264 (Pubitemid 43372921)
12. Vascular access use in Europe and the United States: results from the DOPPS. RL Pisoni EW Young DM Dykstra RN Greenwood E Hecking B Gillespie, Kidney Int 2002 61 305 316 10.1046/j.1523-1755.2002.00117.x 11786113 (Pubitemid 34075158)
13. Vascular access use and outcomes: results from the DOPPS. RL Pisoni, Contrib Nephrol 2002 13 19 full-text 12101946
14. The hemodialysis catheter conundrum: hate living with them, but can't live without them. SJ Schwab G Beathard, Kidney Int 1999 56 1 17 10.1046/j.1523-1755.1999.00512.x 10411674 (Pubitemid 29300516)
15. The spectrum of infection-related morbidity in hospitalized haemodialysis patients. M Allon M Radeva J Bailey S Beddhu D Butterly DW Coyne, Nephrol Dial Transplant 2005 20 1180 1186 10.1093/ndt/gfh729 15769823 (Pubitemid 40862108)
16. Septicemia, access and cardiovascular disease in dialysis patients: the USRDS Wave 2 study. A Ishani AJ Collins CA Herzog RN Foley, Kidney Int 2005 68 311 318 10.1111/j.1523-1755.2005.00414.x 15954922 (Pubitemid 43181390)
17. Type of vascular access and mortality in U.S. hemodialysis patients. RK Dhingra EW Young TE Hulbert-Shearon SF Leavey FK Port, Kidney Int 2001 60 1443 1451 10.1046/j.1523-1755.2001.00947.x 11576358 (Pubitemid 32960038)
18. Vascular access and increased risk of death among hemodialysis patients. S Pastan JM Soucie WM McClellan, Kidney Int 2002 62 620 626 10.1046/j.1523-1755. 2002.00460.x 12110026 (Pubitemid 34779776)
19. Vascular access and all-cause mortality: a propensity score analysis. KR Polkinghorne SP McDonald RC Atkins PG Kerr, J Am Soc Nephrol 2004 15 477 486 10.1097/01.ASN.0000109668.05157.05 14747396 (Pubitemid 38140790)
20. A prospective study of the mechanisms of infection associated with hemodialysis catheters. JS Cheesbrough RG Finch RP Burden, J Infect Dis 1986 154 579 589 3745972
21. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention. NP O'Grady M Alexander EP Dellinger JL Gerberding SO Heard DG Maki, MMWR Recomm Rep 2002 51 1 29 12233868
22. Peritoneal dialysis-related infections recommendations: 2005 update. B Piraino GR Bailie J Bernardini E Boeschoten A Gupta C Holmes, Perit Dial Int 2005 25 107 131 15796137 (Pubitemid 40484720)
23. Effect of antimicrobial locks for tunneled hemodialysis catheters on bloodstream infection and bacterial resistance: a quality improvement report. SA Abbas IA Haloob SL Taylor EM Curry BB King WM Van der Merwe, Am J Kidney Dis 2009 53 492 502 10.1053/j.ajkd.2008.09.019 19150156
24. Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: a randomized controlled study. GK Dogra H Herson B Hutchison AB Irish CH Heath C Golledge, J Am Soc Nephrol 2002 13 2133 2139 10.1097/01.ASN.0000022890.29656.22 12138146 (Pubitemid 34790791)
25. Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials. D Yahav B Rozen-Zvi A Gafter-Gvili L Leibovici U Gafter M Paul, Clin Infect Dis 2008 47 83 93 10.1086/588667 18498236 (Pubitemid 351920592)
26. Sodium citrate versus heparin catheter locks for cuffed central venous catheters: a single-center randomized controlled trial. A Power N Duncan SK Singh W Brown E Dalby C Edwards, Am J Kidney Dis 2009 53 1034 1041 10.1053/j.ajkd.2009.01.259 19394731
27. Ethanol disinfection of plastic-adherent micro-organisms. ST Chambers B Peddie A Pithie, J Hosp Infect 2006 63 193 196 10.1016/j.jhin.2006.01.009 16600429
28. Mass spectrometry and scanning electron microscopy study of silicone tunneled dialysis catheter integrity after an exposure of 15 days to 60% ethanol solution. S Guenu AE Heng F Charbonne MJ Galmier F Charles P Deteix, Rapid Commun Mass Spectrom 2007 21 229 236 10.1002/rcm.2837 17171773 (Pubitemid 46095481)
29. The effects of prolonged ethanol exposure on the mechanical properties of polyurethane and silicone catheters used for intravascular access. CJ Crnich JA Halfmann WC Crone DG Maki, Infect Control Hosp Epidemiol 2005 26 708 714 10.1086/502607 16156328 (Pubitemid 41169741)
30. Infection control guidelines: Preventing infections associated with indwelling intravascular access devices. Bureau of Infectious Diseases Division of Nosocomial and Occupational Infections, Health Canada 1997 23 S8 S11
31. Tunneling short-term central venous catheters to prevent catheter-related infection: a meta-analysis of randomized, controlled trials. AG Randolph DJ Cook CA Gonzales C Brun-Buisson, Crit Care Med 1998 26 1452 1457 10.1097/00003246-199808000-00038 9710109
32. A semiquantitative culture method for identifying intravenous-catheter- related infection. DG Maki CE Weise HW Sarafin, N Engl J Med 1977 296 1305 1309 323710
33. Use of ethanol locks to prevent recurrent central line sepsis. SC Metcalf ST Chambers AD Pithie, J Infect 2004 49 20 22 10.1016/j.jinf.2003.08.010 15194244 (Pubitemid 38950243)
34. Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: results from a prospective trial. J Broom M Woods A Allworth J McCarthy J Faoagali S Macdonald, Scand J Infect Dis 2008 40 399 406 10.1080/00365540701756953 18418801 (Pubitemid 351566567)
35. Ethanol lock solution as an adjunct treatment for preventing recurrent catheter-related sepsis first case report in dialysis setting. C Ackoundou-N'guessan AE Heng S Guenu F Charbonne O Traore P Deteix, Nephrol Dial Transplant 2006 21 3339 3340 10.1093/ndt/gfl358 16854845 (Pubitemid 44567125)