Management strategies for recurrent ependymoma in the paediatric population

Child's Nervous System

Volumn 25, Issue 10, 2009, Pages 1283-1291

  Sangra, M ^a,c   Thorp, N ^b   May, P ^a   Pizer, B ^a   Mallucci, C ^a  

^a ALDER HEY CHILDREN'S NHS FOUNDATION TRUST   (United Kingdom)

^b CLATTERBRIDGE CENTRE FOR ONCOLOGY   (United Kingdom)

^c SOUTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Paediatric brain tumour; Radiotherapy; Re irradiation; Recurrent ependymoma; Survival

Indexed keywords

BUSULFAN; CARBOPLATIN; CISPLATIN; CYTARABINE; ETOPOSIDE; GANCICLOVIR; IMATINIB; TEMOZOLOMIDE; THIOTEPA;

CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CHILD; CLINICAL TRIAL; DRUG EFFICACY; DRUG MEGADOSE; EPENDYMOMA; HUMAN; LOW DRUG DOSE; PRIORITY JOURNAL; PROGNOSIS; RADIATION FIELD; RECURRENT CANCER; REOPERATION; REVIEW;

BRAIN NEOPLASMS; CHILD; EPENDYMOMA; HUMANS; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; SPINAL NEOPLASMS;

EID: 69949157219     PISSN: 02567040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00381-009-0914-7     Document Type: Review

References (58)

1. CBTRUS (2008). Statistical Report: Primary Brain Tumors in the United States, 2000-2004. Published by the Central Brain Tumor Registry of the United States.
2. M Vinchon P Leblond R Noudel P Dhellemmes 2005 Intracranial ependymomas in childhood: recurrence, reoperation, and outcome Childs Nerv Syst 21 221 226
3. IF Pollack PC Gerszten AJ Martinez KH Lo B Schultz AL Albright J Janosky M Deutsch 1995 Intracranial ependymomas of childhood: long-term outcome and prognostic factors Neurosurgery 37 655 667
4. PL Robertson PM Zeltzer JM Boyett LB Rorke JC Allen JR Geyer P Stanley H Li AL Albright P McGuire-Cullen JL Finlay KR Stevens JM Milstein RJ Packer J Wisoff 1998 Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children's Cancer Group J Neurosurg 88 695 703 (Pubitemid 28145213)
5. J Grill MC Le Deley D Gambarelli MA Raquin D Couanet A Pierre-Kahn JL Habrand F Doz D Frappaz JC Gentet C Edan P Chastagner C Kalifa 2001 Postoperative chemotherapy without irradiation for ependymoma in children under 5 years of age: a multicenter trial of the French Society of Pediatric Oncology J Clin Oncol 19 1288 1296
6. JW Goldwein TA Glauser RJ Packer JL Finlay LN Sutton WJ Curran JM Laehy LB Rorke L Schut GJ D'Angio 1990 Recurrent intracranial ependymomas in children. Survival, patterns of failure, and prognostic factors Cancer 66 557 563
7. M Massimino F Giangaspero ML Garre L Genitori G Perilongo P Collini D Riva L Valentini G Scarzello G Poggi F Spreafico P Peretta M Mascarin P Modena G Sozzi N Bedini V Biassoni A Urgesi MR Balestrini G Finocchiaro A Sandri L Gandola 2006 Salvage treatment for childhood ependymoma after surgery only: pitfalls of omitting "at once" adjuvant treatment Int J Radiation Oncology Biol Phys 65 1440 1445
8. MC van Veelan-Vincent A Pierre-Kahn C Kalifa C Sainte-Rose M Zerah J Thorne D Renier 2002 Ependymoma in childhood: prognostic factors, extent of surgery and adjuvant therapy J Neurosurg 97 827 835
9. JR Geyer R Sposto M Jennings JM Boyett RA Axtell D Breiger E Broxson B Donahue JL Finlay JW Goldwein LA Heier D Johnson C Mazewski DC Miller R Packer D Puccetti J Radcliffe ML Tau T Shiminski-Maher 2005 Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the children's cancer group J Clin Oncol 23 7621 7631
10. RG Grundy SA Wilne CL Weston K Robinson LS Lashford J Ironside T Cox W Kling Chong RHA Campbell CC Bailey R Gattamaneni S Picton N Thorpe C Mallucci MW English JAG Punt DA Walker DW Ellison D Machin 2007 Primary postoperative chemotherapy without radiotherapy for intracranial ependymoma in children: the UKCCSG/SIOP prospective study Lancet 8 696 705
11. P Rousseau JL Habrand D Sarrazin C Kalifa MJ Terrier-Lacombe C Rekacewicz A Rey 1994 Treatment of intracranial ependymomas of children: review of a 15-year experience Int J Radiat Oncol Biol Phys 28 381 386
12. AE Evans JR Anderson IB Lefkowitz-Boudreaux J Finlay 1996 Adjuvant chemotherapy of childhood posterior fossa ependymoma: craniospinal irradiation with or without adjuvant CCNU, vincristine, and prednisolone: a Childrens Cancer Group study Med Pediatr Oncol 27 8 14
13. W Mason S Goldman AJ Yates J Boyett H Li JL Finlay 1998 Survival following intensive chemotherapy with bone marrow reconstitution for children with recurrent intracranial ependymoma J Neurooncol 37 135 143
14. PK Duffner JP Krischer RA Sanford ME Horowitz PC Burger ME Cohen HS Friedman LE Kun 1998 Prognostic factors in infants and very young children with intracranial ependymomas Pediatr Neurosurg 28 215 222
15. AK Liu NK Foreman LE Gaspar E Trinidad MH Handlar 2009 Maximally safe resection followed by hypofractionated re-irradiation for locally recurrent ependymoma in children Pediatr Blood Cancer 52 804 807
16. CS [tmp] McGuire KL Sainani PG Fisher 2009 Incidence patterns for ependymoma, and end-results study J Neurosurg 110 725 729
17. MK Lyons PJ Kelly 1991 Posterior fossa ependymomas: report of 30 cases and review of the literature Neurosurgery 28 659 665
18. DR Copeland C deMoor BD Moore III JL Ater 1999 Neurocognitive development of children after a cerebellar tumor in infancy: a longitudinal study J Clin Oncol 17 3476 3486
19. BJ Spiegler E Bouffet ML Greenberg JT Rutka DJ Mabbott 2004 Change in neurocognitive functioning after treatment with cranial radiation in childhood J Clin Oncol 22 706 713
20. TE Merchant JJ Jenkins PC Burger RA Sanford SH Sherwood D Jones-Wallace RL Heideman SJ Thompson KJ Helton LE Kun 2002 Influence of tumor grade on time to progression after irradiation for localized ependymoma in children Int J Radiat Oncol Biol Phys 53 52 57
21. Godfraind C (2009) Classification and controversies in pathology of ependymomas. Childs Nerv Syst. 2009 Feb 11. [online publication]
22. S Ward B Harding P Wilkins W Harkness R Hayward JL Darling DG Thomas T Warr 2001 Gain of 1q and loss of 22 are the most common changes detected by comparative genomic hybridization in paediatric ependymoma Genes Chromosomes Cancer 32 59 66
23. U Tabori M Jing M Carter M Zielenska J Rutka E Bouffet U Bartels D Malkin C Hawkins 2006 Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymoma J Clin Oncol 24 1522 1528
24. S Dyer E Prebble V Davison P Davies P Ramani D Ellison R Grundy 2002 Genomic imbalances in pediatric ependymomas define clinically relevant groups Am J Path 161 2133 2141
25. E Bouffet G Perilongo A Canete M Massimino 1998 Intracranial ependymomas in children: a critical review of prognostic factors and a plea for cooperation Med Pediatr Oncol 30 329 331
26. TE Merchant T Haida MH Wang JL Finlay SA Leibel 1997 Anaplastic ependymoma: treatment of pediatric patients with or without craniospinal radiation therapy J Neurosurg 86 943 949
27. PK Duffner ME Horowitz JP Krischer HS Friedman PC Burger ME Cohen RA Sanford RK Mulhern HE James CR Freeman FG Seidel E Larry 1993 Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors NEJM 328 1725 1731
28. E Bouffet U Tabori U Bartels 2007 Paediatric ependymomas: should we avoid radiotherapy? Lancet Oncol 8 665 666
29. T Merchant C Li X Xiong LE Kun FA Boop RA Sanford 2009 Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study Lancet Oncol 10 258 266
30. CD Good AM Wade RD Hayward KP Phipps AJ Michalski WF Harkness WK Chong 2001 Surveillance neuroimaging in childhood intracranial ependymoma: how effective, how often, and for how long? J Neurosurg 94 27 32
31. X Qian LC Goumnerova U De Girolami ES Cibas 2008 Cerebrospinal fluid cytology in patients with ependymoma: a bi-institutional retrospective study Cancer 114 307 314
32. T Merchant R Mulhern M Krasin, et al. 2004 Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma J Clin Oncol 22 3156 3162
33. S Stafford B Pollock R Foote 2000 Stereotactic radiosurgery for recurrent ependymoma Cancer 88 870 875
34. H Kano A Nirnjan D Konziolka, et al. 2009 Outcome predictors for intracranial ependymoma radiosurgery Neurosurgery 64 279 287
35. M Kinoshita S Izumoto N Kagawa, et al. 2004 Long-term control of recurrent anaplastic ependymoma with extracranial metastasis: importance of multiple surgery and stereotactic radiosurgery procedures-case report Neurol Med Chir (Tokyo) 44 669 673
36. D Kirsch N Tarbell 2004 New technologies in radiation therapy for pediatric brain tumors: the rationale for proton radiation therapy Pediatr Blood Cancer 42 461 464
37. SM [tmp] MacDonald S Safai A Trofimov, et al. 2008 Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons Int J Radiat Oncol Biol Phys 71 979 986
38. D Olsen O Bruland G Frykholm 2007 Proton therapy-a systematic review of clinical effectiveness Radiother Oncol 83 123 132
39. T Merchant C Hua H Shukla 2008 Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function Pediatr Blood Cancer 51 110 117
40. C Lee S Bilton R Famigletti, et al. 2005 Treatment planning with protons for pediatric retinoblastoma, medulloblastoma and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Rad Oncol Biol Phys 63 362 372
41. M Goitein M Jermann 2003 The relative costs of proton and X-ray radiation therapy Clin Onc 15 S37 S50
42. Bouffet E, Capra M, Bartels U (2009) Salvage chemotherapy for metastatic and recurrent ependymoma of childhood. Childs Nerv Syst. 2009 Apr 10. [Epub ahead of print]
43. CL Sexauer A Khan PC Burger JP Krischer J van Eys T Vats AH Ragab 1985 Cisplatin in recurrent pediatric brain tumors. A POG Phase II study. A Pediatric Oncology Group study Cancer 56 1497 1501
44. A Sandri M Massimino L Mastrodicasa N Sardi D Bertin ME Basso L Todisco A Paglino G Perilongo L Genitori L Valentini U Ricardi L Gandola F Giangaspero E Madon 2005 Treatment with oral etoposide for childhood recurrent ependymomas J Pediatr Hematol Oncol 27 486 490
45. MC Chamberlain 2001 Recurrent intracranial ependymoma in children: salvage therapy with oral etoposide Pediatr Neurol 24 117 121
46. RL Heideman RJ Packer GH Reaman JC Allen B Lange ME Horowitz SM Steinberg A Gillespie EH Kovnar FM Balis, et al. 1993 A phase II evaluation of thiotepa in pediatric central nervous system malignancies Cancer 72 271 275
47. HS Nicholson CS Kretschmar M Krailo M Bernstein R Kadota D Fort H Friedman MB Harris N Tedeschi-Blok C Mazewski J Sato GH Reaman 2007 Phase 2 study of temozolamide in children and adolescents with recurrent central nervous system tumors Cancer 110 1542 1550
48. R Yoffe Y Khakoo IJ Dunkel M Souweidane E Lis C Sklar 2005 Recurrent ependymoma treated with high-dose tamoxifen in a peripubertal female: impact on tumor and the pituitary-ovarian axis Pediatr Blood Cancer 49 5 758 760
49. S Rehman C Brock E Newlands 2006 A case report of a recurrent intracranial ependymoma treated with temozolamide in remission 10 years after completing chemotherapy Am J Clin Oncol 29 106 107
50. J Grill C Kalifa F Doz C Schoepfer C Sainte-Rose D Couanet MJ Terrier-Lacombe HO Valteau-Couanet 1996 A high-dose busulfan-thiotepa combination followed by autologous bone marrow transplantation in childhood recurrent ependymoma Pediatr Neurosurg 25 7 12
51. AM Buccoliero F Castiglione D Rossi Degl'Innocenti M Paglierani V Maio CF Gheri F Garbini D Moncini A Taddei I Sardi M Sanzo F Giordano F Mussa L Genitori GL Taddei 2008 O6-Methylguanine-DNA-methyltransferase in recurring anaplastic ependymomas: PCR and immunohistochemistry Chemotherapy 20 263 268
52. A Korshunov R Sycheva V Timirgaz A Golanov 1999 Prognostic value of immunoexpression of the chemoresistance-related proteins in ependymomas: an analysis of 76 cases J Neurooncol 45 219 227 (Pubitemid 30315739)
53. TE Merchant FA Boop LE Kun RA Sanford 2008 A retrospective study of surgery and re-irradiation for recurrent ependymoma Int J Radiation Oncology Biol Phys 71 87 97
54. U Tabori V Wong M Jing M Shago N Alon J Rutka E Bouffet U Bartels D Malkin C Hawkins 2008 Telomere maintenance and dysfunction predict recurrence in pediatric ependymoma Br J Cancer 99 1129 1135
55. N Fakhrai P Neophytou K Dieckmann A Nemeth D Prayer J Hainfellner C Marosi 2004 Recurrent spinal ependymoma showing partial remission under Imatimib Acta Neurochir (Wien) 146 1255 1258
56. CM Kramm D Korholz NG Rainov T Niehues U Fischer S Steffens S Frank U Banning G Horneff H Schroten S Burdach 2002 Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient Neuropediatrics 33 6 9
57. A Lassaletta P Perez-Olleros C Scaglione S Sirvent I De Prada A Perez-Martinez A Ruiz-Hernandez L Madero 2007 Successful treatment of intracranial ependymoma with leptomeningeal spread with systemic chemotherapy and intrathecal liposomal cytarabine in a two-year-old child J Neurooncol. 83 303 306
58. S Gururangan WP Petros TY Poussaint ML Hancock PC Phillips HS Friedman L Bomgaars SM Blaney LE Kun JM Boyett 2006 Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004) Clin Cancer Res 12 1540 1546