Salvage treatment for childhood ependymoma after surgery only: Pitfalls of omitting "at once" adjuvant treatment

International Journal of Radiation Oncology Biology Physics

Volumn 65, Issue 5, 2006, Pages 1440-1445

  Massimino, Maura ^a   Giangaspero, Felice ^b,c   Garrè, Maria Luisa ^d   Genitori, Lorenzo ^e   Perilongo, Giorgio ^f   Collini, Paola ^a   Riva, Daria ^g   Valentini, Laura ^g   Scarzello, Giovanni ^f   Poggi, Geraldina ^h   Spreafico, Filippo ^a   Peretta, Paola ⁱ   Mascarin, Maurizio ^k   Modena, Piergiorgio ^a   Sozzi, Gabriella ^a   Bedini, Nice ^a   Biassoni, Veronica ^a   Urgesi, Alessandro ⁱ   Balestrini, Maria Rosa ^g   Finocchiaro, Gaetano ^j   Sandri, Alessandro ^j   Gandola, Lorenza ^a   more..

^a NATIONAL CANCER INSTITUTE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c IRCCS NEUROMED   (Italy)

^d G GASLINI INSTITUTE   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

^f UNIVERSITY OF PADOVA   (Italy)

^g DEPARTMENT OF NEUROSURGERY   (Italy)

^h SCIENTIFIC INSTITUTE   (Italy)

ⁱ Neurosurgery Unit   (Italy)

^j REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

^k CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

more..

Author keywords

Adjuvant treatment; Ependymoma; Second look surgery

Indexed keywords

BRAIN; CHEMOTHERAPY; DIAGNOSIS; NEUROSURGERY; RADIOTHERAPY; TUMORS;

ADJUVANT TREATMENT; EPENDYMOMA (EPD); POSTERIOR FOSSA (PF); SECOND-LOOK SURGERY; TUMOR EXCISIONS;

PEDIATRICS;

CYCLOPHOSPHAMIDE; ETOPOSIDE; VINCRISTINE;

ADOLESCENT; ARTICLE; BRAIN TUMOR; CANCER ADJUVANT THERAPY; CANCER GROWTH; CANCER RELAPSE; CANCER SURGERY; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CRANIAL NERVE PARALYSIS; EPENDYMOMA; FEMALE; HUMAN; HYDROCEPHALUS; ITALY; MALE; MEDICAL SOCIETY; MENINGITIS; MINIMAL RESIDUAL DISEASE; PATIENT REFERRAL; POSTERIOR CRANIAL FOSSA TUMOR; PRIORITY JOURNAL; PROGNOSIS; RECURRENT INFECTION; SALVAGE THERAPY; TREATMENT OUTCOME; ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; METHODOLOGY; PRESCHOOL CHILD;

ADOLESCENT; BRAIN NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CHILD; CHILD, PRESCHOOL; EPENDYMOMA; FEMALE; HUMANS; NEOPLASM, RESIDUAL; RADIOTHERAPY, ADJUVANT; SALVAGE THERAPY; TREATMENT OUTCOME;

EID: 33748531837     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.03.052     Document Type: Article

References (44)

1. CBTRUS: Statistical report: Primary brain tumors in the United States, 1995-1999 (2002), Central Brain Tumor Registry of the United States, Hinsdale, IL
2. Nazar G.B., Hoffman H.J., Becker L.E., et al. Infratentorial ependymomas in childhood. Prognostic factors and treatment. J Neurosurg 72 (1990) 408-417
3. Robertson P.L., Zeltzer P.M., Boyett J.M., et al. Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children. A report of the Children's Cancer Group. J Neurosurg 88 (1998) 695-703
4. Schild S.E., Nisi K., Scheithauer B.W., et al. The results of radiotherapy for ependymoma. The Mayo Clinic Experience. Int J Radiat Oncol Biol Phys 5 (1998) 953-958
5. McLaughin M.P., Marcus R.B., Buatti J.M., et al. Ependymoma. Results, prognostic factors and treatment recommendations. Int J Radiat Oncol Biol Phys 40 (1998) 845-850
6. Vanuystel L.J., Bessell E.M., Ashley S.E., et al. Intracranial ependymoma. long-term results of a policy of surgery and radiotherapy. Int J Radiat Oncol Biol Phys 23 (1992) 313-319
7. Timmermann B., Kortmann R.F., Kühl J., et al. Combined postoperative irradiation and chemotherapy for anaplastic ependymoma in childhood. Results of the German prospective trials HIT 88/89 and HIT 91. Int J Radiat Oncol Biol Phys 2 (2000) 287-295
8. Bouffet E., Perilongo G., Canete A., and Massimino M. Intracranial ependymomas in children. A critical review of prognostic factors and a plea for cooperation. Med Pediatr Oncol 30 (1998) 319-331
9. Perilongo G., Massimino M., Sotti G., et al. Analyses of prognostic factors in a retrospective review of 92 children with ependymoma. Italian pediatric neuro-oncology group. Med Pediatr Oncol 29 (1997) 79-85
10. Grill J., Le Deley M.C., Gambarelli, et al. Postoperative chemotherapy without irradiation for ependymoma in children under 5 years of age. A multicenter trial of the French Society of Pediatric Oncology. J Clin Oncol 19 (2001) 1288-1296
11. Healey E.A., Barnes P.D., Kupsky W.J., et al. The prognostic significance of post-operative residual tumor in ependymoma. Neurosurgery 28 (1991) 666-672
12. Spagnoli D., Tomei G., Ceccarelli G., et al. Combined treatment of fourth ventricle ependymomas. report of 26 cases. Surg Neurol 54 (2000) 19-26
13. Sutton L.N., Goldwein J., Perilongo G., et al. Prognostic factors in childhood ependymomas. Pediatr Neurosurg 16 (1990) 57-65
14. Kricheff I.I., Becker M., Schneck S.A., et al. Intracranial ependymomas. factors influencing prognosis. J Neurosurg 21 (1964) 7-14
15. Ikezaki K., Matsushima T., Inoue T., et al. Correlation of microanatomical localization with postoperative survival in posterior fossa ependymomas. Neurosurgery 32 (1993) 38-44
16. Horn B., Heideman R., Geyer R., et al. A multi-institutional retrospective study of intracranial ependymoma in children. identification of risk factors. J Pediatr Hematol Oncol 21 (1999) 203-211
17. Tomita T., McLone D.G., Das L., et al. Benign ependymomas of the posterior fossa in childhood. Pediatr Neurosci 14 (1998) 277-285
18. Foreman N.K., Love S., Gill S.S., and Coakham H.B. Second-look surgery for incompletely resected fourth ventricle ependymomas. Technical case report. Neurosurgery 40 (1997) 856-860
19. Massimino M., Gandola L., Giangaspero F., et al. Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma. Final results of the first prospective AIEOP (Associazione Italiana di Ematologia ed Oncologia Pediatrica) study. Int J Radiat Oncol Biol Phys 58 (2004) 1336-1345
20. Merchant T.E. Current management of childhood ependymoma. Oncology 16 (2002) 629-648
21. Mørk S.V., and LøKen A.C. Ependymoma. A follow-up study of 101 cases. Cancer 40 (1977) 907-915
22. Pollack I.F., Gerszten P.C., Martinez A.J., et al. Intracranial ependymomas of childhood. Long-term outcome and prognostic factors. Neurosurgery 37 (1995) 665-667
23. Rousseau P., Habrand J.L., Sarrazin D., et al. Treatment of intracranial ependymomas of children. Review of a 15-year experience. Int J Radiat Oncol Biol Phys 28 (1994) 381-386
24. Geyer J.R., Sposto R., Jennings M., et al. Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors. a report from the Children's Cancer Group. J Clin Oncol 23 (2005) 7621-7631
25. Afra D., Muller W., Slowik F., et al. Supratentorial lobar ependymomas. reports of the grading and survival periods in 80 cases, including 46 recurrences. Acta Neurochir 69 (1983) 243-251
26. Matson D.D. Neurosurgery of infancy and childhood. 2nd ed. (1969), Charles C Thomas, Springfield, IL p. 502-510
27. Olivecrona H. The surgical treatment of intracranial tumors. In: Olivecrona H., and Tönnis W. (Eds). Handbuch der neurochirurgie (1967), Springer-Verlag, Berlin 1-47
28. Awaad Y.M., Allen J.C., Miller D.C., et al. Deferring adjuvant therapy for totally resected intracranial ependymoma. Pediatr Neurol 14 (1996) 216-219
29. Guyotat J., Signorelli F., Desme S., et al. Intracranial ependymomas in adult patients. Analyses of prognostic factors. J Neurooncol 60 (2002) 255-268
30. Hukin J., Epstein F., Lefton D., et al. Treatment of intracranial ependymoma by surgery alone. Pediatr Neurosurg 29 (1998) 40-45
31. Reni M., Brandes A.A., Vavassori V., et al. A multicenter study of the prognosis and treatment of adult brain ependymal tumors. Cancer 100 (2004) 1221-1229
32. Palma L., Celli O.P., Margottino A., et al. The importance of surgery in supratentorial ependymomas. Long-term survival in a series of 23 cases. Childs Nerv Syst 16 (2000) 170-175
33. Kaplan E.L., and Meier P. Non parametric estimation from incomplete observation. J Am Stat Assoc 53 (1958) 457-481
34. Cox R. Regression models and life tables. J Royal Stat Soc 34 (1972) 187-202
35. Duffner P.K., Horowitz M.E., Krischer J.P., et al. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 328 (1993) 1725-1731
36. Pierre-Kahn A., Hirsh J.F., Roux F.X., et al. Intracranial ependymoma in childhood. Survival and functional results of 47 cases. Childs Brain 10 (1983) 145-156
37. Merchant T.E., Mulhern R.K., Krasin M.J., et al. Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol 22 (2004) 3156-3162
38. Robertson P.L., Zeltzer P.M., Boyett J.M., et al. Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children. A report of the Children's Cancer Group. J Neurosurg 88 (1998) 695-703
39. Riva D., and Giorgi C. The cerebellum contributes to higher functions during development. Evidence from a series of children surgically treated for posterior fossa tumours. Brain 123 (2000) 1051-1061
40. Poggi G., Liscio M., Adduci A., et al. Psychological and adjustment problems due to acquired brain lesions in childhood. A comparison between post-traumatic patients and brain tumour survivors. Brain Injury 19 (2005) 777-785
41. Rogers L., Pueschel J., Spetzler R., et al. Is gross-total resection sufficient treatment for posterior fossa ependymomas?. J Neurosurg 102 (2005) 629-636
42. Taylor M.D., Poppleton H., Fueller C., et al. Radial glial cells are candidate stem cells of ependymoma. Cancer Cell 8 (2005) 323-335
43. Modena P., Weltman J., Lualdi E., et al. Molecular profiling of pediatric intracranial ependymoma. 37th Annual Conference of The International Society of Paediatric Oncology SIOP 2005. [Abstract]. Pediatr Blood Cancer 45 (2005) 392
44. Van Veelen-Vincent M.L., Pierre-Kahn A., Kalifa C., et al. Ependymoma in childhood. Prognostic factors, extent of surgery and adjuvant therapy. J Neurosurg 97 (2002) 827-835