Testing hardy-Weinberg equilibrium using mother-child case-control samples

Genetic Epidemiology

Volumn 33, Issue 6, 2009, Pages 539-548

  Chen, Jinbo ^a   Zheng, Haitao ^a   Wilson, Melissa L ^b   Kraft, Peter ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Hardy Weinberg equilibrium; Maternal genotype; Obstetric complications; Offspring genotype; Sampling probabilities; Weighted counts; X2 test

Indexed keywords

ANALYTICAL ERROR; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; FETUS; GENETIC MODEL; GENOTYPE; HUMAN; INTERMETHOD COMPARISON; MATERNAL HYPERTENSION; PHENOTYPE; POPULATION GENETICS; PREGNANCY COMPLICATION; PREMATURITY; PROBABILITY; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM;

CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; HYPERTENSION, PREGNANCY-INDUCED; PHENOTYPE; PILOT PROJECTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY;

EID: 69949136557     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20406     Document Type: Article

References (16)

1. Bourgain C, Schneider D, Ober C, Mcpeek MS. 2004. Testing for Hardy-Weinberg Equilibrium in samples with related individuals. Genetics 168:2349-2361.
2. Chen J, Chatterjee N. 2007. Exploiting Hardy-Weinberg equilibrium for efficient screening of single SNP associations from case-control studies. Hum Hered 63:196-204.
3. Cox DG, Kraft P. 2006. Quantification of the power of Hardy Weinberg equilibrium testing to detect genotype error. Hum Hered 61:10-14.
4. Dekker GA, Sibai BM. 1998. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 179:1359-1375.
5. Hernandez JL,Weir BS. 1989. A disequilibrium coefficient approach to Hardy-Weinberg testing. Biometrics 45:53-70.
6. Horvitz DG, Thompson DJ. 1952. A generalization of sampling without replacement from a finite universe. J Am Stat Assoc 47:663-685.
7. Leal SM. 2003. Detection of genotyping error of pseudo-SNPs via deviations from Hardy-Weinberg equilibrium. Genet Epidemiol 29:204-214.
8. LEE WC. 2003. Searching for disease-susceptibility loci by testing for Hardy-Weinberg disequilibrium in a gene bank of affected individuals. Am J Epidemiol 158:379-400.
9. Liston WA, Kilpatrick DC. 1991. Is genetic susceptibility to pre-eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus? Br J Obstet Gynecol 98: 1079-1086.
10. Nielsen D, Ehm MG, Weir B. 1999. Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. Am J Hum Genet 63:1531-1540.
11. Schaid D, Batzler AJ, Jenkins GD, Hildebrandt MA. 2006. Exact tests of Hardy-Weinberg equilibrium and homogeneity of disequilibrium across strata. Am J Hum Genet 79:1071-1080.
12. Sinsheimer JS, Palmer CGS, Woodward JA. 2003. Detecting genotype combinations that increase risk for disease: the maternal-fetal genotype incompatibility test. Genet Epidemiol 24:1-13.
13. Weinberg C, Morris RW. 2003. Invited commentary: testing for Hardy-Weinberg disequilibrium using a genome single nucleotide polymorphism scan based on cases only. Am J Epidemiol 158: 401-403.
14. Weir BS, Genetic data analysis II. 1996. Methods for Discrete Population Genetic Data. Sunderland, MA: Sinauer Associates.
15. Wilson ML, Goodwin TM, Pan VL, Ingles SA. 2003. Molecular epidemiology of preeclampsia. Obstet Gynecol Surv 58:39-66.
16. Wittke-Thompson JK, Pluzhnikov A, Cox NJ. 2005. Rational inferences about departures from Hardy-Weinberg equilibrium. Am J Hum Genet 76:967-986.