Ohr, an in vivo-induced gene in Actinobacillus pleuropneumoniae, is located on a genomic island and requires glutathione-S-transferase for activity

FEMS Immunology and Medical Microbiology

Volumn 57, Issue 1, 2009, Pages 59-68

  Wolfram, Thaddeus J ^a,b,c   LeVeque, Rhiannon M ^a,b   Kastenmayer, Robin J ^a,d   Mulks, Martha H ^a,b  

^a Michigan State University ^*  (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Actinobacillus pleuropneumoniae; Genomic island; Glutathione S transferase; Ohr

Indexed keywords

GLUTATHIONE TRANSFERASE;

ACTINOBACILLUS PLEUROPNEUMONIAE; ARTICLE; BACTERIAL GENE; ENZYME ACTIVITY; GENE ACTIVITY; GENE IDENTIFICATION; GENE LOCATION; GENE SEQUENCE; GENOMIC ISLAND; NONHUMAN; NUCLEOTIDE SEQUENCE; OHR GENE; OPEN READING FRAME; PRIORITY JOURNAL; SEROTYPE;

ACTINOBACILLUS PLEUROPNEUMONIAE; ANIMALS; BACTERIAL PROTEINS; DNA, BACTERIAL; GENE ORDER; GENOMIC ISLANDS; GLUTATHIONE TRANSFERASE; MOLECULAR SEQUENCE DATA; PEROXIDASES; SEQUENCE ANALYSIS, DNA; SWINE;

EID: 69949122897     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2009.00579.x     Document Type: Article

References (27)

1. Beynon LM, Griffith DW, Richards JC Perry MB (1992) Characterization of the lipopolysaccharide O antigens of Actinobacillus pleuropneumoniae serotypes 9 and 11: antigenic relationships among serotypes 9, 11, and 1. J Bacteriol 174 : 5324 5331.
2. Bosse JT, Janson H, Sheehan BJ, Beddek AJ, Rycroft AN, Kroll JS Langford PR (2002) Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection. Microbes Infect 4 : 225 235.
3. Chevallier B, Dugourd D, Tarasiuk K, Harel J, Gottschalk M, Kobisch M Frey J (1998) Chromosome sizes and phylogenetic relationships between serotypes of Actinobacillus pleuropneumoniae. FEMS Microbiol Lett 160 : 209 216.
4. Chuchue T, Tanboon W, Prapagdee B, Dubbs JM, Vattanaviboon P Mongkolsuk S (2006) OhrR and ohr are the primary sensor/regulator and protective genes against organic hydroperoxide stress in Agrobacterium tumefaciens. J Bacteriol 188 : 842 851.
5. Cussiol JR, Alves SV, de Oliveira MA Netto LE (2003) Organic hydroperoxide resistance gene encodes a thiol-dependent peroxidase. J Biol Chem 278 : 11570 11578.
6. Fenwick B Henry S (1994) Porcine pleuropneumonia. J Am Vet Med Assoc 204 : 1334 1340.
7. Foote SJ, Bosse JT, Bouevitch AB, Langford PR, Young NM Nash JH (2008) The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b). J Bacteriol 190 : 1495 1496.
8. Fuller TE, Thacker BJ Mulks MH (1996) A riboflavin auxotroph of Actinobacillus pleuropneumoniae is attenuated in swine. Infect Immun 64 : 4659 4664.
9. Fuller TE, Shea RJ, Thacker BJ Mulks MH (1999) Identification of in vivo induced genes in Actinobacillus pleuropneumoniae. Microb Pathogenesis 27 : 311 327.
10. Fuller TE, Thacker BJ, Duran CO Mulks MH (2000) A genetically-defined riboflavin auxotroph of Actinobacillus pleuropneumoniae as a live attenuated vaccine. Vaccine 18 : 2867 2877.
11. Fussing V, Barfod K, Nielsen R, Moller K, Nielsen JP, Wegener HC Bisgaard M (1998) Evaluation and application of ribotyping for epidemiological studies of Actinobacillus pleuropneumoniae in Denmark. Vet Microbiol 62 : 145 162.
12. Gram T, Ahrens P, Andreasen M Nielsen JP (2000) An Actinobacillus pleuropneumoniae PCR typing system based on the apx and omlA genes - evaluation of isolates from lungs and tonsils of pigs. Vet Microbiol 75 : 43 57.
13. Habig W, Pabst MJ Jakoby WB (1974) Glutathione-S-transferase: the first enzymatic step in mercapturic acid formation. J Biol Chem 249 : 7130 7139.
14. Hacker J Kaper J (2000) Pathogenicity islands and the evolution of microbes. Annu Rev Microbiol 54 : 641 679.
15. Hong SH, Kim JS, Lee SY, In YH, Choi SS, Rih JK, Kim CH, Jeong H, Hur CG Kim JJ (2004) The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens. Nat Biotechnol 22 : 1275 1281.
16. Kokotovic B Angen O (2007) Genetic diversity of Actinobacillus pleuropneumoniae assessed by amplified fragment length polymorphism (AFLP) analysis. J Clin Microbiol 45 : 3921 3929.
17. Mongkolsuk S, Panmanee W, Atichartpongkul S, Vattanaviboon P, Whangsuk W, Fuangthong M, Eiamphungporn W, Sukchawalit R Utamapongchai S (2002) The repressor for an organic peroxide-inducible operon is uniquely regulated at multiple levels. Mol Microbiol 44 : 793 802.
18. Redfield RJ, Findlay WA, Bosse J, Kroll JS, Cameron AD Nash JH (2006) Evolution of competence and DNA uptake specificity in the Pasteurellaceae. BMC Evol Biol 6 : 82.
19. Rycroft AN Garside LH (2000) Actinobacillus species and their role in animal disease. Vet J 159 : 18 36.
20. Shea RJ Mulks MH (2002) Ohr, encoding an organic hydroperoxide reductase, is an in vivo-induced gene in Actinobacillus pleuropneumoniae. Infect Immun 70 : 794 802.
21. Silhavy TJ (1984) DNA extraction from bacterial cells. Experiments with Gene Fusions (Silhavy TJ, ed). 137 139. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
22. Sukchawalit R, Loprasert S, Atichartpongkul S Mongkolsuk S (2001) Complex regulation of the organic hydroperoxide resistance gene (ohr) from Xanthomonas involves OhrR, a novel organic peroxide-inducible negative regulator, and posttranscriptional modifications. J Bacteriol 183 : 4405 4412.
23. Taylor DJ (1999) Actinobacillus pleuropneumoniae. Diseases of Swine (Straw BE, D'Allaire S, Mengeling WL Taylor DJ, eds). 343 354. Iowa State University Press, Ames, IA.
24. Wagner TK Mulks MH (2006) A subset of Actinobacillus pleuropneumoniae in vivo induced promoters respond to branched-chain amino acid limitation. FEMS Immunol Med Mic 48 : 192 204.
25. West SE, Romero MJ, Regassa LB, Zielinski NA Welch RA (1995) Construction of Actinobacillus pleuropneumoniae-Escherichia coli shuttle vectors: expression of antibiotic-resistance genes. Gene 160 : 81 86.
26. Xu Z, Zhou Y Li L (2008) Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China. PLoS One 3 : e1450.
27. Zablotowicz RM, Hoagland RE, Locke MA Hickey WJ (1995) Glutathione-S-transferase activity and metabolism of glutathione conjugates by rhizosphere bacteria. Appl Environ Microb 61 : 1054 1060.