A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude mice

Apoptosis

Volumn 14, Issue 10, 2009, Pages 1190-1203

  Brabant, Magali ^a,b   Baux, Ludwig ^a   Casimir, Richard ^a,b,c   Briand, Jean Paul ^c   Chaloin, Olivier ^c   Porceddu, Mathieu ^a,b   Buron, Nelly ^a,b   Chauvier, David ^a,b   Lassalle, Myriam ^a   Lecoeur, Hervé ^a   Langonné, Alain ^a   Dupont, Sylvie ^a   Déas, Olivier ^a   Brenner, Catherine ^d   Rebouillat, Dominique ^a   Muller, Sylviane ^c   Borgne Sanchez, Annie ^a,b   Jacotot, Etienne ^a,e  

^a Theraptosis SA   (France)

^b Theraptosis SA   (France)

^c INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Cell death; Dengue virus; Mitochondria; Peptide; Tumor xenograft

Indexed keywords

CHIMERIC PROTEIN; HIV 1 TAT TRANSDUCTION DOMAIN PROTEIN; M PROTEIN; TAT[49-57] GLYCYLGLYCYLARGINYLISOLEUCYLALANYLISOLEUCYLTRYPTOPHYLISOLEUCYLLYSYLARGINYLHISTID INAMIDE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL PERMEABILIZATION; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN DOMAIN; VIRUS GENOME; XENOGRAFT;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; FLAVIVIRUS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL SWELLING; MOLECULAR SEQUENCE DATA; PEPTIDES; PERMEABILITY; PROTEIN STRUCTURE, TERTIARY; SURVIVAL ANALYSIS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIRAL PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; DENGUE VIRUS; DENGUE VIRUS GROUP; FLAVIVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MUS; MUS MUSCULUS;

EID: 69949118791     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0394-y     Document Type: Article

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