Expression and function of ETA and ETB receptors in SSc

Rheumatology

Volumn 47, Issue SUPPL. 5, 2009, Pages

  Frommer, K W ^a   Muller Ladner U ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Diseases; Endothelin; EndothelinA receptors; EndothelinB receptors; Expression; Function; Scleroderma; Signalling; Systemic sclerosis

Indexed keywords

AMBRISENTAN; ANGIOTENSIN II; BASIC FIBROBLAST GROWTH FACTOR; BOSENTAN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYCLIC AMP; ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN 3; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; EPIDERMAL GROWTH FACTOR; FOCAL ADHESION KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C; SITAXSENTAN; TRANSFORMING GROWTH FACTOR BETA;

BLOOD VESSEL TONE; CONFERENCE PAPER; DRUG SELECTIVITY; ENZYME ACTIVATION; FIBROSING ALVEOLITIS; HUMAN; ISCHEMIC HEART DISEASE; KIDNEY DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PULMONARY HYPERTENSION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; SYSTEMIC SCLEROSIS;

EID: 69949117326     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ken274     Document Type: Conference Paper

References (10)

1. Brand M, Le Moullec JM, Corvol P, Gasc JM. Ontogeny of endothelins-1 and -3, their receptors, and endothelin converting enzyme-1 in the early human embryo. J Clin Invest 1998;101:549-59.
2. Wilson SH, Simari RD, Lerman A. The effect of endothelin-1 on nuclear factor kappa B in macrophages. Biochem Biophys Res Commun 2001;286:968-72.
3. Harada N, Himeno A, Shigematsu K, Sumikawa K, Niwa M. Endothelin-1 binding to endothelin receptors in the rat anterior pituitary gland: possible formation of an ETA-ETB receptor heterodimer. Cell Mol Neurobiol 2002;22:207-26.
4. Lehrke I, Waldherr R, Ritz E, Wagner J. Renal endothelin-1 and endothelin receptor type B expression in glomerular diseases with proteinuria. J Am Soc Nephrol 2001;12:2321-9.
5. Abraham DJ, Vancheeswaran R, Dashwood MR et al. Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease. Am J Pathol 1997;151:831-41.
6. Minchenko AG, Stevens MJ, White L et al. Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. FASEB J 2003;17:1514-6.
7. Wackenfors A, Emilson M, Ingemansson R et al. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Eur J Pharmacol 2004;484:103-9.
8. Granstrom BW, Xu CB, Nilsson E, Bengtsson UH, Edvinsson L. Up-regulation of endothelin receptor function and mRNA expression in airway smooth muscle cells following sephadex-induced airway inflammation. Basic Clin Pharmacol Toxicol 2004;95:43-8.
9. Sasser JM, Sullivan JC, Hobbs JL et al. Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism. J Am Soc Nephrol 2007;18:143-54.
10. Shi-Wen X, Denton CP, Dashwood MR et al. Fibroblast matrix gene expression and connective tissue remodeling: Role of endothelin-1. J Invest Dermatol 2001; 116:417-25.