Imaging Protoporphyrin IX Fluorescence with a time-domain FMT/microCT system

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 7171, Issue , 2009, Pages

  Leblond, Frederic ^a   Kepshire, Dax ^a   Ohara, Julia A ^a   Dehghani, Hamid ^b   Srinivasan, Subha ^a   Mincu, N ^c   Hutchins, M ^c   Khayat, M ^c   Pogue, B W ^a  

^a DARTMOUTH COLLEGE   (United States)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c ART Advanced Research Technologies Inc   (Canada)

Author keywords

Diffuse optical imaging; Diffusion theory; Fluorescence; Light transport modeling; Molecular imaging; Near infrared imaging; Tomography

Indexed keywords

DIFFUSE OPTICAL IMAGING; DIFFUSION THEORY; LIGHT TRANSPORT MODELING; MOLECULAR IMAGING; NEAR-INFRARED IMAGING;

FLUOROPHORES; IMAGE RECONSTRUCTION; IMAGING SYSTEMS; INFRARED DEVICES; OPTICAL IMAGE STORAGE; OPTICAL SYSTEMS; TIME DOMAIN ANALYSIS; TOMOGRAPHY;

THERMOGRAPHY (IMAGING);

EID: 69949111081     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.809267     Document Type: Conference Paper

References (19)

1. D. Kepshire, N. Mincu, M. Hutchins, J. Gruber, H. Dehghani, J. Hypnarowski, F. Leblond, M. Khayat and B. W. Pogue, "A MicroCT Guided Fluorescence Tomography System for Small Animal Molecular Imaging", submitted to Review of Scientific Instruments, (2008).
2. A. Garofalakis, G. Zacharakis, H. Meyer, N. Economou, C. Mamalaki, J. Papamatheakis, D. Kioussis, V. Ntziachristos and J. Ripoll, "Three- Dimensional In Vivo Imaging of Green Fluorescent Protein-Expressing T Cells in Mice with Noncontact Fluorescence Molecular Tomography", Molecular Imaging, 6, 96-107 (2007).
3. G. Zacharakis, H. Shih, J. Ripoll, R. Weissleder and V. Ntziachristos, "Normalized Transillumination of Fluorescent Proteins in Small Animals", Molecular Imaging, 5, 153-59 (2006).
4. V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, Jr., L. Josephson and R. Weissleder, "Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate", Proceedings of the National Academy of Sciences of the United States of America, 101, 12294-9 (2004).
5. V. Ntziachristos, C.-H. Tung, C. Bremer and R. Weissleder, "Fluorescence molecular tomography resolves protease activity in vivo", Nature Medicine, 8, 757-60 (2002).
6. M. R. Hamblin and P. Mroz, [Advances in photodynamic therapy: basic, translational, and clinical], Boston & London, 495-505 (2008).
7. W. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestler, F. Zanella, H. J. Reulen and A. L.-G. S. Group, "Fluorescenceguided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial", Lancet Oncology, 7, 392-401 (2006).
8. W. Stummer, S. Stocker, A. Novotny, A. Heimann, O. Sauer, O. Kempski, N. Plesnila, J. Wietzorrek and H. J. Reulen, "In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid", Journal of Photochemistry & Photobiology. B - Biology., 45, 160-9 (1998).
9. W. Stummer, S. Stocker, S. Wagner, H. Stepp, C. Fritsch, C. Goetz, A. E. Goetz, R. Kiefmann and H. J. Reulen, "Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence", Neurosurgery, 42, 518-25; discussion 25-6 (1998).
10. D. Kepshire, N. Mincu, M. Hutchins, F. Leblond, B. W. Pogue and M. Khayat, "Design Considerations for a combined MicroCT and Fluorescence Diffuse Optical Tomography System", Biomedical Optics Proceedings, BSuE82 (2008).
11. H. Dehghani, B. W. Pogue, S. Jiang, B. Brooksby and K. D. Paulsen, "Three Dimensional Optical Tomography : Resolution in Small Object Imaging", Applied Optics, 42, 135-45 (2003).
12. H. Dehghani, B. A. Brooksby, K. Vishwanath, B. W. Pogue and K. D. Paulsen, "The effects of internal refractive index variation in near-infrared optical tomography: the finite element modeling approach", Physics in Medicine and Biology, 48, 2713-27 (2003).
13. V. Ntziachristos and R. Weissleder, "Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation", Optics Letters, 26, 893-95 (2001).
14. A. Soubret, J. Ripoll and V. Ntziachristos, "Accuracy of fluorescent tomography in the presence of heterogeneities: Study of the normalized born ratio", Ieee Transactions on Medical Imaging, 24, 1377-86 (2005).
15. F. Leblond, N. Mincu, N. Robitaille, S. Fortier, M. Khayat and B. W. Pogue, "Why acquiring excitation data improves the quality of reconstructed fluorescence images for highly heterogeneous diffusive media", Biomed. Optics Proc., OSA (2008).
16. F. Leblond, S. Fortier and M. P. Friedlander, "Diffuse optical fluorescence tomography using data acquired in transmission", Diffuse Optical IMaging of Tissue, SPIE Europe, The International Society for Optical Engineering, 6629(2007).
17. P. C. Hansen, [Rank-Deficient and Discrete Ill-Posed Problems], Society for Industrial and Applied Mathematics, Philadephia, 1998.
18. S. R. Arridge, van der Zee, P., Cope, M., Delpy, D. T., "Reconstruction methods for infrared absorption imaging", Proc. SPIE, 1431, 204-15 (1991).
19. M. Gao, G. Lewis, G. M. Turner, A. Soubret and V. Ntziachristos, "Effects of background fluorescence in fluorescence molecular tomography", Applied Optics, 44, 5468-74 (2005).