Pharmacologic options to prevent postoperative ileus

Annals of Pharmacotherapy

Volumn 43, Issue 9, 2009, Pages 1474-1485

  Yeh, Yu Chen ^a   Klinger, Elissa V ^a   Reddy, Prabashni ^a  

^a PARTNERS HEALTHCARE   (United States)

Author keywords

Alvimopan; Gum chewing; Ileus; Postoperative

Indexed keywords

17 METHYLNALTREXONE; ALBUMIN; ALGINIC ACID; ALVIMOPAN; BISACODYL; ERYTHROMYCIN; ESCIN; METOCLOPRAMIDE; MOSAPRIDE CITRATE; OPIATE; PLACEBO; PROPRANOLOL;

ABDOMINAL PAIN; ALLERGIC REACTION; ATELECTASIS; BRONCHITIS; CHEWING GUM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; COST BENEFIT ANALYSIS; DATA BASE; DEFECATION; DRUG DOSE COMPARISON; DRUG ERUPTION; DRUG MECHANISM; DRUG SAFETY; DYSTONIA; FEVER; FLATULENCE; FOOD INTAKE; HEART ARRHYTHMIA; HEART INFARCTION; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; ILEUS; INTESTINAL DYSMOTILITY; INTESTINE RESECTION; LENGTH OF STAY; LYMPHOCELE; MASTICATION; NAUSEA; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PULSE RATE; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; RESPIRATORY FAILURE; RESTLESSNESS; REVIEW; SEDATION; SIDE EFFECT; STOMACH INTUBATION; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; URINARY TRACT INFECTION; VOMITING;

CHEWING GUM; CLINICAL TRIALS AS TOPIC; DRUG COSTS; GASTROINTESTINAL AGENTS; HUMANS; ILEUS; PIPERIDINES; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS;

EID: 69949103713     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1M121     Document Type: Review

References (52)

1. Holte K, Foss NB, Andersen J, et al. Liberal or restrictive fluid administration in fast-track colonic surgery: a randomized, double-blind study. Br J Anaesth 2007;99:500-508 (Pubitemid 47412491)
2. Maron DJ, Fry RD. New therapies in the treatment of postoperative ileus after gastrointestinal surgery. Am J Ther 2008;15:59-65.
3. Saunders WB, Bowers B, Moss B, Bell TJ, Wang PF. Recorded rate and economic burden associated with postoperative ileus (abstract 30346). Presented at: American Society of Health-System Pharmacists Midyear Clinical Meeting, Orlando, FL, December 7, 2004.
4. Schmitt SL, Cohen SM, Wexner SD, Nogueras JJ, Jagelman DG. Does laparoscopic-assisted ileal pouch anal anastomosis reduce length of hospitalization. In J Colorectal Dis 1994;9:134-137
5. Artinyan A, Nunoo-Mensah JW, Balasubramaniam S, et al. Prolonged postoperative ileus - definition, risk factors, and predictors after surgery. World J Surg 2008;32:1495-1500
6. Senagore AJ. Pathogenesis and clinical and economic consequences of postoperative ileus. Am J Health Syst Pharm 2007;64(suppl):S3-7.
7. Iyer S, Saunders W. Burden of postoperative ileus (POI) in colectomy surgery patients in the United States. Presented at: International Society of Pharmacoeconomics and Outcomes Research Annual International Meeting, Arlington, VA, May 2007.
8. Charoenkwan K, Phillipson G, Vtyavanich T. Early versus delayed (traditional) oral fluids and food for reducing complications after major gynecological surgery. Cochrane Database Syst Rev 2007:CD004508. (Pubitemid 351805218)
9. Liu SS, Wu CL. Effect of postoperative analgesia on major postoperative complications: a systematic update of the evidence. Anesth Analg 2007;104:689-702. (Pubitemid 46309897)
10. Maffezzini M, Gerbi G, Campodonico F, Parodi D. Multimodal perioperative plan for radical cystectomy and intestinal diversion. I. Effect on recovery of intestinal function and occurrence of complications. Urology 2007;69:1107-1111
11. Schlachta CM, Burpee SE, Fernandez C, Chan B, Mamazza J, Poulin EC. Optimizing recovery after laparoscopic colon surgery (ORAL-CS). Surg Endosc 2007;21:2212-2219
12. Basse L, Jakobsen DH, Billesbølle, Werner M, Kehlet H. A clinical pathway to accelerate recovery after colonic resection. Ann Surg 2000;232:51-57 (Pubitemid 30456550)
13. Jørgensen H, Wetterslev J, Møiniche S, Dhal JB. Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, PONV, and pain after abdominal surgery. Cochrane Database Syst Rev 2001:CD001893.
14. Woods MS , Kelley H. Oncotic pressure, albumin and ileus: the effect of albumin replacement on postoperative ileus. Am Surg 1993;59:758-776 (Pubitemid 23320104)
15. Hallerback B, Carlsen E, Carlsson K, et al. β-Adrenoreceptor blockade in the treatment of postoperative adynamic ileus. Scand J Gastroenterol 1987;22:149-155 (Pubitemid 17024397)
16. Lightfoot AJ, Eno M, Kreder KJ, O'Donnell MA, Rao SSC, Williams RD. Treatment of postoperative ileus after bowel surgery with low-dose intravenous erythromycin. Urology 2007;69:611-615 (Pubitemid 46574920)
17. Smith AJ, Nissan A, Lanouette NM, et al. Prokinetic effect of erythromycin after colorectal surgery: randomized, placebo-controlled, double-blind study. Dis Colon Rectum 2000;43:333-337 (Pubitemid 30158569)
18. Bonacini M, Quiason S, Reynolds M, Gaddis M, Pemberton B, Smith O. Effect of erythromycin on postoperative ileus. Am J Gastroenterol 1993;88:208-211
19. de Castro SM, van den Esshert JW, van Heek NT, et al. A systematic review of the efficacy of gum chewing for the amelioration of postoperative ileus. Dig Surg 2008;25:39-45.
20. Chan MK, Law WL. Use of chewing gum in reducing postoperative ileus after elective colorectal resection: a systematic review. Dis Colon Rect 2007;50:2149-2157
21. McCormick JT, Garvin R, Caushaj P, et al. The effects of gum-chewing on bowel function and hospital stay after laparoscopic vs open colectomy: a multi-institution prospective randomized trial. J Am Coll Surg 2005;201(suppl):S66-7.
22. Cheape JD, Wexner SD, James K, Jagleman DG. Does metoclopramide reduce the length of ileus after colorectal surgery? A prospective randomized trial. Dis Colon Rectum 1991;34:437-441
23. Tollesson PO, Cassuto J, Faxén A, Rimbäck G, Mattsson E, Rosén S. Lack of effect of metoclopramide on colonic motility after cholecystectomy. Eur J Surg 1991;157:355-358
24. Jepsen S, Klærke, Nielsen PH, Simonsen O. Negative effect of metoclopramide in postoperative adynamic ileus. A prospective, randomized, double-blind study. Br J Surg 1986;73:290-291 (Pubitemid 16051047)
25. Davidson ED, Hersh T, Brinner RA, Barnett SM, Boyle LP. The effects of metoclopramide on postoperative ileus: a randomized, double-blind study. Ann Surg 1979;190:27-30. (Pubitemid 9247312)
26. Breivik H, Lind B. Anti-emetic and propulsive peristaltic properties of metoclopramide. Br J Anaesth 1971;43:400-403
27. Kivalo I, Miettinen K. The effects of metoclopramide on postoperative nausea and bowel function. Ann Chirug Gynaecol Fenniae 1970;59:155-158
28. Viscusi E, Rathmell J, Fichera A, et al. A double-blind, randomized, placebo-controlled trial of methylnaltrexone (MNTX) for post-operative bowel dysfunction in segmental colectomy patients (abstract 893). Presented at: American Society of Anesthesiologists Annual Meeting, Orlando, FL, October 24, 2005.
29. Progenics Pharmaceuticals, Inc. and Wyeth Pharmaceuticals, Inc. Progenics and Wyeth initiate global phase 3 clinical program of intravenous methylnaltrexone to treat post-operative ileus. September 20, 2006. Press release. www.wyeth.com/news/archive?nav=display&navTo=/wyeth-html/home/news/ pressreleases/2006/1158761833879.html (accessed 2009 Mar 20).
30. Progenics Pharmaceuticals, Inc. and Wyeth Pharmaceuticals, Inc. Wyeth and Progenics provide update on phase 3 clinical trial of intravenous methylnaltrexone for postoperative ileus. March 12, 2008. Press Release. www.wyeth.com/news/archive?nav=display&navTo=/wyeth-html/home/news/ pressreleases/2008/1205322072160.html (accessed 2009 Mar 20).
31. Progenics Pharmaceuticals, Inc. and Wyeth Pharmaceuticals, Inc. Wyeth and Progenics announce preliminary clinical trial results for Relistor oral and intravenous formulations. May 22, 2008. Press Release. www.wyeth.com/news/ archive?nav=display&navTo=/wyeth-html/home/news/pressreleases/2008/ 1211465152818.html (accessed 2009 Mar 20).
32. Senagore AJ, Bauer JJ, Du W, Techner L. Alvimopan accelerates gastrointestinal recovery after bowel resection regardless of age, gender, race, or concomitant medication use. Surgery 2007;142:478-486 (Pubitemid 47575582)
33. Zingg U, Miskovic D, Pasternak I, Meyer P, Hamel CT, Metzger U. Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial. Int J Colorectal Dis 2008;23:1175-1183
34. Xie Q, Zong X, Ge B, et al. Pilot postoperative ileus study of escin in cancer patients after colorectal surgery. World J Surg 2009;33:348-354
35. Narita K, Tsunoda A, Takenaka K, Watanabe M, Nakao K, Kusano M. Effect of mosapride on recovery of intestinal motility after hand-assisted laparoscopic colectomy for carcinoma. Dis Colon Rectum 2008;51:1692-1695
36. NDA 21-775 - review for regulatory action. May, 2008. www.fda.gov/cder/foi/nda/2008/021775-ENTEREG-CAPSULES-MEDR.pdf (accessed 2009 Apr 30).
37. Product information. Entereg (alvimopan) capsules. Research Triangle Park, NC, and Exton, PA: GlaxoSmithKline and Adolor Corporation, May 2008.
38. Abrahamsson H, Lyrenäs E, Dotevall G. Effects of beta-adrenoceptor blocking drugs on human sigmoid colonic motility. Dig Dis Sci 1983;28:590-594
39. Peeters TL. Erythromycin and other macrolides as prokinetic agents. Gastroenterology 1993;105:1886-1899
40. DiBaise JK, Quigley EM. Efficacy of prolonged administration of intravenous erythromycin in an ambulatory setting as treatment of severe gastroparesis: one center's experience. J Clin Gastroenterol 1999;28:131-134
41. Hirayama I, Suzuki M, Ide M, Asao T, Kuwano H. Gum chewing stimulates bowel motility after surgery for colorectal cancer. Hepato-Gastroenterology 2006; 53:206-208
42. Matros E, Rocha F, Zinner M, et al. Does gum chewing ameliorate postoperative ileus? Results of a prospective, randomized, placebo-controlled trial. J Am Coll Surg 2006;202:773-778
43. Quah HM, Samad A, Neathey AJ, Hay DJ, Maw A. Does gum chewing reduce postoperative ileus following open colectomy for left-sided colon and rectal cancer? A prospective randomized controlled trial. Colorect Dis 2006;8:64-70. (Pubitemid 43372262)
44. CVS Pharmacy Store. www.cvscom (accessed 2009 May 7).
45. Kilbinger H, Weibrauch TR. Drugs increasing gastrointestinal motility. Pharmacology 1982;25:61-72.
46. Product information. Relistor (methylnaltrexone bromide). Philadelphia, PA, and Tarrytown, NY: Wyeth and Progenics Pharmaceuticals, April 2008.
47. Seta ML, Kale-Pradhan PB. Efficacy of metoclopramide in postoperative ileus after exploratory laparotomy. Pharmacotherapy 2001;21:1181-1186
48. Thomas J, Karver S, Cooney GA, et al. Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med 2008;358:2332-2343 (Pubitemid 351749157)
49. Slatkin N, Thomas J, Lipman AG, et al. Methylnaltrexone for treatment of opioid-induced constipation in advanced illness patients. J Support Oncol 2009;7:39-46.
50. Salvador CG, Sikirica M, Evans E, Pizzi L, Goldfarb N. Clinical and economic outcomes of patients with prolonged postoperative ileus undergoing hysterectomy and hemicolectomy. P&T 2005;30:590-595 (Pubitemid 41606996)
51. Kehlet H, Büchler MW, Beart RW, Billingham RP, Williamson R. Care after colonic operation - is it evidence-based? Results from a multinational survey in Europe and the United States. J Am Coll Surg 2006;202:45-54. (Pubitemid 41831473)
52. Slim K, Vicaut E, Panis Y, Chipponi J. Meta-analysis of randomized clinical trials of colorectal surgery with or without mechanical bowel preparation. Br J Surg 2004;91:1125-1130 (Pubitemid 39179454)