Mitochondrial death channels in heart attacks, cells die if they aren't -perfused with fresh oxygen-and kill themselves if they are. Understanding cell suicide may greatly improve outcomes

American Scientist

Volumn 97, Issue 5, 2009, Pages 384-391

  Webster, Keith A ^a,b,c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c Department of Vascular Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CARDIOVASCULAR DISEASE; CYTOPLASM; MITOCHONDRION; PERMEABILITY;

EID: 69949102241     PISSN: 00030996     EISSN: None     Source Type: Trade Journal    
DOI: 10.1511/2009.80.384     Document Type: Article

References (6)

1. Anversa, P., and J. Kajstura. 2001. Myocyte cell death in the diseased heart. Circulatwn Research 82: 1231-1233.
2. Daniel, P. X., K. Schulze-Osthoff, C. Belka, and D. Guner. 2003. Guardians of cell death: the Bcl-2 family proteins. Essays in Biochemistry 39: 73-88.
3. Giordano, F. J. 2005. Oxygen, oxidative stress, hypoxia, and heart failure. Journal of Clinical Investigation 115: 500-508.
4. Green, D. R., and J. C. Reed. 1989. Mitochondria and apoptosis. Science 281: 309-312.
5. Webster, K. A., and N. H. Bishopric. 2003. Apoptosis inhibitors for heart disease. Circulation 108: 2954-2956.
6. Webster, K. A. 2007. Programmed death as a therapeutic target to reduce myocardial infarction. Trends in Pharmacological Science 9: 492-499.