Time-dependent differential gene expression in lysophosphatidic acid-treated young and senescent human diploid fibroblasts

Mechanisms of Ageing and Development

Volumn 130, Issue 9, 2009, Pages 648-651

  Rhim, Ji Heon ^a   Jang, Ik Soon ^b   Choi, Jong Soon ^b   Kwon, Hyun Jin ^c   Yeo, Eui Ju ^c   Park, Sang Chul ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Gachon University   (South Korea)

Author keywords

cDNA microarray analysis; Differential gene expression; Human diploid fibroblasts; Lysophosphatidic acid; Senescent HDFs

Indexed keywords

ARGININE CARBOXYPEPTIDASE; CELL SURFACE PROTEIN; CHOLECYSTOKININ; COMPLEMENTARY DNA; CYSTEINE RICH PROTEIN 61; DUAL SPECIFICITY PHOSPHATASE 6; EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 3; FORKHEAD TRANSCRIPTION FACTOR; HIGH MOBILITY GROUP PROTEIN; HISTONE; INTERLEUKIN 8; LYSOPHOSPHATIDIC ACID; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL RIBOSOME RECYCLING FACTOR; PROTEIN F3; PROTEIN KINASE C BETA; SERINE PROTEINASE INHIBITOR; SPHINGOSINE KINASE 1; THROMBOPLASTIN; TRANSGELIN; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CELL AGING; DIPLOIDY; FIBROBLAST; GENE EXPRESSION PROFILING; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TIME; UPREGULATION;

CELL AGING; CELLS, CULTURED; DIPLOIDY; DNA, COMPLEMENTARY; FIBROBLASTS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; LYSOPHOSPHOLIPIDS; MICROARRAY ANALYSIS; TIME FACTORS;

EID: 69949091956     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2009.06.007     Document Type: Article

References (23)

1. Chen C.C., Mo F.E., and Lau L.F. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J. Biol. Chem. 276 (2001) 47329-47337
2. Chen Y., and Du X.Y. Functional properties and intracellular signaling of CCN1/Cyr61. J. Cell Biochem. 100 (2007) 1337-1345
3. Cui M.Z., Laag E., Sun L., Tan M., Zhao G., and Xu X. Lysophosphatidic acid induces early growth response gene 1 expression in vascular smooth muscle cells: CRE and SRE mediate the transcription. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 1029-1035
4. Cui M.Z., Zhao G., Winokur A.L., Laag E., Bydash J.R., Penn M.S., Chisolm G.M., and Xu X. Lysophosphatidic acid induction of tissue factor expression in aortic smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 224-230
5. Fukushima N., Ishii I., Contos J.J., Weiner J.A., and Chun J. Lysophospholipid receptors. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 507-534
6. Jang I.S., Yeo E.J., Park J.A., Ahn J.S., Park J.S., Cho K.A., Juhnn Y.S., and Park S.C. Altered cAMP signaling induced by lysophosphatidic acid in senescent human diploid fibroblasts. Biochem. Biophys. Res. Commun. 302 (2003) 778-784
7. Kamimura M., Bea F., Akizawa T., Katus H.A., Kreuzer J., and Viedt C. Platelet-derived growth factor induces tissue factor expression in vascular smooth muscle cells via activation of Egr-1. Hypertension 44 (2004) 944-951
8. Kim H.S., Song M.C., Kwak I.H., Park T.J., and Lim I.K. Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J. Biol. Chem. 278 (2003) 37497-37510
9. Kim N.H., Ahn Y., Oh S.K., Cho J.K., Park H.W., Kim Y.S., Hong M.H., Nam K.I., Park W.J., Jeong M.H., Ahn B.H., Choi J.B., Kook H., Park J.C., Jeong J.W., and Kang J.C. Altered patterns of gene expression in response to chronic atrial fibrillation. Int. Heart J. 46 (2005) 383-395
10. Krones-Herzig A., Adamson E., and Mercola D. Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 3233-3238
11. Lener T., Moll P.R., Rinnerthaler M., Bauer J., Aberger F., and Richter K. Expression profiling of aging in the human skin. Exp. Gerontol. 41 (2006) 387-397
12. Lim I.K., Won Hong K., Kwak I.H., Yoon G., and Park S.C. Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts. Mech. Ageing Dev. 119 (2000) 113-130
13. Park W.Y., Hwang C.I., Kang M.J., Seo J.Y., Chung J.H., Kim Y.S., Lee J.H., Kim H., Kim K.A., Yoo H.J., and Seo J.S. Gene profile of replicative senescence is different from progeria or elderly donor. Biochem. Biophys. Res. Commun. 282 (2001) 934-939
14. Ragione F.D., Cucciolla V., Criniti V., Indaco S., Borriello A., and Zappia V. p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect. J. Biol. Chem. 278 (2003) 23360-23368
15. Sakamoto S., Yokoyama M., Zhang X., Prakash K., Nagao K., Hatanaka T., Getzenberg R.H., and Kakehi Y. Increased expression of CYR61, an extracellular matrix signaling protein, in human benign prostatic hyperplasia and its regulation by lysophosphatidic acid. Endocrinology 145 (2004) 2929-2940
16. Shelton D.N., Chang E., Whittier P.S., Choi D., and Funk W.D. Microarray analysis of replicative senescence. Curr. Biol. 9 (1999) 939-945
17. Si W., Kang Q., Luu H.H., Park J.K., Luo Q., Song W.X., Jiang W., Luo X., Li X., Yin H., Montag A.G., Haydon R.C., and He T.C. CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol. Cell. Biol. 26 (2006) 2955-2964
18. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 5116-5121
19. Yang M., Zhong W.W., Srivastava N., Slavin A., Yang J., Hoey T., and An S. G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 6027-6032
20. Yeo E.J., Hwang Y.C., Kang C.M., Kim I.H., Kim D.I., Parka J.S., Choy H.E., Park W.Y., and Park S.C. Senescence-like changes induced by hydroxyurea in human diploid fibroblasts. Exp. Gerontol. 35 (2000) 553-571
21. Yeo E.J., Jang I.S., Lim H.K., Ha K.S., and Park S.C. Agonist-specific differential changes of cellular signal transduction pathways in senescent human diploid fibroblasts. Exp. Gerontol. 37 (2002) 871-883
22. Yeo E.J., and Park S.C. Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging. Mech. Ageing Dev. 123 (2002) 1563-1578
23. Yoon I.K., Kim H.K., Kim Y.K., Song I.H., Kim W., Kim S., Baek S.H., Kim J.H., and Kim J.R. Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology. Exp. Gerontol. 39 (2004) 1369-1378