FOXP3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning

Immunologic Research

Volumn 44, Issue 1-3, 2009, Pages 179-184

  Dorsey, Morna J ^a   Petrovic, A ^a   Morrow, M R ^a   Dishaw, L J ^b   Sleasman, J W ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Immunodeficiency; Regulatory T cells; Transplantation

Indexed keywords

ALEMTUZUMAB; ANTIBIOTIC AGENT; ANTIHYPERTENSIVE AGENT; CD16 ANTIGEN; CD19 ANTIGEN; CD34 ANTIGEN; CD56 ANTIGEN; CONCANAVALIN A; CYCLOSPORIN; FLUDARABINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEMOGLOBIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INSULIN; MELPHALAN; MESSENGER RNA; METHOTREXATE; PHYTOHEMAGGLUTININ; POKEWEED MITOGEN; PREDNISONE; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3; ANTINEOPLASTIC AGENT; CANCER ANTIBODY; DRUG DERIVATIVE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 7 RECEPTOR ALPHA; MONOCLONAL ANTIBODY; VIDARABINE;

ALLELE; ALLERGY; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; AUTOIMMUNITY; BACTEREMIA; CASE REPORT; CATHETER REMOVAL; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CENTRAL VENOUS CATHETER; CHIMERA; COLITIS; COLON BIOPSY; CYTOLYSIS; DEHYDRATION; DERMATITIS; DIARRHEA; ECZEMA; ELECTROLYTE DISTURBANCE; EMERGENCY WARD; ENGRAFTMENT; ENTERITIS; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE INFECTION; EOSINOPHIL COUNT; FAILURE TO THRIVE; FEEDING DISORDER; FLOW CYTOMETRY; GASTROENTEROLOGY; GENE MUTATION; GRAFT VERSUS HOST REACTION; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; HYPERTENSION; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSUPPRESSIVE TREATMENT; INFANT; INTRAVENOUS ADMINISTRATION; IPEX SYNDROME; KARYOTYPE 46,XY; LEUKOCYTE COUNT; LYMPHOCYTE; MALE; MUTATIONAL ANALYSIS; NATURAL KILLER CELL; NEUTROPHIL; PHENOTYPE; POINT MUTATION; POLYADENYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; QUANTITATIVE ASSAY; REDUCED INTENSITY CONDITIONING; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; SKIN DISEASE; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS INFECTION; THROMBOCYTE; TOTAL PARENTERAL NUTRITION; VAGINAL DELIVERY; VOMITING; AUTOIMMUNE DISEASE; BIOSYNTHESIS; BLOOD; BONE MARROW TRANSPLANTATION; DRUG EFFECT; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; METABOLISM; X LINKED SEVERE COMBINED IMMUNODEFICIENCY;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; ANTINEOPLASTIC AGENTS; AUTOIMMUNE DISEASES; BONE MARROW TRANSPLANTATION; FORKHEAD TRANSCRIPTION FACTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOGLOBULIN E; INFANT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MALE; MELPHALAN; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION CONDITIONING; VIDARABINE; X-LINKED COMBINED IMMUNODEFICIENCY DISEASES;

EID: 69849108052     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-009-8112-y     Document Type: Article

References (9)

1. RS Wildin S Smyk-Pearson AH Filipovich 2002 Clinical and molecular features of immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome J Med Genet 39 537 545 12161590 10.1136/jmg.39.8.537 1:CAS:528:DC%2BD38XntFSktbs%3D
2. A Rao N Kamani A Filipovich S Molleran BS Lee SM Davies J Dalal S Shenoy 2007 Successful bone marrow transplantation for IPEX syndrome following reduced intensity conditioning Blood 109 1 383 385 16990602 10.1182/blood-2006-05-025072 1:CAS:528:DC%2BD2sXivVyqsr0%3D (Pubitemid 46053081)
3. D Moraes-Vasconcelos BT Costa-Carvalho TR Torgerson HD Ochs 2008 Primary immune deficiency disorders presenting as autoimmune diseases: IPEX and APECED J Clin Immunol 28 Suppl 1 S11 S19 18264745 10.1007/s10875-008-9176-5 1:CAS:528:DC%2BD1cXptFyqs7g%3D
4. HD Ochs SF Ziegler TR Torgerson 2005 FOXP3 acts as a rheostat of the immune response Immunol Rev 203 156 164 15661028 10.1111/j.0105-2896.2005.00231. x 1:CAS:528:DC%2BD2MXhvFyns7Y%3D (Pubitemid 40179700)
5. TR Torgerson HD Ochs 2002 Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulation Curr Opin Allergy Clin Immunol 2 481 487 14752330 10.1097/00130832-200212000-00002 (Pubitemid 36105810)
6. O Baud O Goulet D Canioni F Le Deist I Radford D Rieu S Dupuis-Girod N Cerf-Bensussan M Cavazzana-Calvo N Brousse A Fischer JL Casanova 2001 Treatment of the immune dysregulation, polyendocrinopathy, X-linked syndrome (IPEX) by allogeneic bone marrow transplantation N Eng J Med 344 23 1758 1762 10.1056/NEJM200106073442304 1:STN:280:DC%2BD3MzivVeiug%3D%3D (Pubitemid 32497030)
7. H Zhan J Sinclair S Adams C Cale S Murch L Perroni G Davies P Amrolia W Qasim 2008 Immune reconstitution and recovery of FOXP3-expression T cells after transplantation for IPEX syndrome Pediatrics 121 e998 e1002 18316354 10.1542/peds.2007-1863
8. X Chang JX Gao Q Jiang, et al. 2005 The scurfy mutation of FOXP3 in the thymus stroma leads to defective thymopoiesis J Exp Med 202 8 1141 1151 16230479 10.1084/jem.20050157 1:CAS:528:DC%2BD2MXhtFelu7vP (Pubitemid 41464507)
9. H Olkinuora K Talvensaari, et al. 2007 T cell regeneration in pediatric allogeneic stem cell transplantation Bone Marrow Transplant 39 149 156 17211435 10.1038/sj.bmt.1705557 1:CAS:528:DC%2BD2sXotFKksA%3D%3D (Pubitemid 46178749)