AIMing 2 detect foreign DNA

Science Signaling

Volumn 2, Issue 77, 2009, Pages

  Krieg, Arthur M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; EXTRACHROMOSOMAL DNA; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GENOMIC DNA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEIC ACID; PROTEIN AIM2; PROTEIN ASC; UNCLASSIFIED DRUG; AIM2 PROTEIN, HUMAN; BIOPOLYMER; DNA; NUCLEAR PROTEIN;

CELL DEATH; CYTOKINE RELEASE; CYTOPLASM; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION; ARTICLE; CHEMISTRY; METABOLISM;

BIOPOLYMERS; DNA; NUCLEAR PROTEINS;

EID: 69849101245     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.277pe39     Document Type: Review

References (23)

1. T. Kawai, S. Akira, The roles of TLRs, RLRs and NLRs in pathogen recognition. Int. Immunol. 21, 317-337 (2009).
2. K. J. Stacey, I. L. Ross, D. A. Hume, Electroporation and DNA-dependent cell death in murine macrophages. Immunol. Cell Biol. 71, 75-85 (1993).
3. T. L. Roberts, A. Idris, J. A. Dunn, G. M. Kelly, C. M. Burnton, S. Hodgson, L. L. Hardy, V. Garceau, M. J. Sweet, I. L. Ross, D. A. Hume, K. J. Stacey, HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323, 1057-1060 (2009).
4. T. Burckstummer, C. Baumann, S. Bluml, E. Dixit, G. Durnberger, H. Jahn, M. Planyavsky, M. Bilban, J. Colinge, K. L. Bennett, G. Superti-Furga, An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10, 266-272 (2009).
5. V. Hornung, A. Ablasser, M. Charrel-Dennis, F. Bauernfeind, G. Horvath, D. R. Caffrey, E. Latz, K. A. Fitzgerald, AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458, 514-518 (2009).
6. T. Fernandes-Alnemri, J.W.Yu, P. Datta, J.Wu, E. S. Alnemri, AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458, 509-513 (2009).
7. T. Tokunaga, H. Yamamoto, S. Shimada, H. Abe, T. Fukuda, Y. Fujisawa, Y. Furutani, O. Yano, T. Kataoka, T. Sudo, Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72, 955-962 (1984).
8. A. M. Krieg, A. K. Yi, S. Matson, T. J.Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, D. M. Klinman, CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546-549 (1995).
9. H. Hemmi, O.Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H.Wagner, K. Takeda, S. Akira, A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).
10. E. Latz, A. Schoenemeyer, A. Visintin, K. A. Fitzgerald, B. G. Monks, C. F. Knetter, E. Lien, N. J. Nilsen, T. Espevik, D. T. Golenbock, TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5, 190-198 (2004).
11. K. Suzuki, A. Mori, K. J. Ishii, J. Saito, D. S. Singer, D. M. Klinman, P. R. Krause, L. D. Kohn, Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc. Natl. Acad. Sci. U.S.A. 96, 2285-2290 (1999).
12. H. Yoshida, Y. Okabe, K. Kawane, H. Fukuyama, S. Nagata, Lethal anemia caused by interferonbeta produced in mouse embryos carrying undigestedDNA. Nat. Immunol. 6, 49-56 (2005).
13. K. J. Ishii, C. Coban, H. Kato, K. Takahashi, Y. Torii, F. Takeshita, H. Ludwig, G. Sutter, K. Suzuki, H. Hemmi, S. Sato, M. Yamamoto, S. Uematsu, T. Kawai, O. Takeuchi, S. Akira, A Toll-like receptor-independent antiviral response induced by doublestranded B-form DNA. Nat. Immunol. 7, 40-48 (2006).
14. D. B. Stetson, R. Medzhitov, Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24, 93-103 (2006).
15. A. Takaoka, Z. Wang, M. K. Choi, H. Yanai, H. Negishi, T. Ban, Y. Lu, M. Miyagishi, T. Kodama, K. Honda, Y. Ohba, T.Taniguchi, DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448, 501-505 (2007).
16. K. J. Ishii, T. Kawagoe, S. Koyama, K. Matsui, H. Kumar, T. Kawai, S. Uematsu, O. Takeuchi, F. Takeshita, C. Coban, S. Akira, TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451, 725-729 (2008).
17. D. A. Muruve, V. Petrilli, A. K. Zaiss, L. R. White, S. A. Clark, P. J. Ross, R. J. Parks, J. Tschopp, The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452, 103-107 (2008).
18. T. Liu, A. Rojas, Y. Ye, A. Godzik, Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family. Protein Sci. 12, 1872-1881 (2003).
19. S. Karlin, W. Doerfler, L. R. Cardon, Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? J. Virol. 68, 2889-2897 (1994).
20. D. Choubey, R. Panchanathan, Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunol. Lett. 119, 32-41 (2008).
21. A. R. Thierry, E. Vives, J. P. Richard, P. Prevot, C. Martinand-Mari, I. Robbins, B. Lebleu, Cellular uptake and intracellular fate of antisense oligonucleotides. Curr. Opin. Mol. Ther. 5, 133-138 (2003).
22. J. A. Wolff, V. Budker, The mechanism of naked DNA uptake and expression. Adv. Genet. 54, 3-20 (2005).
23. B. Spies, H. Hochrein, M. Vabulas, K. Huster, D. H. Busch, F. Schmitz, A. Heit, H. Wagner, Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J. Immunol. 171, 5908-5912 (2003).