Expression of p53, bcl-2 and nm23 proteins in squamous cell lung cancer;Ekspresja białek p53, bcl-2 i nm23 w płaskonabłonkowym raku płuca

Pneumonologia i Alergologia Polska

Volumn 77, Issue 2, 2009, Pages 131-137

  Porebska, Irena ^a   Kosacka, Monika ^a   Wyrodek, Ewa ^a   Jankowska, Renata ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Bcl 2; Immunohistochemlstry; Lung cancer; Nm23; P53

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE NM23; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TUMOR MARKER;

AGED; APOPTOSIS; ARTICLE; CHEMISTRY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; MALE; MIDDLE AGED; SQUAMOUS CELL CARCINOMA;

AGED; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 69849087521     PISSN: 08677077     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Szozuka I., Roszkowski-Śliź K. Rak płuca w Polsce w latach 1970-2004. Pneumonol. Alergol. Pol. 2008; 76: 19-28.
2. Soussi T. The p53 tumor suppressor gene: from molecular biology to clinical investigation. Ann NY Acad. Sci 2000; 910: 121-137.
3. Cory S., Huang C.S.D., Adams M.J. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22: 8590-8607.
4. Steeg P.S. Perspectives on classic article: metastasis suppressor genes. J. Natl. Cancer Inst. 2004; 96: E4.
5. Piyathilake J.Ch., Frost A.R., Mamie U., Weis H., Heimburger D.C., Grizzle W.E. Nuclear Accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers. Chest 2003; 123: 181-186.
6. Brambilla E., Travis W.D., Colby T.V., Corrin B., Shimosato Y., The new World Health Organization olassificantion of lung tumors. Eur. Respir. J. 2001; 18: 1059-1068.
7. Mountain C.F. Revisions in the international system, for staging lung cancer. Chest 1997; 111: 1710-1717.
8. Tsuchiya T., Hashizume S., Akamine S. i wsp. Upstaging by vessel invasion improves the pathology staging system of non-small cell lung cancer. Chest 2007; 132: 170-177.
9. Mitsudomi T., Oyama T., Nishida K. i wsp. P53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effect on patients survival. Ann. Oncol. 1995; 6: 9-13.
10. Moldvay J., Scheid P., Wild P. i wsp. Predictive survival markers in patients with surgically resected non-small cell lung carcinoma. Clin Cancer Res. 2000; 6: 1125-1134.
11. Lai R.S., Wang J.S., Hsu H.K., Chang H.C., Lin C.H., Lin M.H. Prognostic evaluation of the expression of p53 and bcl-2 oncoproteins in patients with surgically resected non-small cell lung cancer. Jpn. J. Clin Oncol. 2002; 32: 393-397.
12. Mitsudomi T., Hamajima N., Ogawa M., Takahashi T. Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis. Clin Cancer Res. 2000; 6: 4055-4063.
13. Ohmura Y., Aoe M., Andou A., Shimizu N. Telomerase activity and bcl-2 expression in non-small cell lung cancer. Clin. Cancer Res. 2000; 6: 2980-2987
14. Hainaut P., Pfeifer G.P. Patterns of p53 G→T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. Carcinogenesis 2001; 22: 367-374.
15. Yaren A., Oztop L, Kargi A. i wsp. Bax, bcl-2 and c-kit expression in non-small-cell lung cancer and their effects on prognosis. Int. J. Clin Pract. 2006; 60: 674-682.
16. Ohta Y., Nozaki Z., Nozawa H. i wsp. The predictive value of vascular endothelial growth factor and mn23 for the diagnosis of occult metastasis in non-small cell lung cancer Jpn. J. Cancer Res. 2001; 92: 361-366.
17. Polláii M., Varela G., Torres A. i wsp. Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer. Int. J. Cancer 2003; 10: 781-790.
18. Groeger A.M., Esposito V., De Luca A. i wsp. Prognostic value of immunohistochemical expression of p53, bax, Bcl-2 and Bcl-x in resected non-small cell lung cancers. Histopathology 2004; 44: 54-63.
19. Bosnar M.H., Pavelic K., Krizanac S., Slobodnjak Z., Pavelio J. Squamous cell lung carcinomas: the role of nm23-H1 gene. J. Moll Med. 1997; 75: 609-613.
20. Lai W.W., Wu M.H., Yan J.J., Chen F.F. Immunohistochemical analysis of nm23-H1 in stage I non-small cell lung cancer: a useful, marker in prediction of metastasis. Ann. Thorac. Surg. 1996; 62: 1500-1504.
21. Chen X.F., Zhang H.T., Qi Q.Y., Sun M.M., Tao L.Y. Expression of E-cadherin and nm23 is associated with the clinicopathological factors of human non-small cell lung cancer in China. Lung Cancer 2005; 48: 69-76.
22. Kogan E.A., Shvets S.I., Kovalenko V.L., Soboleva Iu.V. Correlation of proliferation, apoptosis, angiogenesis and metastasing in various histogenetic types of pulmonary cancer (an immunohistochemical investigation). Arkh. Fatol. 2004; 66: 33-38.
23. Faran G., Dworakowska D., Jassem E. Kliniczne znaczenie immunohistoohemicznej ekspresji bialek p53, Bcl-2 i Bax u chorych na niedrobnokomórkowego raka płuca. Wspńłczesna Onkologia 2004; 8: 328-337.
24. Tang X.j., Zhou Q.H., Zhang S.F., Liu L.X. Expressions of nm23, E-cadherin, and beta-catenin in non-small cell lung cancer and their correlations with metastasis and prognosis. Ai Zheng 2005; 24:616-621.
25. Tomita M., Ayabe T., Matsuzaki Y., Onitsuka T. Immunohi-stochemical analysis of nm23-H1 gene produkt in node-positive lung cancer and lymph nodes. Lung Cancer 1999; 24: 11-16.
26. Hsu N.Y., Chen C.Y., Hsu C.P. i wsp. Prognostic significance of expression of nm.2 3-H1 and focal adhesion kinase in non-small lung cancer. Oncol. Rep. 2007; 18: 81-85.
27. Walker C., Robertson L., Myskow M.W., Dixon G.R. Expression of the BCL-2 protein in normal and dysplastic bronchial epithelium and in lung carcinomas. Br. J. Cancer 1995; 72: 164-169.
28. Porçbska I., Wyrodek E., Jankowska R., Kosacka M., Harłozińska-Szmyrka A. Apoptotic markers: p53, bcl-2 and bax in primary lung cancer. In Vivo 2006; 20: 599-604.