Squamous cell lung carcinomas: The role of nm23-H1 gene

Journal of Molecular Medicine

Volumn 75, Issue 8, 1997, Pages 609-613

  Bosnar, Maja Herak ^a,b   Pavelić, Krešimir ^b   Križanac, Šimun ^e   Slobodnjak, Zoran ^f   Pavelić, Jasminka ^a,b,c,d  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

^c University of Zagreb ^*

^d Division of Physical Chemistry   (Croatia)

^e UNIVERSITY OF ZAGREB   (Croatia)

^f KBC Zagreb   (Croatia)

Author keywords

Nm23 H1 gene; Squamous cell lung carcinomas

Indexed keywords

DNA; NUCLEOSIDE DIPHOSPHATE KINASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; LUNG CARCINOMA; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

AGED; CARCINOMA, SQUAMOUS CELL; DINUCLEOTIDE REPEATS; DNA, NEOPLASM; GENES, NEOPLASM; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MALE; MIDDLE AGED; MONOMERIC GTP-BINDING PROTEINS; NUCLEOSIDE-DIPHOSPHATE KINASE; POLYMORPHISM, GENETIC; TRANSCRIPTION FACTORS;

EID: 0030875735     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050146     Document Type: Article

References (18)

1. Steeg PS, Bevilucqua G, Kopper L, Thorgeirsson UP, Talmadge JE, Liotta LA, Sobel ME (1988) Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 80:200-204
2. Ozeki Y, Takishima K, Mamiya G (1994) Immunohistochemical analysis of nm23/NDP kinase expression in human lung adenocarcinoma: association with tumor progression in Clara cell type. Jpn J Cancer Res 85:840-846
3. Engel M, Theisinger B, Seib T, Seitz G, Huwer H, Zang KD, Welter C, Dooley S (1993) High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages. Int J Cancer 55:375-379
4. Higashiyama M, Doi O, Yokouchi H, Kodama K, Nakamori S, Tateishi R, Kimura N (1992) Immunohistochemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value. Br J Cancer 66: 533-536
5. Leone A, McBride OW, Weston A, Wang MG, Anglard P, Cropp CS, Goepel JR, Lidereau R, Callahan R, Linehan WM, Rees RC, Harris CC, Liotta LA, Steeg PS (1991) Somatic allelic deletion of nm23 in human cancer. Cancer Res 51:2490-2493
6. Gazzeri S, Brambilla E, Negoescu A, Thoraval D, Veron M, Moro D, Brambilla C (1996) Overexpression of nucleoside diphosphate/kinase A/nm23-H1 protein in human lung tumors: association with tumor progression in squamous carcinoma. Lab Invest 74:158-167
7. Fong KM, Kida Y, Zimmerman PV, Ikenaga M, Smith PJ (1995) Loss of heterozygosity frequently affects chromosome 17q in non-small cell lung cancer. Cancer Res 55:4268-4272
8. Merlo A, Mabry M, Gabrielson E, Vollmer R, Baylin SB, Sidransky D (1994) Frequent microsatellite instability in primary small cell lung cancer. Cancer Res 54:2098-2101
9. Peltomaki P, Lothe RA, Aaltonen LA, Pylkkanen L, NystromLahti M, Seruca R, David L, Holm R, Ryberg D, Haugen A, Brogger A, Borresen A-L, de la Chapelle A (1993) Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res 53:5853-5855
10. Shridhar V, Siegfried J, Hunt J, del Mar Alonso M, Smith DI (1994) Genetic instability of microsatellite sequences in many non-small cell lung carcinomas. Cancer Res 54:2084-2087
11. Sambrook J, Fritsch RF, Maniatis T (1989) Molecular cloning. A laboratory manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor
12. Pavelic K, Pavelic ZP, Denton D, Reising J, Khalily M, Preisler HD (1990) Immunohistochemical detection of c-myc oncoprotein in paraffin embedded tissue. J Exp Pathol 5:143-153
13. Pavelic J, Gall-Trošelj K, Hlavka V, Pavelic ZP, Gluckman JL, Stambrook PJ, Pavelic K (1994) nm23-H1 protein in oligodendrogliomas. Int J Oncol 4:1399-1403
14. Hirayama R, Sawai S, Takagi Y, Mishima Y, Kimura N, Shimada N, Esaki Y, Kurashima C, Utsuyama M, Hirokawa K (1991) Positive relationship between expression of anti-metastatic factor (nm23 gene product or nucleoside diphosphate kinase) and good prognosis in human breast cancer. J Natl Cancer Inst 83:1249-1250
15. Kodera Y, Isobe K, Yamauchi M, Kondoh K, Kimura N, Akiyama S, Itoh K, Nakshima I, Takagi H (1994) Expression of nm23-H1 RNA levels in human gastric cancer tissues. Cancer 73:259-265
16. Yamagushi A, Urano T, Fushida S, Furukawa K, Nishimura G, Yonemura Y, Miyazaki I, Nakagawara G, Shiku H (1993) Inverse association of nm23-H1 expression by colorectal cancer with liver metastasis. Br J Cancer 68:1020-1024
17. Wang L, Patel U, Ghosh L, Chen HC, Banerjee S (1993) Mutation in the nm23 gene is associated with metastasis in colorectal cancer. Cancer Res 53:717-720
18. Florenes VA, Aamdal S, Myklebost O, Maelandsmo GM, Bruland OS, Fodstad O (1992) Levels of nm23 messenger RNA in metastatic melignant melanomas: inverse correlation to disease progression. Cancer Res 52:6088-6091