Effect of simvastatin on inflammatory reactions in cerebral vasospasm after subarachnoid hemorrhage in rabbits

Chinese Journal of Cerebrovascular Diseases

Volumn 6, Issue 8, 2009, Pages 413-418

  Duan, Hong Zhou ^a   Mo, Da Peng ^a   Li, Liang ^a   Zhang, Jia Yong ^a   Bao, Sheng De ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Inflammation; Rabbits; Reactive inhibition; Simvastatin; Subarachnoid hemorrhage; Vasospasm, intracranial

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERIAL WALL THICKNESS; ARTERY DIAMETER; ARTICLE; BASILAR ARTERY; BRAIN ANGIOGRAPHY; BRAIN VASOSPASM; CONTROLLED STUDY; ENDOTHELIUM CELL; HISTOPATHOLOGY; INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; SUBARACHNOID HEMORRHAGE; TISSUE STRUCTURE; VASCULAR ENDOTHELIUM;

EID: 69749126767     PISSN: 16725921     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1672-5921.2009.08.006     Document Type: Article

References (16)

1. Bederson JB, Connolly ES Jr, Batjer HH, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association[J]. Stroke, 2009,40(3):994-1025.
2. Macdonald RL. Management of cerebral vasospasm [J]. Neurosurg Rev, 2006,29(3):179-193.
3. Sugawara T, Ayer R, Jadhav V, et al. Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase[J]. J Neurosci Res, 2008, 86(16):3635-3643.
4. Lynch JR, Wang H, McGirt MJ, et al. Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial [J]. Stroke, 2005,36(9):2024-2026. (Pubitemid 41266547)
5. McGirt MJ, Pradilla G, Legnani FG, et al. Systemic administration of simvastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm [J]. Neurosurgery, 2006,58(5):945-951. (Pubitemid 43772438)
6. McGirt MJ, Lynch JR, Parra A, et al. Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage [J]. Stroke, 2002,33(12):2950-2956. (Pubitemid 35462871)
7. Crowley RW, Medel R, Kassell NF, et al. New insights into the causes and therapy of cerebral vasospasm following subarachnoid hemorrhage [J]. Drug Discov Today, 2008,13(5-6):254-260.
8. Wakade C, King MD, Laird MD, et al. Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice [J]. Antioxid Redox Signal, 2009,11(1):35-45.
9. Osuka K, Suzuki Y, Tanazawa T, et al. Interleukin-6 and development of vasospam after subarachnoid haemorrhage [J]. Acta Neurochir (Wien), 1998,140(9):943-951. (Pubitemid 28474664)
10. Zhou ML, Shi JX, Hang CH, et al. Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits [J]. J Cereb Blood Flow Metab, 2007,27(9):1583-1592.
11. Fraser CC. G protein-coupled receptor connectivity to NF-kappaB in inflammation and cancer [J]. Int Rev Immunol, 2008,27(5):320-350.
12. Mousa SA. Cell adhesion molecules: potential therapeutic & diagnostic implications [J]. Mol Biotechnol, 2008,38(1):33-40.
13. Sakowitz OW, Unterberg AW. Detecting and treating microvascular ischemia after subarachnoid hemorrhage [J]. Curr Opin Crit Care, 2006,12(2):103-111.
14. Chou SH, Smith EE, Badjatia N. A randomized, double-blind, placebo-controlled pilot study of simvastatin in aneurysmal subarachnoid hemorrhage [J]. Stroke, 2008,39(10):2891-2893.
15. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences [J]. Cell, 1986,46(5):705-716.
16. The Long-Term Intervention with Pravastatinin Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels[J]. N Engl J Med, 1998,339(19):1349-1357.