Pyruvate protects against experimental stroke via an anti-inflammatory mechanism

Neurobiology of Disease

Volumn 36, Issue 1, 2009, Pages 223-231

  Wang, Qing ^a,b   van Hoecke, Michael ^a   Tang, Xian Nan ^a   Lee, Hokyou ^a   Zheng, Zheng ^a   Swanson, Raymond A ^a   Yenari, Midori A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cerebral ischemia; Inflammation; Neuroprotection; Pyruvate; Stroke

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTIC ACID; LIPOPOLYSACCHARIDE; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; INFLAMMATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE;

ANIMALS; BODY WEIGHT; CELL COUNT; DISEASE MODELS, ANIMAL; ECTODYSPLASINS; ENCEPHALITIS; INFARCTION, MIDDLE CEREBRAL ARTERY; LACTIC ACID; LIPOPOLYSACCHARIDES; MALE; MATRIX METALLOPROTEINASE 9; MICROGLIA; MOTOR ACTIVITY; NERVOUS SYSTEM DISEASES; NEUTROPHIL INFILTRATION; PROTEIN-SERINE-THREONINE KINASES; PSYCHOMOTOR PERFORMANCE; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; TETRAZOLIUM SALTS;

EID: 69749111672     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.07.018     Document Type: Article

References (34)

1. Andrae U., Singh J., and Ziegler-Skylakakis K. Pyruvate and related alpha-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity. Toxicol. Lett. 28 (1985) 93-98
2. Bederson J.B., Pitts L.H., Tsuji M., Nishimura M.C., Davis R.L., and Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17 (1986) 472-476
3. Borlongan C.V., and Sanberg P.R. Elevated body swing test: a new behavioral parameter for rats with 6-hydroxydopamine-induced hemiparkinsonism. J. Neurosci. 15 (1995) 5372-5378
4. Conn A.R., and Steele R.D. Transport of alpha-keto analogues of amino acids across blood-brain barrier in rats. Am. J. Physiol. 243 (1982) E272-277
5. De Ryck M., Van Reempts J., Borgers M., Wauquier A., and Janssen P.A. Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke 20 (1989) 1383-1390
6. Deng H., Han H.S., Cheng D., Sun G.H., and Yenari M.A. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke 34 (2003) 2495-2501
7. Desagher S., Glowinski J., and Premont J. Pyruvate protects neurons against hydrogen peroxide-induced toxicity. J. Neurosci. 17 (1997) 9060-9067
8. Enerson B.E., and Drewes L.R. Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J. Pharm. Sci. 92 (2003) 1531-1544
9. Fong J.J., and Rhoney D.H. NXY-059: review of neuroprotective potential for acute stroke. Ann. Pharmacother. 40 (2006) 461-471
10. Gonzalez-Falcon A., Candelario-Jalil E., Garcia-Cabrera M., and Leon O.S. Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats. Brain. Res. 990 (2003) 1-7
11. Han H.S., Qiao Y., Karabiyikoglu M., Giffard R.G., and Yenari M.A. Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J. Neurosci. 22 (2002) 3921-3928
12. Han H.S., Karabiyikoglu M., Kelly S., Sobel R.A., and Yenari M.A. Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J. Cereb. Blood Flow Metab. 23 (2003) 589-598
13. Han Y., Englert J.A., Yang R., Delude R.L., and Fink M.P. Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. J. Pharmacol. Exp. Ther. 312 (2005) 1097-1105
14. Hua Y., Schallert T., Keep R.F., Wu J., Hoff J.T., and Xi G. Behavioral tests after intracerebral hemorrhage in the rat. Stroke 33 (2002) 2478-2484
15. Kim J.B., Yu Y.M., Kim S.W., and Lee J.K. Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain. Res. 1060 (2005) 188-192
16. Lee J.Y., Kim Y.H., and Koh J.Y. Protection by pyruvate against transient forebrain ischemia in rats. J. Neurosci. 21 (2001) RC171
17. Lee J.E., Yoon Y.J., Moseley M.E., and Yenari M.A. Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke. J. Neurosurg. 103 (2005) 289-297
18. Oldendorf W.H. Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids. Am. J. Physiol. 224 (1973) 1450-1453
19. Renard P., Ernest I., Houbion A., Art M., LeCalvez H., Raes M., and Remacle J. Development of a sensitive multi-well colorimetric assay for active NFkappaB. Nucleic Acids Res. 29 (2001) E21
20. Sheline C.T., Behrens M.M., and Choi D.W. Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis. J. Neurosci. 20 (2000) 3139-3146
21. Shen Z., Peedikayil J., Olson G.K., Siebert P.D., and Fang Y. Multiple transcription factor profiling by enzyme-linked immunoassay. Biotechniques 32 (2002) 1168-1177
22. Shuaib A., Lees K.R., Lyden P., Grotta J., Davalos A., Davis S.M., Diener H.C., Ashwood T., Wasiewski W.W., and Emeribe U. NXY-059 for the treatment of acute ischemic stroke. N. Engl. J. Med. 357 (2007) 562-571
23. Suh S.W., Aoyama K., Matsumori Y., Liu J., and Swanson R.A. Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment. Diabetes 54 (2005) 1452-1458
24. Suh S.W., Bergher J.P., Anderson C.M., Treadway J.L., Fosgerau K., and Swanson R.A. Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmet hyl)propyl]-1H-indole-2-carboxamide). J. Pharmacol. Exp. Ther. 321 (2007) 45-50
25. Tang X.N., Wang Q., Koike M.A., Cheng D., Goris M.L., Blankenberg F.G., and Yenari M.A. Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia. J. Nucl. Med. 48 (2007) 1822-1828
26. Ulloa L., Ochani M., Yang H., Tanovic M., Halperin D., Yang R., Czura C.J., Fink M.P., and Tracey K.J. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12351-12356
27. Wang G.J., Deng H.Y., Maier C.M., Sun G.H., and Yenari M.A. Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration and microglia/monocyte accumulation following experimental stroke. Neuroscience 114 (2002) 1081-1090
28. Wang Q., Tang X.N., and Yenari M.A. The inflammatory response in stroke. J. Neuroimmunol. 184 (2007) 53-68
29. Woo Y.J., Taylor M.D., Cohen J.E., Jayasankar V., Bish L.T., Burdick J., Pirolli T.J., Berry M.F., Hsu V., and Grand T. Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. J. Thorac. Cardiovasc. Surg. 127 (2004) 1262-1269
30. Yi J.S., Kim T.Y., Kyu Kim D., and Koh J.Y. Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia. Neurobiol. Dis. 26 (2007) 94-104
31. Ying W., Chen Y., Alano C.C., and Swanson R.A. Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes. J. Cereb. Blood Flow Metab. 22 (2002) 774-779
32. Yu Y.M., Kim J.B., Lee K.W., Kim S.Y., Han P.L., and Lee J.K. Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 36 (2005) 2238-2243
33. Zeng J., Yang G.Y., Ying W., Kelly M., Hirai K., James T.L., Swanson R.A., and Litt L. Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J. Cereb. Blood Flow Metab. 27 (2007) 304-315
34. Zheng Z., Kim J.Y., Ma H., Lee J.E., and Yenari M.A. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. J. Cereb. Blood Flow Metab. 28 (2008) 53-63