Inhibitory effects of ginsenoside Rb1, Rg3, and Panax ginseng head butanol fraction on inflammatory mediators from LPS-stimulated RAW 264.7 Cells

Biomolecules and Therapeutics

Volumn 16, Issue 3, 2008, Pages 277-285

  Lee, Je Hyuk ^a   Jeong, Choon Sik ^a  

^a Duksung Women's University   (South Korea)

Author keywords

COX 2; Ginsenoside Rb1; Ginsenoside Rg3; IL 6; iNOS; Nitric oxide; Prostaglandin E 2

Indexed keywords

BUTANOL; CYCLOOXYGENASE 2; GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RG 3; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PROSTAGLANDIN E2;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL FREE SYSTEM; CELL STIMULATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME REGULATION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; RNA TRANSCRIPTION; UPREGULATION;

ARALIACEAE; MURINAE; PANAX GINSENG;

EID: 69749110089     PISSN: 19769148     EISSN: None     Source Type: Journal    
DOI: 10.4062/biomolther.2008.16.3.277     Document Type: Article

References (26)

1. Babu, B.H., Shylesh, B.S. and Padikkala, J. (2001) Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia 72, 272-277.
2. 2 by acids and human intestinal bacteria and biological activities of their transformants. Arch. Pharm. Res. 27, 61-67.
3. Bae, E.A., Hyun, Y.J., Choo, M.K., Oh, J.K., Ryu, J.H. and Kim, D.H. (2004B) Protective effect of fermented red ginseng on a transient focal ischemic rats. Arch. Pharm. Res. 27, 1136-1140.
4. Chun, K.S., Cha, H.H., Shin, J.W., Na, H.K., Park, K.K., Chung, W.Y. and Surh, Y.J. (2004) Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kB. Carcinogenesis 25, 445-445
5. Franzotti, E.M., Santos, C.V., Rodrigues, H.M., Mourao, R.H., Andrade, M.R. and Antoniolla, A.R. (2000) Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J. Ethnopharmacol. 72, 273-277.
6. Gorgoni, B., Caivano, M., Arizmendi, C. and Poli, V. (2001) The transcription factor C/EBPβ is essential for inducible expression of the COX-2 gene in macrophages but not in fibroblasts. J. Biol. Chem. 276, 40769-40777. (Pubitemid 37373222)
7. Grimble, R.F. (1998) Nutritional modulation of cytokine biology. Nutrition 14, 634-640.
8. Honda, S., Migita, K., Hirai, Y., Ueki, Y., Yamasaki, S., Urayama, S., Kawabe, Y., Fukuda, T., Kawakami, A., Kamachi, M., Kita, M., Ida, H., Aoyagi, T. and Eguchi, K. (2000) Induction of COX-2 expression by nitric oxide in rheumatoid synovial cells. Biochem. Biophys. Res. Commun. 268, 928-931. (Pubitemid 30150893)
9. 1: the anti-ulcer constituent from the head of Panax ginseng. Arch. Pharm. Res. 26, 906-911.
10. Korhonen, R., Lahti, A., Kankaanranta, H. and Moilanen, E. (2005). Nitric oxide production and signaling in inflammation. Curr. Drug Targets Inflamm. Allergy 4, 471-479. (Pubitemid 41052412)
11. Lee, B.H., You, H.J., Park, M.S., Kwon, B. and Ji, G.E. (2006) Transformation of the ginsenosides from food materials by probiotics and food microorganisms. J. Microbiol. Biotechnol. 16, 497-504.
12. Lian, X.Y., Zhang, Z.Z. and Stringer, J.L. (2005) Anticonvulsant activity of ginseng on seizures induced by chemical convulsants. Epilepsia 46, 15-22.
13. 1, a main ingredient of ginseng root. Neurosci. Res. 28, 191-200.
14. 2 through enhancement of NF-κB activity in lipopolysaccharide-activated human primary monocytes oxidative stress augments the production of matrix. J. Immunol. 175, 5423-5429.
15. Nantel, F., Denis, D., Gordon, R., Northey, A., Cirino, M., Metters, K.M. and Chan, C.C. (1999) Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Br. J. Pharmacol. 128, 853-859. (Pubitemid 29494701)
16. Ojewole, J.A.O. (2006) Antinociceptive, anti-inflammatory and antidiabetic properties of Hypoxis hemerocallidea Fisch. & C.A. Mey.(Hypoxidaceae) corm ['African Potato'] aqueous extract in mice and rats. J. Ethnopharmacol. 103, 126-134.
17. 2 biosynthesis of RAW 264.7 cells induced by lipopolysaccharide. Biol. Pharm. Bull. 28, 652-656.
18. Perez-Sala, D. and Lamas, S. (2001) Regulation of cyclooxygenase-2 expression by nitric oxide in cells. Antioxid. Redox Signal 3, 231-248. (Pubitemid 32473339)
19. 1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res. 1021, 41-53.
20. Saito, H., Yoshida, Y. and Takagi, K. (1974) Effect of Panax Ginseng root on exhaustive exercise in mice. Jap. J. Pharmacol. 24, 119-127.
21. Salvemini, D. (1997) Regulation of cyclooxygenase enzymes by nitric oxide. Cell. Mol. Life Sci. 53, 576-582. (Pubitemid 27385181)
22. Spector, W.G. and Willoughb, D.A. (1963) The inflammatory response. Bacteriol. Rev. 27, 117-154.
23. Sutherland, H., Khundkar, R., Zolle, O., McArdle, A., Simpson, A.W., Jarvis, J.C. and Salmons, S. (2001) A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle. Nitric Oxide 5, 475-481. (Pubitemid 32953597)
24. Van Dross, R.T., Hong, X. and Pelling, J.C. (2005) Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. Mol. Carcinog. 44, 83-91. (Pubitemid 41397173)
25. Wei, T., Chen, C., Hau, J., Zhao, B., Xin, W. and Mori, A. (1999) The antioxidant EPC-k1 attenuates NO-induced mitochondrial disfunction, lipid peroxidation and apoptosis in cerebellar granuele cells. Toxicology 134, 117-126. (Pubitemid 29248885)
26. Yokota, K., Miyazaki, T., Hirano, M., Akiyama, Y. and Mimura, T. (2006). Simvastatin inhibits production of interleukin-6 (IL-6) and IL-8 and cell proliferation induced by tumor necrosis factor-α in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J. Rheumatol. 33, 463-471. (Pubitemid 43334566)