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Volumn 877, Issue 27, 2009, Pages 3159-3168
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High-throughput HPLC-MS/MS method to determine ibandronate in human plasma for pharmacokinetic applications
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Author keywords
Bisphosphonates; Derivatization; Ibandronate; Liquid chromatography; Pharmacokinetics; Plasma; Tandem mass spectrometry
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Indexed keywords
ACCURACY AND PRECISION;
ALENDRONATE;
ANALYSIS TIME;
BIOLOGICAL MATRIXES;
BISPHOSPHONATES;
DERIVATIZATION;
DERIVATIZATIONS;
DEUTERATED ANALOGUE;
HIGH-THROUGHPUT;
HPLC-MS/MS;
HUMAN PLASMAS;
IBANDRONATE;
INTERNAL STANDARDS;
ION SUPPRESSION;
LC-MS/MS;
LINEAR ION TRAP;
LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY;
LIQUID-LIQUID EXTRACTION;
PHARMACOKINETIC STUDIES;
PLASMA CONCENTRATION;
QUADRUPOLES;
REVERSED-PHASE COLUMNS;
SUPELCO;
TANDEM MASS SPECTROMETRY;
TARGET VALUES;
TRIMETHYLSILYLDIAZOMETHANE;
URINE SAMPLE;
CHROMATOGRAPHIC ANALYSIS;
CHROMATOGRAPHY;
DEUTERIUM;
DRUG PRODUCTS;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
PHARMACOKINETICS;
PLASMA (HUMAN);
PLASMAS;
SOLVENT EXTRACTION;
LIQUIDS;
IBANDRONIC ACID;
ACCURACY;
ARTICLE;
DERIVATIZATION;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HIGH THROUGHPUT SCREENING;
HUMAN;
HUMAN EXPERIMENT;
LIQUID LIQUID EXTRACTION;
PRIORITY JOURNAL;
QUALITY CONTROL;
TANDEM MASS SPECTROMETRY;
BONE DENSITY CONSERVATION AGENTS;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
DIPHOSPHONATES;
DRUG STABILITY;
HUMANS;
LINEAR MODELS;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
TANDEM MASS SPECTROMETRY;
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EID: 69749104942
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.08.007 Document Type: Article |
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Times cited : (28)
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References (19)
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