Development and application of a high-performance liquid chromatography-mass spectrometry method to determine alendronate in human urine

Journal of Chromatography A

Volumn 1160, Issue 1-2, 2007, Pages 21-33

  Tarcomnicu, Isabela ^a   Silvestro, Luigi ^b   Savu, Simona Rizea ^b   Gherase, Adriana ^a   Dulea, Constanta ^a  

^a Pharma Serv International SRL   (Romania)

^b 3S Pharmacological Consultation and Research GmbH   (Germany)

Author keywords

Alendronate; Biphosphonates; Derivatization; HPLC MS MS; Pharmacokinetics; Reversed phase; Urine

Indexed keywords

BIPHOSPHONATES; ION-PAIR CHROMATOGRAPHY; POLAR COMPOUNDS;

DRUG PRODUCTS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; SALTS; SENSITIVITY ANALYSIS;

BODY FLUIDS;

ALENDRONIC ACID; CLODRONIC ACID; ETIDRONIC ACID; PAMIDRONIC ACID;

ANALYTIC METHOD; ARTICLE; DERIVATIZATION; DRUG BIOAVAILABILITY; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION PAIR CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; URINARY EXCRETION;

ALENDRONATE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLODRONIC ACID; DIPHOSPHONATES; ETIDRONIC ACID; HUMANS; MASS SPECTROMETRY; REFERENCE STANDARDS;

EID: 34447530814     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.04.020     Document Type: Article

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